| 1311355 | Phpt1 | phosphohistidine phosphatase 1 | ENCODES a protein that exhibits actin filament binding (ortholog); calcium channel inhibitor activity (ortholog); enzyme inhibitor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); lamellipodium organization (ortholog); negative regulation of T cell receptor signaling path way (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytosol (ortholog); leading edge of lamellipodium (ortholog); INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; amitrole | 3 | 28791062 | 28792905 | Rat | 98 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1322769 | PHPT1 | phosphohistidine phosphatase 1 | This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternativ e splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] | 9 | 136849409 | 136851024 | Human | 108 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1322770 | Phpt1 | phosphohistidine phosphatase 1 | Predicted to enable several functions, including calcium channel inhibitor activity; protein histidine phosphatase activity; and transmembrane transporter binding activity. Involved in positive regulation of cell motility. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human PHPT1 (phosphohistidine phosphatase 1). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 25463442 | 25465528 | Mouse | 129 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8825151 | Phpt1 | phosphohistidine phosphatase 1 | ENCODES a protein that exhibits actin filament binding (ortholog); calcium channel inhibitor activity (ortholog); enzyme inhibitor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); lamellipodium organization (ortholog); negative regulation of T cell receptor signaling path way (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytosol (ortholog); leading edge of lamellipodium (ortholog) | NW_004955513 | 4930951 | 4932509 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11821491 | PHPT1 | phosphohistidine phosphatase 1 | ENCODES a protein that exhibits actin filament binding (ortholog); calcium channel inhibitor activity (ortholog); enzyme inhibitor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); lamellipodium organization (ortholog); negative regulation of T cell receptor signaling path way (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytosol (ortholog); leading edge of lamellipodium (ortholog) | 9 | 107906160 | 107908130 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12311396 | PHPT1 | phosphohistidine phosphatase 1 | ENCODES a protein that exhibits actin filament binding (inferred); calcium channel inhibitor activity (inferred); enzyme inhibitor activity (inferred); INVOLVED IN actin cytoskeleton organization (inferred); lamellipodium organization (inferred); negative regulation of T cell receptor signaling path way (inferred); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); leading edge of lamellipodium (inferred) | 9 | 48736310 | 48737771 | Dog | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12505611 | Phpt1 | phosphohistidine phosphatase 1 | ENCODES a protein that exhibits actin filament binding (inferred); calcium channel inhibitor activity (inferred); enzyme inhibitor activity (inferred); INVOLVED IN actin cytoskeleton organization (inferred); lamellipodium organization (inferred); negative regulation of T cell receptor signaling path way (inferred); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); leading edge of lamellipodium (inferred) | NW_004936669 | 1065901 | 1067214 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18742904 | PHPT1 | phosphohistidine phosphatase 1 | ENCODES a protein that exhibits actin filament binding (inferred); calcium channel inhibitor activity (inferred); enzyme inhibitor activity (inferred); INVOLVED IN actin cytoskeleton organization (inferred); lamellipodium organization (inferred); negative regulation of T cell receptor signaling path way (inferred); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); leading edge of lamellipodium (inferred) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258806 | phpt1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626031426 | Phpt1 | phosphohistidine phosphatase 1 | ENCODES a protein that exhibits actin filament binding (ortholog); calcium channel inhibitor activity (ortholog); enzyme inhibitor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); lamellipodium organization (ortholog); negative regulation of T cell receptor signaling path way (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; FOUND IN cytosol (ortholog); leading edge of lamellipodium (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155260353 | PHPT1 | phosphohistidine phosphatase 1 | ENCODES a protein that exhibits protein histidine phosphatase activity; actin filament binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); lamellipodium organization (ortholog); negative regulation of T cell receptor signaling pa thway (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytosol; leading edge of lamellipodium (ortholog) | | | | Pig | 25 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155259796 | phpt1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 18932971 | LOC101706126 | 14 kDa phosphohistidine phosphatase | ENCODES a protein that exhibits hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); protein histidine phosphatase activity (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred) | | | | Naked Mole-Rat | 7 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13884166 | MAMDC4 | MAM domain containing 4 | ENCODES a protein that exhibits protein histidine phosphatase activity; INVOLVED IN cell-cell junction organization (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytosol | | | | Pig | 19 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |