| 1305769 | Pink1 | PTEN induced kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity; ubiquitin protein ligase binding; ATP binding (ortholog); INVOLVED IN cellular response to hydrogen sulfide; mitophagy; negative regulation of apoptotic process; PARTICIPATES IN mitochondria dynamics pathway; altered mitochond rial autophagy pathway; mitochondrial autophagy pathway; ASSOCIATED WITH abnormal gait; abnormal motor coordination/balance; abnormal muscle tone; ASSOCIATED WITH metabolic dysfunction-associated steatohepatitis; Parkinson's disease; Parkinsonism; FOUND IN endoplasmic reticulum; growth cone; mitochondrial inner membrane; INTERACTS WITH (+)-schisandrin B; 1,3-dichloropropan-2-ol; 1-naphthyl isothiocyanate | 5 | 155813838 | 155825950 | Rat | 629 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1314001 | PINK1 | PTEN induced kinase 1 | This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] | 1 | 20633458 | 20651511 | Human | 643 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1314002 | Pink1 | PTEN induced putative kinase 1 | Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and regulation of gene expression. Acts upstream of or within positive regulation of dopamine secretion ; positive regulation of dopaminergic synaptic transmission; and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Located in endoplasmic reticulum and mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Parkinson's disease 6. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 138040718 | 138053631 | Mouse | 674 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8727505 | Pink1 | PTEN induced kinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); C3HC4-type RING finger domain binding (ortholog); kinase activity (ortholog); INVOLVED IN autophagy of mitochondrion (ortholog); cellular response to hydrogen sulfide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial autophagy pathway; ASSOCIATED WITH cognitive disorder (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN astrocyte projection (ortholog); axon (ortholog); cell body (ortholog) | NW_004955452 | 1171115 | 1186338 | Chinchilla | 167 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11790485 | PINK1 | PTEN induced kinase 1 | ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to hydrogen sulfide (ortholog); hemopoiesis (ortholog); mitochondrial fission (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial a utophagy pathway; ASSOCIATED WITH cognitive disorder (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN growth cone (ortholog); mitochondrial inner membrane (ortholog); mitochondrial outer membrane (ortholog) | 1 | 19583330 | 19601248 | Bonobo | 159 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12099979 | PINK1 | PTEN induced kinase 1 | ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to hydrogen sulfide (ortholog); hemopoiesis (ortholog); mitochondrial fission (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial a utophagy pathway; ASSOCIATED WITH cognitive disorder (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN growth cone (ortholog); mitochondrial inner membrane (ortholog); mitochondrial outer membrane (ortholog) | 2 | 78276091 | 78293761 | Dog | 157 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12493389 | Pink1 | PTEN induced kinase 1 | ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to hydrogen sulfide (ortholog); hemopoiesis (ortholog); mitochondrial fission (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial a utophagy pathway; ASSOCIATED WITH cognitive disorder (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN growth cone (ortholog); mitochondrial inner membrane (ortholog); mitochondrial outer membrane (ortholog) | NW_004936474 | 6574471 | 6589478 | Squirrel | 159 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14386335 | Pink1 | | | | | | Fly | | symbol | gene, null |
| 625989370 | Pink1 | PTEN induced kinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); C3HC4-type RING finger domain binding (ortholog); kinase activity (ortholog); INVOLVED IN autophagy of mitochondrion (ortholog); cellular response to hydrogen sulfide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial autophagy pathway; ASSOCIATED WITH cognitive disorder (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN astrocyte projection (ortholog); axon (ortholog); cell body (ortholog) | | | | Black Rat | 167 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18936904 | Pink1 | PTEN induced kinase 1 | ENCODES a protein that exhibits C3HC4-type RING finger domain binding (ortholog); kinase binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN cellular response to hydrogen sulfide (ortholog); cellular response to hypoxia (ortholog); cellular response to oxidative stress (ortholog); PART ICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial autophagy pathway; ASSOCIATED WITH cognitive disorder (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN astrocyte projection (ortholog); axon (ortholog); cell body (ortholog) | | | | Naked Mole-Rat | 165 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14158689 | PINK1 | PTEN induced kinase 1 | ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to hydrogen sulfide (ortholog); hemopoiesis (ortholog); mitochondrial fission (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial a utophagy pathway; ASSOCIATED WITH cognitive disorder (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN growth cone (ortholog); mitochondrial inner membrane (ortholog); mitochondrial outer membrane (ortholog); INTERACTS WITH deoxynivalenol; fumonisin B1 | | | | Pig | 169 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18408883 | PINK1 | PTEN induced kinase 1 | ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to hydrogen sulfide (ortholog); hemopoiesis (ortholog); mitochondrial fission (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial a utophagy pathway; ASSOCIATED WITH cognitive disorder (ortholog); genetic disease (ortholog); late onset Parkinson's disease (ortholog); FOUND IN growth cone (ortholog); mitochondrial inner membrane (ortholog); mitochondrial outer membrane (ortholog) | | | | Green Monkey | 159 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 6769652 | PINK1-AS | PINK1 antisense RNA | ASSOCIATED WITH Parkinson's disease 6; INTERACTS WITH aristolochic acid A; phenylmercury acetate | 1 | 20642657 | 20652193 | Human | 3 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 7241046 | Pink1em1Sage | PTEN induced putative kinase 1; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs | ASSOCIATED WITH abnormal gait; abnormal motor coordination/balance; abnormal muscle tone; ASSOCIATED WITH Parkinson's disease | | | | Rat | 16 | symbol , old_gene_symbol | gene, allele |