Reg3g (regenerating islet-derived 3 gamma) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Reg3g (regenerating islet-derived 3 gamma) Mus musculus
Analyze
Symbol: Reg3g
Name: regenerating islet-derived 3 gamma
RGD ID: 1552800
MGI Page MGI
Description: Enables hormone activity; oligosaccharide binding activity; and peptidoglycan binding activity. Involved in several processes, including negative regulation of keratinocyte differentiation; regulation of response to wounding; and response to bacterium. Acts upstream of or within response to bacterium. Located in secretory granule. Colocalizes with extracellular space. Is expressed in several structures, including epithelium; gut; pharyngo-tympanic tube; thymus; and trachea. Orthologous to human REG3G (regenerating family member 3 gamma).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI449515; generating islet-derived, mouse homolog 3 gamma; pancreatitis-associated protein 3; reg III-gamma; REG-3-gamma; regenerating islet-derived protein 3-gamma; regenerating islet-derived protein III-gamma; RegIII (gamma)
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,443,252 - 78,445,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl678,443,252 - 78,445,855 (-)EnsemblGRCm39 Ensembl
GRCm38678,466,269 - 78,468,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,466,269 - 78,468,872 (-)EnsemblGRCm38mm10GRCm38
MGSCv37678,416,262 - 78,418,868 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36678,395,777 - 78,398,383 (-)NCBIMGSCv36mm8
Celera680,489,179 - 80,491,785 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map634.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
hypertension  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9055810   PMID:10349636   PMID:10767532   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15582152   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16931762  
PMID:17198697   PMID:17522155   PMID:17635956   PMID:17936263   PMID:18374910   PMID:19095652   PMID:19494835   PMID:20050810   PMID:21267068   PMID:21677750   PMID:21681751   PMID:21873635  
PMID:21926556   PMID:21998396   PMID:22723890   PMID:22727489   PMID:23012479   PMID:23401489   PMID:24345802   PMID:25263220   PMID:25301498   PMID:26329040   PMID:26431947   PMID:26667474  
PMID:26866937   PMID:26867181   PMID:27193261   PMID:27798352   PMID:27830702   PMID:27912059   PMID:28071719   PMID:28424327   PMID:28580440   PMID:28811323   PMID:28880262   PMID:29596938  
PMID:29850784   PMID:30089902   PMID:30106382   PMID:30831322   PMID:30973865   PMID:31132747   PMID:31404030   PMID:31817820   PMID:32560820   PMID:33027970   PMID:33876425   PMID:34195684  
PMID:34324837   PMID:35241668   PMID:35263589   PMID:36150609   PMID:36240758   PMID:36943156   PMID:37524871   PMID:38218976   PMID:38355793   PMID:38358358  


Genomics

Comparative Map Data
Reg3g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,443,252 - 78,445,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl678,443,252 - 78,445,855 (-)EnsemblGRCm39 Ensembl
GRCm38678,466,269 - 78,468,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,466,269 - 78,468,872 (-)EnsemblGRCm38mm10GRCm38
MGSCv37678,416,262 - 78,418,868 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36678,395,777 - 78,398,383 (-)NCBIMGSCv36mm8
Celera680,489,179 - 80,491,785 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map634.78NCBI
REG3G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38279,025,702 - 79,028,501 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl279,025,686 - 79,028,505 (+)EnsemblGRCh38hg38GRCh38
GRCh37279,252,828 - 79,255,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36279,106,334 - 79,109,139 (+)NCBINCBI36Build 36hg18NCBI36
Build 34279,164,480 - 79,167,283NCBI
Celera279,081,561 - 79,084,366 (+)NCBICelera
Cytogenetic Map2p12NCBI
HuRef278,988,763 - 78,991,579 (+)NCBIHuRef
CHM1_1279,182,125 - 79,184,941 (+)NCBICHM1_1
T2T-CHM13v2.0279,025,993 - 79,028,792 (+)NCBIT2T-CHM13v2.0
Reg3g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84112,482,183 - 112,484,738 (-)NCBIGRCr8
mRatBN7.24110,922,805 - 110,927,803 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4110,924,168 - 110,926,723 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4116,329,743 - 116,332,298 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04112,104,845 - 112,107,400 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04110,725,040 - 110,727,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04109,529,679 - 109,532,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4109,529,679 - 109,532,234 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04174,231,309 - 174,233,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,418,258 - 112,420,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14112,662,738 - 112,665,294 (-)NCBI
Celera499,956,121 - 99,958,676 (-)NCBICelera
Cytogenetic Map4q33NCBI
REG3G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21247,327,808 - 47,330,609 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A47,330,564 - 47,333,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A79,116,083 - 79,118,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A80,680,650 - 80,683,470 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A80,680,615 - 80,683,748 (+)Ensemblpanpan1.1panPan2
REG3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11744,859,106 - 44,864,793 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1744,859,137 - 44,861,899 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1744,496,518 - 44,499,199 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01745,677,903 - 45,680,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1745,677,825 - 45,680,586 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11744,760,939 - 44,763,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01744,797,243 - 44,799,926 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01745,296,868 - 45,299,551 (-)NCBIUU_Cfam_GSD_1.0
Reg3g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062925,830,468 - 5,841,937 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365564,896,141 - 4,898,240 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REG3G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11428,213,731 - 28,217,299 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604584,069,534 - 84,072,099 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Reg3g
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:194
Interacting mature miRNAs:204
Transcripts:ENSMUST00000032089, ENSMUST00000176650
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
13524522Bodwtq4_mbody wweight QTL 4 (mouse)67611698981876987Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse

