| 3370 | Ppard | peroxisome proliferator-activated receptor delta | ENCODES a protein that exhibits fatty acid binding; NF-kappaB binding; DNA binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide; decidualization; embryo implantation; PARTICIPATES IN acute myeloid leukemia pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; Wnt signaling pathway; ASSOCIATED WITH Acute-Phase Reaction; Cardiomegaly; Experimental Diabetes Mellitus; FOUND IN chromatin (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; (S)-naringenin; 17beta-estradiol | 20 | 6300527 | 6365707 | Rat | 545 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731946 | Ppard | peroxisome proliferator activator receptor delta | Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts ups tream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 28451715 | 28520446 | Mouse | 677 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736289 | PPARD | peroxisome proliferator activated receptor delta | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017] | 6 | 35342558 | 35428178 | Human | 584 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9002044 | Ppard | peroxisome proliferator activated receptor delta | ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); fatty acid binding (ortholog); linoleic acid binding (ortholog); INVOLVED IN apoptotic process (ortholog); apoptotic signaling pathway (ortholog); cellular response to lipopolysaccharide (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); alcohol-associated liver disease (ortholog); biliary tract cancer (ortholog); FOUND IN nucleus (ortholog) | NW_004955437 | 3285281 | 3354099 | Chinchilla | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11897013 | PPARD | peroxisome proliferator activated receptor delta | ENCODES a protein that exhibits fatty acid binding (ortholog); NF-kappaB binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); decidualization (ortholog); embryo implantation (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); alcohol-associated liver disease ( ortholog); biliary tract cancer (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred) | 6 | 34903798 | 34987208 | Bonobo | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12088534 | PPARD | peroxisome proliferator activated receptor delta | ENCODES a protein that exhibits fatty acid binding (ortholog); linoleic acid binding (ortholog); lipid binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); decidualization (ortholog); embryo implantation (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); alco hol-associated liver disease (ortholog); biliary tract cancer (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | 12 | 4492867 | 4579340 | Dog | 112 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12565321 | Ppard | peroxisome proliferator activated receptor delta | ENCODES a protein that exhibits fatty acid binding (ortholog); NF-kappaB binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); decidualization (ortholog); embryo implantation (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); alcohol-associated liver disease ( ortholog); biliary tract cancer (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | NW_004936476 | 23799285 | 23886606 | Squirrel | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13917753 | PPARD | peroxisome proliferator activated receptor delta | ENCODES a protein that exhibits fatty acid binding (ortholog); NF-kappaB binding (ortholog); INVOLVED IN adipose tissue development (ortholog); axon ensheathment (ortholog); cell differentiation (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); alcohol-associated liver disease (ortholog); biliary tract cancer (ortholog); FOUND IN chromatin (inferred); nucleus (inferred) | | | | Pig | 134 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18674706 | PPARD | peroxisome proliferator activated receptor delta | ENCODES a protein that exhibits fatty acid binding (ortholog); NF-kappaB binding (ortholog); INVOLVED IN adipose tissue development (ortholog); axon ensheathment (ortholog); cell differentiation (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); alcohol-associated liver disease (ortholog); biliary tract cancer (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 126 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625948663 | Ppard | peroxisome proliferator activated receptor delta | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN adipose tissue development (ortholog); apoptotic process (ortholog); apoptotic signaling path way (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); alcohol-associated liver disease (ortholog); biliary tract cancer (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog) | | | | Black Rat | 98 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902157 | Ppard | peroxisome proliferator activated receptor delta | ENCODES a protein that exhibits fatty acid binding (ortholog); linoleic acid binding (ortholog); lipid binding (ortholog); INVOLVED IN adipose tissue development (ortholog); apoptotic process (ortholog); apoptotic signaling pathway (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); alcohol -associated liver disease (ortholog); biliary tract cancer (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 123 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256864 | ppard | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155258655 | ppard.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1613169 | 1810013A23Rik | RIKEN cDNA 1810013A23 gene | | 17 | 28490682 | 28492137 | Mouse | 3 | ensembl_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |