| 61941 | Robo1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity; identical protein binding (ortholog); LRR domain binding (ortholog); INVOLVED IN axon guidance; axon midline choice point recognition; cellular response to hypoxia; ASSOCIATED WITH Brain Hypoxia-Ischemia; Brain Injuries; Cancer Pain; F OUND IN axon; dendrite; neuronal cell body; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 11 | 24067869 | 25108694 | Rat | 291 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62234 | Robo1 | roundabout guidance receptor 1 | Predicted to enable LRR domain binding activity; axon guidance receptor activity; and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and regulation of gene expression. Acts upstream of or within several processes, incl uding axon guidance; heart development; and mammary duct terminal end bud growth. Located in axolemma. Is expressed in several structures, including autopod; central nervous system; genitourinary system; jaw; and sensory organ. Used to study cystic kidney disease and lung cancer. Human ortholog(s) of this gene implicated in autosomal recessive congenital nystagmus; combined or isolated pituitary hormone deficiency 8; congenital nystagmus; multiple myeloma; and plasmacytoma. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 71824406 | 72844379 | Mouse | 351 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 735617 | ROBO1 | roundabout guidance receptor 1 | Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immu noglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] | 3 | 78597239 | 79767998 | Human | 379 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8928291 | Robo1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); LRR domain binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); atria l fibrillation (ortholog); autistic disorder (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | NW_004955407 | 12593911 | 13485723 | Chinchilla | 104 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11881311 | ROBO1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); atrial fibrillation (ortholog); autistic disorder (ortholog); FOUND IN axo lemma (ortholog); axon (ortholog); dendrite (ortholog) | 3 | 78707802 | 79876519 | Bonobo | 116 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12379919 | ROBO1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); atrial fibrillation (ortholog); autistic disorder (ortholog); FOUND IN axo lemma (ortholog); axon (ortholog); dendrite (ortholog) | 31 | 8082363 | 8594623 | Dog | 120 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12668313 | Robo1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); atrial fibrillation (ortholog); autistic disorder (ortholog); FOUND IN axo lemma (ortholog); axon (ortholog); dendrite (ortholog) | NW_004936505 | 4329428 | 4711310 | Squirrel | 115 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905763 | Robo1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); LRR domain binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); atria l fibrillation (ortholog); autistic disorder (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 113 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626005585 | Robo1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); LRR domain binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); atria l fibrillation (ortholog); autistic disorder (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | | | | Black Rat | 104 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238818 | robo1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14387177 | robo1 | | | | | | Fly | | symbol | gene, null |
| 18387896 | ROBO1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); identical protein binding (ortholog); LRR domain binding (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); atria l fibrillation (ortholog); autistic disorder (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); cell surface (ortholog) | | | | Green Monkey | 106 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13905202 | ROBO1 | roundabout guidance receptor 1 | ENCODES a protein that exhibits axon guidance receptor activity (ortholog); INVOLVED IN aorta development (ortholog); aortic valve morphogenesis (ortholog); axon guidance (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); atrial fibrillation (ortholog); autistic disorder (ortholog); FOUND IN axo lemma (ortholog); axon (ortholog); dendrite (ortholog) | | | | Pig | 115 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238819 | robo1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244449 | robo1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2307439 | Robo1Tn(sb-T2/Bart3)2.327Mcwi | roundabout homolog 1 (Drosophila); transposon insertion 2.327, Medical College of Wisconsin | this mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 2nd intron of the Robo1 gene | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 16573171 | AC117461.1 | novel transcript, antisense to ROBO1 | | | | | Human | | name | gene, lncrna |
| 1348930 | SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016] | 12 | 63844700 | 64162217 | Human | 128 | description | gene, protein-coding, REVIEWED [RefSeq] |