Markers in Region
AI449515  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38678,466,783 - 78,466,863UniSTSGRCm38
MGSCv37678,416,777 - 78,416,857UniSTSGRCm37
Celera680,489,694 - 80,489,774UniSTS
Cytogenetic Map6C3UniSTS
Whitehead/MRC_RH6794.34UniSTS
D63361  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38678,466,311 - 78,466,446UniSTSGRCm38
MGSCv37678,416,305 - 78,416,440UniSTSGRCm37
Celera680,489,222 - 80,489,357UniSTS
Cytogenetic Map6C3UniSTS
Whitehead/MRC_RH6794.54UniSTS
Reg3g  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
cM Map6 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000032089   ⟹   ENSMUSP00000032089
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl678,443,252 - 78,445,855 (-)Ensembl
GRCm38.p6 Ensembl678,466,269 - 78,468,872 (-)Ensembl
Ensembl Acc Id: ENSMUST00000176650
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl678,443,252 - 78,445,554 (-)Ensembl
GRCm38.p6 Ensembl678,466,269 - 78,468,571 (-)Ensembl
RefSeq Acc Id: NM_011260   ⟹   NP_035390
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39678,443,252 - 78,445,857 (-)NCBI
GRCm38678,466,269 - 78,468,874 (-)NCBI
MGSCv37678,416,262 - 78,418,868 (-)RGD
Celera680,489,179 - 80,491,785 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035390   ⟸   NM_011260
- Peptide Label: preproprotein
- UniProtKB: O09049 (UniProtKB/Swiss-Prot),   Q545I1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000032089   ⟸   ENSMUST00000032089
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09049-F1-model_v2 AlphaFold O09049 1-174 view protein structure

Promoters
RGD ID:6890074
Promoter ID:EPDNEW_M8487
Type:initiation region
Name:Reg3g_2
Description:Mus musculus regenerating islet-derived 3 gamma , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8488  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38678,468,596 - 78,468,656EPDNEW
RGD ID:6890076
Promoter ID:EPDNEW_M8488
Type:multiple initiation site
Name:Reg3g_1
Description:Mus musculus regenerating islet-derived 3 gamma , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8487  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38678,468,869 - 78,468,929EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109406 AgrOrtholog
Ensembl Genes ENSMUSG00000030017 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032089 ENTREZGENE
  ENSMUST00000032089.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin/snaclec_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109406 ENTREZGENE
NCBI Gene 19695 ENTREZGENE
PANTHER MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGENERATING ISLET-DERIVED PROTEIN 3-GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reg3g PhenoGen
PRINTS PNCREATITSAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O09049 ENTREZGENE
  Q545I1 ENTREZGENE, UniProtKB/TrEMBL
  REG3G_MOUSE UniProtKB/Swiss-Prot