| 1353565 | PURB | purine rich element binding protein B | This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it i s implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008] | 7 | 44876299 | 44885530 | Human | 125 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1557360 | Purb | purine rich element binding protein B | Enables several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and SMAD binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts up stream of or within negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in heart and hindlimb muscle. Orthologous to human PURB (purine rich element binding protein B). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 6417599 | 6426076 | Mouse | 127 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1559465 | Purb | purine rich element binding protein B | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; mRNA regulatory element binding translation repressor activity; purine-rich negative regulatory element binding; INVOLVED IN negative regulation of transcription by RNA polymerase II; negative r egulation of DNA-templated transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleus; nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 14 | 85556296 | 85558779 | Rat | 142 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8836794 | Purb | purine rich element binding protein B | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); n egative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004955456 | 7322973 | 7323529 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11697344 | PURB | purine rich element binding protein B | ENCODES a protein that exhibits mRNA regulatory element binding translation repressor activity (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleus (ortholog) | 7 | 45590183 | 45600089 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12508528 | Purb | purine rich element binding protein B | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); n egative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004936478 | 19738252 | 19747345 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13949914 | PURB | purine rich element binding protein B | ENCODES a protein that exhibits mRNA regulatory element binding translation repressor activity (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferr ed); INTERACTS WITH deoxynivalenol | | | | Pig | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18421925 | PURB | purine rich element binding protein B | ENCODES a protein that exhibits mRNA regulatory element binding translation repressor activity (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleus (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255208 | purb | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18935548 | Purb | purine rich element binding protein B | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA po lymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12192047 | PURB | purine rich element binding protein B | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); n egative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | | | | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625881699 | Purb | purine rich element binding protein B | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); n egative regulation of transcription by RNA polymerase II (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256441 | purb.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255209 | purb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16566539 | AC004854.2 | novel transcript, antisense to PURB | | | | | Human | | name | gene, lncrna |
