| 1352466 | RLIM | ring finger protein, LIM domain interacting | The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcrip tion factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009] | X | 74582976 | 74614624 | Human | 182 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557038 | Rlim | ring finger protein, LIM domain interacting | Enables ubiquitin protein ligase activity. Involved in protein ubiquitination; random inactivation of X chromosome; and ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; extraembryonic component; limb; male reproductive system; and urinary system. Human ortholog(s) of this gene implicated in Tonne-Kalscheuer syndrome. Orthologous to human RLIM (ring finger protein, LIM domain interacting). [provided by Alliance of Genome Resources, Apr 2025] | X | 103000770 | 103024886 | Mouse | 133 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1559832 | Rlim | ring finger protein, LIM domain interacting | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (ortholog); pro tein ubiquitination (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); non-syndromic X-linked intellectual disability (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A | X | 73048983 | 73070302 | Rat | 114 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8849398 | Rlim | ring finger protein, LIM domain interacting | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (ortholog); pro tein ubiquitination (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); non-syndromic X-linked intellectual disability (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004955562 | 508723 | 531699 | Chinchilla | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11987600 | RLIM | ring finger protein, LIM domain interacting | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (or tholog); random inactivation of X chromosome (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); non-syndromic X-linked intellectual disability (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | X | 63834345 | 63865874 | Bonobo | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12289939 | RLIM | ring finger protein, LIM domain interacting | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (or tholog); random inactivation of X chromosome (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); non-syndromic X-linked intellectual disability (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | X | 57879749 | 57905805 | Dog | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12537865 | Rlim | ring finger protein, LIM domain interacting | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (or tholog); random inactivation of X chromosome (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); non-syndromic X-linked intellectual disability (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | NW_004936683 | 930537 | 961792 | Squirrel | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14046960 | RLIM | ring finger protein, LIM domain interacting | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (or tholog); random inactivation of X chromosome (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); non-syndromic X-linked intellectual disability (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 35 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18539159 | RLIM | ring finger protein, LIM domain interacting | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (or tholog); random inactivation of X chromosome (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); non-syndromic X-linked intellectual disability (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18900983 | Rlim | ring finger protein, LIM domain interacting | ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); obsolete negative regulation of DNA-binding transcription factor activity (ortholog); random inactivation of X chromosome (ortholog); A SSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); non-syndromic X-linked intellectual disability (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 30 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 20866727 | RLIM | ring finger protein, LIM domain interacting | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155246235 | rlim | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155244759 | rlim.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246690 | rlim.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 71074 | Lhx1 | LIM homeobox 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cellular response to fibroblast growth factor stimulus; mesonephric duct develop ment; mesonephric tubule development; ASSOCIATED WITH Female Urogenital Diseases (ortholog); genetic disease (ortholog); FOUND IN nucleus; protein-containing complex (ortholog); transcription regulator complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; all-trans-retinoic acid | 10 | 69894288 | 69901076 | Rat | 279 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 625944530 | LOC116887971 | E3 ubiquitin-protein ligase RLIM | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 14175639 | LOC100151952 | E3 ubiquitin-protein ligase RLIM-like | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); FOUND IN nucleus (inferred) | | | | Pig | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 18932787 | LOC101721381 | E3 ubiquitin-protein ligase RLIM-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 8989790 | LOC102028698 | E3 ubiquitin-protein ligase RLIM-like | | NW_004955571 | 1596804 | 1605350 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 18915521 | LOC110349932 | E3 ubiquitin-protein ligase RLIM-like | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN protein ubiquitination (inferred); random inactivation of X chromosome (inferred); ubiquitin-dependent protein catabolic process (inferred); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 18918501 | LOC110350258 | E3 ubiquitin-protein ligase RLIM-like | | | | | Naked Mole-Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 625954791 | LOC116887969 | E3 ubiquitin-protein ligase RLIM-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 625834072 | LOC116888617 | E3 ubiquitin-protein ligase RLIM-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 124907946 | LOC120885400 | E3 ubiquitin-protein ligase RLIM-like | | | | | Squirrel | | name | gene, protein-coding, MODEL [RefSeq] |
| 12107975 | LOC491808 | E3 ubiquitin-protein ligase RLIM-like | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); FOUND IN nucleus (inferred) | X | 29455208 | 29459188 | Dog | 10 | name | gene, protein-coding, MODEL [RefSeq] |
| 18906838 | LOC101705605 | E3 ubiquitin-protein ligase RLIM pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18903583 | LOC101707938 | E3 ubiquitin-protein ligase RLIM pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18921776 | LOC101709680 | E3 ubiquitin-protein ligase RLIM pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18918595 | LOC101710498 | E3 ubiquitin-protein ligase RLIM pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18906546 | LOC101717532 | E3 ubiquitin-protein ligase RLIM pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18914286 | LOC101726769 | E3 ubiquitin-protein ligase RLIM pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 8756906 | LOC102015465 | E3 ubiquitin-protein ligase RLIM pseudogene | | NW_004955443 | 15375124 | 15377155 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 9002652 | LOC102024469 | E3 ubiquitin-protein ligase RLIM pseudogene | | NW_004955420 | 13292515 | 13293631 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 18350598 | LOC103245653 | E3 ubiquitin-protein ligase RLIM pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18918142 | LOC106010663 | E3 ubiquitin-protein ligase RLIM pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1550389 | Rnf6 | ring finger protein (C3H2C3 type) 6 | Enables DNA binding activity and ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of axon extension and positive regulation of DNA-templated transcription. Located in PML body; axon; and cytoplasm. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 146146003 | 146158267 | Mouse | 140 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1563383 | Srsf19 | serine and arginine rich splicing factor 19 | ENCODES a protein that exhibits metal ion binding (inferred); nucleic acid binding (inferred); RNA binding (inferred) | X | 49612410 | 49658278 | Rat | 9 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 5129244 | RLIMP3 | ring finger protein, LIM domain interacting pseudogene 3 | | 15 | 49794045 | 49796295 | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5131589 | RLIMP1 | ring finger protein, LIM domain interacting pseudogene 1 | | 13 | 40618626 | 40621547 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 5131588 | RLIMP2 | ring finger protein, LIM domain interacting pseudogene 2 | | 1 | 113125492 | 113126955 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |