| 1309842 | Psmd8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity; PARTICIPATES IN ubiquitin/proteasome degradation pathway; ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN synaptic vesicle; proteasome accessory complex (ortholog); proteasome complex (ortholog); INTERACTS WITH (+ )-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine | 1 | 93601857 | 93608689 | Rat | 119 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1320403 | PSMD8 | proteasome 26S subunit, non-ATPase 8 | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. T he 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008] | 19 | 38374571 | 38383824 | Human | 134 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553327 | Psmd8 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome accessory complex. Is expressed in brain; nose; skin; and urethra. Orthologous to human PSMD8 (proteasome 26S subunit, non-ATPase 8). [provided by A lliance of Genome Resources, Jul 2025] | 7 | 28873612 | 28880098 | Mouse | 122 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9028304 | Psmd8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN proteasome accessory complex (ortholog); proteasome complex (ortholog); synaptic vesicle (ortholog) | NW_004955468 | 1044940 | 1052130 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11963569 | PSMD8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN proteasome accessory complex (ortholog); synaptic vesicle (ortholog) | 19 | 35468519 | 35477802 | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12325904 | PSMD8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN synaptic vesicle (ortholog) | 1 | 114619478 | 114626082 | Dog | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12497455 | Psmd8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN synaptic vesicle (ortholog) | NW_004936801 | 1137480 | 1144287 | Squirrel | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13930334 | PSMD8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN synaptic vesicle (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18353457 | PSMD8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN synaptic vesicle (ortholog) | | | | Green Monkey | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934932 | Psmd8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN synaptic vesicle (ortholog) | | | | Naked Mole-Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240430 | psmd8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625930158 | Psmd8 | proteasome 26S subunit, non-ATPase 8 | INVOLVED IN regulation of AMPA receptor activity (ortholog); ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); FOUND IN proteasome accessory complex (ortholog); proteasome complex (ortholog); synaptic vesicle (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244928 | psmd8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240431 | psmd8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1594533 | Psmd8-ps1 | proteasome 26S subunit, non-ATPase 8, pseudogene 1 | | 3 | 65864664 | 65878455 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2323174 | Psmd8-ps2 | proteasome 26S subunit, non-ATPase 8, pseudogene 2 | | 15 | 90823978 | 90824759 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1553773 | Nob1 | NIN1/RPN12 binding protein 1 homolog | Predicted to enable RNA endonuclease activity. Acts upstream of or within visual perception. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of preribosome, small subunit precursor. Is expressed in nervous system and neural retina. Orthologous to human NOB1 (NIN1 (RPN12) bin ding protein 1 homolog). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 108139121 | 108151670 | Mouse | 101 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16563872 | AP000894.1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 (PSMD8) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1603053 | NOB1 | NIN1 (RPN12) binding protein 1 homolog | In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and bindin g of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010] | 16 | 69741871 | 69754926 | Human | 101 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735222 | Nob1 | NIN1 (RPN12) binding protein 1 homolog | ENCODES a protein that exhibits RNA endonuclease activity (ortholog); INVOLVED IN visual perception (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Hearing Loss, Noise-Induced; FOUND IN nucleus (inferred); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-t etrachlorodibenzodioxine | 19 | 52232543 | 52245824 | Rat | 99 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8931810 | Nob1 | NIN1 (RPN12) binding protein 1 homolog | ENCODES a protein that exhibits RNA endonuclease activity (ortholog); INVOLVED IN visual perception (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Hearing Loss, Noise-Induced (ortholog) | NW_004955484 | 6996795 | 7006499 | Chinchilla | 5 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11853836 | NOB1 | NIN1 (RPN12) binding protein 1 homolog | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN visual perception (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Hearing Loss, Noise-Induced (ortholog); FOUND IN nucleus (inferred); p reribosome, small subunit precursor (inferred) | 16 | 50122905 | 50135096 | Bonobo | 17 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12060430 | NOB1 | NIN1 (RPN12) binding protein 1 homolog | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN visual perception (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Hearing Loss, Noise-Induced (ortholog); FOUND IN nucleus (inferred) | 5 | 79958145 | 79966166 | Dog | 17 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12629260 | Nob1 | NIN1 (RPN12) binding protein 1 homolog | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN visual perception (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Hearing Loss, Noise-Induced (ortholog); FOUND IN nucleus (inferred); p reribosome, small subunit precursor (inferred) | NW_004936475 | 19794199 | 19808142 | Squirrel | 17 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14038700 | NOB1 | NIN1 (RPN12) binding protein 1 homolog | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN visual perception (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Hearing Loss, Noise-Induced (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 17 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18695467 | NOB1 | NIN1 (RPN12) binding protein 1 homolog | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN visual perception (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Hearing Loss, Noise-Induced (ortholog); FOUND IN nucleus (inferred); p reribosome, small subunit precursor (inferred) | | | | Green Monkey | 17 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18902062 | Nob1 | NIN1 (RPN12) binding protein 1 homolog | ENCODES a protein that exhibits endonuclease activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN visual perception (ortholog); PARTICIPATES IN ribosome biogenesis pathway; ASSOCIATED WITH Hearing Loss, Noise-Induced (ortholog); FOUND IN nucleus (inferred); p reribosome, small subunit precursor (inferred) | | | | Naked Mole-Rat | 17 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 5684151 | PSMD8P1 | proteasome 26S subunit, non-ATPase, 8 pseudogene 1 | | 1 | 154414272 | 154415222 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 12091622 | SPRED3 | sprouty related EVH1 domain containing 3 | INVOLVED IN negative regulation of epithelial to mesenchymal transition (ortholog); negative regulation of lens fiber cell differentiation (ortholog); negative regulation of MAPK cascade (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 1 | 114604265 | 114614764 | Dog | 11 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
