| 1317520 | PMF1 | polyamine modulated factor 1 | Enables leucine zipper domain binding activity and transcription coactivator activity. Involved in chromosome segregation. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of MIS12/MIND type complex. Implicated in bladder carcinoma and urinary bladder cancer. [provided by Alliance of G enome Resources, Jul 2025] | 1 | 156213007 | 156240042 | Human | 98 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1317521 | Pmf1 | polyamine-modulated factor 1 | Predicted to enable leucine zipper domain binding activity and transcription coactivator activity. Predicted to be involved in chromosome segregation. Predicted to be located in Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of MIS12/MIND type complex. Is expressed in several st ructures, including central nervous system; extraembryonic component; placenta; retina; and thymus. Human ortholog(s) of this gene implicated in bladder carcinoma and urinary bladder cancer. Orthologous to several human genes including PMF1 (polyamine modulated factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 88301445 | 88317752 | Mouse | 98 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1584694 | Pmf1 | polyamine-modulated factor 1 | ENCODES a protein that exhibits leucine zipper domain binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN chromosome segregation (ortholog); ASSOCIATED WITH bladder carcinoma (ortholog); Leukoaraiosis (ortholog); urinary bladder cancer (ortholog); FOUND IN kinetochore (ort holog); MIS12/MIND type complex (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 176145896 | 176166022 | Rat | 84 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11857153 | PMF1 | polyamine modulated factor 1 | ENCODES a protein that exhibits leucine zipper domain binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN cell division (inferred); chromosome segregation (inferred); ASSOCIATED WITH bladder carcinoma (ortholog); Leukoaraiosis (ortholog); urinary bladder cancer (ortholog); FOUND IN nucleoplasm (ortholog); outer kinetochore (ortholog) | 1 | 131556843 | 131583180 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232148 | pmf1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18656968 | PMF1 | polyamine modulated factor 1 | ENCODES a protein that exhibits leucine zipper domain binding (inferred); transcription coactivator activity (inferred); INVOLVED IN cell division (inferred); chromosome segregation (inferred); positive regulation of DNA-templated transcription (inferred); ASSOCIATED WITH bladder carcinoma (ortholog ); Leukoaraiosis (ortholog); urinary bladder cancer (ortholog); FOUND IN kinetochore (inferred); MIS12/MIND type complex (inferred); nucleoplasm (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13865213 | PMF1 | polyamine modulated factor 1 | ENCODES a protein that exhibits leucine zipper domain binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN cell division (inferred); FOUND IN nucleoplasm (ortholog); outer kinetochore (ortholog) | | | | Pig | 18 | symbol , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155232147 | pmf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 5507928 | PMF1-BGLAP | PMF1-BGLAP readthrough | This locus represents naturally occurring read-through transcription between the neighboring PMF1 (polyamine-modulated factor 1) and BGLAP (bone gamma-carboxyglutamate Gla protein) genes on chromosome 1. Alternative splicing results in multiple transcript varian ts encoding isoforms that share sequence identity with the upstream gene product, but they contain distinct C-termini due to frameshifts versus the downstream gene coding sequence. [provided by RefSeq, Dec 2010] | 1 | 156212988 | 156243332 | Human | 37 | symbol , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 619567 | BGLAP | bone gamma-carboxyglutamate protein | This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalci n levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015] | 1 | 156242184 | 156243317 | Human | 522 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312617 | CENPH | centromere protein H | Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of cen tromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008] | 5 | 69189583 | 69210357 | Human | 126 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 18925243 | LOC101706757 | polyamine-modulated factor 1 | INVOLVED IN cell division (inferred); chromosome segregation (inferred); FOUND IN kinetochore (inferred); MIS12/MIND type complex (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 6 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12600544 | LOC101978306 | polyamine-modulated factor 1 | ENCODES a protein that exhibits leucine zipper domain binding (inferred); transcription coactivator activity (inferred); INVOLVED IN cell division (inferred); chromosome segregation (inferred); positive regulation of DNA-templated transcription (inferred); ASSOCIATED WITH bladder carcinoma (ortholog ); Leukoaraiosis (ortholog); urinary bladder cancer (ortholog); FOUND IN kinetochore (inferred); MIS12/MIND type complex (inferred); nucleoplasm (inferred) | NW_004936580 | 5454574 | 5479600 | Squirrel | 26 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8895009 | LOC102022746 | polyamine-modulated factor 1 | | NW_004955545 | 2365047 | 2379720 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
