| 3350 | Pld2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity; protein kinase C binding; INVOLVED IN cellular response to phorbol 13-acetate 12-myristate; neuron projection development; phospholipid catabolic process; PARTICIPATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH vascular smooth muscle hypertrophy; ASSOCIATED WITH congestive heart failure; Experimental Seizures; Myocardial Reperfusion Injury; FOUND IN caveola; lamellipodium; sarcolemma; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether | 10 | 55754957 | 55772819 | Rat | 165 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733873 | PLD2 | phospholipase D2 | The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be invol ved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] | 17 | 4807152 | 4823430 | Human | 169 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 736771 | Pld2 | phospholipase D2 | This gene is a member of the phospholipase D (PLD) superfamily. The encoded protein catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. Phosphatidic acid is an essential intracellular lipid second messenger for many signaling pathways and has been implicated in a variet y of physiological processes including cytoskeletal organization and cell proliferation. A similar gene in human may also function as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] | 11 | 70430318 | 70448936 | Mouse | 189 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8954543 | Pld2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); G protein-coupled receptor internalization (ortholog); neuron projection development (ortholog); PARTICIP ATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Seizures (ortholog); FOUND IN brush border membrane (ortholog); caveola (ortholog); lamellipodium (ortholog) | NW_004955467 | 10239177 | 10250516 | Chinchilla | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11905623 | PLD2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); G protein-coupled receptor internalization (ortholog); neuron projection development (ortholog); PARTICIP ATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Seizures (ortholog); FOUND IN caveola (ortholog); lamellipodium (ortholog); sarcolemma (ortholog) | 17 | 4853919 | 4870254 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12089434 | PLD2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); G protein-coupled receptor internalization (ortholog); neuron projection development (ortholog); PARTICIP ATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Seizures (ortholog); FOUND IN caveola (ortholog); lamellipodium (ortholog); sarcolemma (ortholog) | 5 | 31755881 | 31767131 | Dog | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12529814 | Pld2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); G protein-coupled receptor internalization (ortholog); neuron projection development (ortholog); PARTICIP ATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Seizures (ortholog); FOUND IN caveola (ortholog); lamellipodium (ortholog); sarcolemma (ortholog) | NW_004936677 | 2870664 | 2883545 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930990 | Pld2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); G protein-coupled receptor internalization (ortholog); neuron projection development (ortholog); PARTICIP ATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Seizures (ortholog); FOUND IN brush border membrane (ortholog); caveola (ortholog); lamellipodium (ortholog) | | | | Naked Mole-Rat | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14268566 | PLD2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); G protein-coupled receptor internalization (ortholog); neuron projection development (ortholog); PARTICIP ATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Seizures (ortholog); FOUND IN caveola (ortholog); lamellipodium (ortholog); sarcolemma (ortholog) | | | | Pig | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625976797 | Pld2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); G protein-coupled receptor internalization (ortholog); neuron projection development (ortholog); PARTICIP ATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Seizures (ortholog); FOUND IN brush border membrane (ortholog); caveola (ortholog); lamellipodium (ortholog) | | | | Black Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18638006 | PLD2 | phospholipase D2 | ENCODES a protein that exhibits D-type glycerophospholipase activity (ortholog); protein kinase C binding (ortholog); INVOLVED IN cellular response to phorbol 13-acetate 12-myristate (ortholog); G protein-coupled receptor internalization (ortholog); neuron projection development (ortholog); PARTICIP ATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); congestive heart failure (ortholog); Experimental Seizures (ortholog); FOUND IN caveola (ortholog); lamellipodium (ortholog); sarcolemma (ortholog) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235878 | pld2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155235879 | pld2.L | | | | | | African Clawed Frog | | symbol | gene, null |