| 3256 | Reg3g | regenerating family member 3 gamma | ENCODES a protein that exhibits hormone activity (ortholog); oligosaccharide binding (ortholog); peptidoglycan binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); ASSOCIATED WITH hypertension (ortholog); FOUND IN extracellular space (ortholog); secretory granule (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 4 | 112482183 | 112484738 | Rat | 135 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1351031 | REG3G | regenerating family member 3 gamma | This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014] | 2 | 79025702 | 79028501 | Human | 108 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552800 | Reg3g | regenerating islet-derived 3 gamma | This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacteria l contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016] | 6 | 78443252 | 78445857 | Mouse | 123 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 12039834 | REG3G | regenerating family member 3 gamma | ENCODES a protein that exhibits hormone activity (ortholog); INVOLVED IN defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); MyD88-dependent toll-like receptor signaling pathway (ortholog); ASSOCIATED WITH hypertension (ortholog); FOUND IN extracellular space (ortholog); secretory granule (ortholog) | 2A | 79116083 | 79118886 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12622504 | Reg3g | regenerating family member 3 gamma | ENCODES a protein that exhibits hormone activity (ortholog); oligosaccharide binding (ortholog); peptidoglycan binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); ASSOCIATED WITH hypertension (ortholog); FOUND IN extracellular space (ortholog); secretory granule (ortholog) | NW_004936556 | 4896141 | 4898240 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14044626 | REG3G | regenerating islet-derived 3 gamma | ENCODES a protein that exhibits oligosaccharide binding (ortholog); peptidoglycan binding (ortholog); INVOLVED IN signal transduction (inferred); ASSOCIATED WITH hypertension (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 13 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18903532 | LOC101715891 | regenerating islet-derived protein 3-beta-like | ENCODES a protein that exhibits carbohydrate binding (inferred); FOUND IN extracellular region (inferred) | | | | Naked Mole-Rat | 2 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18441846 | LOC103219990 | regenerating islet-derived protein 3-gamma | ENCODES a protein that exhibits hormone activity (ortholog); oligosaccharide binding (ortholog); peptidoglycan binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); ASSOCIATED WITH hypertension (ortholog); FOUND IN extracellular space (ortholog); secretory granule (ortholog) | | | | Green Monkey | 25 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12306298 | REG3A | regenerating islet-derived 3 alpha | ENCODES a protein that exhibits oligosaccharide binding (ortholog); peptidoglycan binding (ortholog); INVOLVED IN defense response to Gram-negative bacterium (ortholog); defense response to Gram-positive bacterium (ortholog); MyD88-dependent toll-like receptor signaling pathway (ortholog); ASSOCIATE D WITH hypertension (ortholog); FOUND IN extracellular space (ortholog); secretory granule (ortholog) | 17 | 44859106 | 44864793 | Dog | 29 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1623258 | Reg3d | regenerating islet-derived 3 delta | Predicted to enable oligosaccharide binding activity; peptidoglycan binding activity; and signaling receptor activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; positive regulation of cell population proliferation; and response to peptide ho rmone. Predicted to be active in extracellular space. Orthologous to human REG3A (regenerating family member 3 alpha) and REG3G (regenerating family member 3 gamma). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 78352857 | 78355848 | Mouse | 22 | description | gene, protein-coding, VALIDATED [RefSeq] |
