PHPT1 (phosphohistidine phosphatase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: PHPT1 (phosphohistidine phosphatase 1) Canis lupus familiaris
Analyze
Symbol: PHPT1
Name: phosphohistidine phosphatase 1
RGD ID: 12311396
Description: ENCODES a protein that exhibits actin filament binding (inferred); calcium channel inhibitor activity (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN negative regulation of ATP citrate synthase activity (ortholog); negative regulation of lyase activity (ortholog); peptidyl-histidine dephosphorylation (ortholog); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); leading edge of lamellipodium (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 14 kDa phosphohistidine phosphatase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,736,310 - 48,737,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,736,333 - 48,737,725 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,949,921 - 47,951,381 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,614,346 - 49,615,806 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,614,371 - 49,615,763 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,390,569 - 48,392,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,689,275 - 48,690,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,736,240 - 48,737,700 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PHPT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,736,310 - 48,737,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,736,333 - 48,737,725 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,949,921 - 47,951,381 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,614,346 - 49,615,806 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,614,371 - 49,615,763 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,390,569 - 48,392,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,689,275 - 48,690,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,736,240 - 48,737,700 (-)NCBIUU_Cfam_GSD_1.0
PHPT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,849,409 - 136,851,024 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,848,724 - 136,851,027 (+)EnsemblGRCh38hg38GRCh38
GRCh379139,743,861 - 139,745,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,863,367 - 138,865,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,019,382 - 137,021,327NCBI
Celera9110,257,046 - 110,259,279 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,202,666 - 109,204,708 (+)NCBIHuRef
CHM1_19139,891,999 - 139,894,223 (+)NCBICHM1_1
T2T-CHM13v2.09149,083,591 - 149,085,206 (+)NCBIT2T-CHM13v2.0
Phpt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,463,442 - 25,465,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,463,442 - 25,465,236 (-)EnsemblGRCm39 Ensembl
GRCm38225,573,430 - 25,575,514 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,573,430 - 25,575,224 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,428,951 - 25,430,391 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,395,440 - 25,396,880 (-)NCBIMGSCv36mm8
Celera225,301,192 - 25,302,632 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.44NCBI
Phpt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,791,062 - 28,792,905 (-)NCBIGRCr8
mRatBN7.238,392,926 - 8,394,325 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx311,498,106 - 11,499,505 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,084,332 - 20,085,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,274,175 - 18,275,574 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,797,037 - 2,798,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,796,997 - 2,798,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,778,450 - 2,779,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,744,947 - 3,746,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,745,120 - 3,746,334 (-)NCBI
Celera33,217,877 - 3,219,276 (-)NCBICelera
Cytogenetic Map3p13NCBI
Phpt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,930,951 - 4,932,509 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,930,951 - 4,932,509 (+)NCBIChiLan1.0ChiLan1.0
PHPT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,551,316 - 2,553,397 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,553,651 - 2,555,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,906,160 - 107,908,130 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,877,274 - 136,878,317 (+)NCBIpanpan1.1PanPan1.1panPan2
Phpt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,307,826 - 202,309,158 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,065,900 - 1,067,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,065,901 - 1,067,214 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHPT1
(Sus scrofa - pig)		 No map positions available.
PHPT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,338,205 - 1,340,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,338,388 - 1,339,753 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,936,606 - 3,938,603 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in PHPT1
13 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000031083   ⟹   ENSCAFP00000028916
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,736,333 - 48,737,725 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845009407   ⟹   ENSCAFP00845007367
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl949,614,371 - 49,615,763 (-)Ensembl
RefSeq Acc Id: XM_005625080   ⟹   XP_005625137
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,736,310 - 48,737,771 (-)NCBI
Dog10K_Boxer_Tasha947,949,921 - 47,951,381 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022423551   ⟹   XP_022279259
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,736,310 - 48,737,689 (-)NCBI
Dog10K_Boxer_Tasha947,949,923 - 47,951,290 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038486849   ⟹   XP_038342777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1948,390,571 - 48,391,937 (-)NCBI
RefSeq Acc Id: XM_038486850   ⟹   XP_038342778
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1948,390,569 - 48,392,028 (-)NCBI
RefSeq Acc Id: XM_038548716   ⟹   XP_038404644
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0948,736,242 - 48,737,609 (-)NCBI
RefSeq Acc Id: XM_038548717   ⟹   XP_038404645
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0948,736,240 - 48,737,700 (-)NCBI
RefSeq Acc Id: XM_038612651   ⟹   XP_038468579
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0948,689,277 - 48,690,643 (-)NCBI
RefSeq Acc Id: XM_038612652   ⟹   XP_038468580
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0948,689,275 - 48,690,734 (-)NCBI
RefSeq Acc Id: XM_038677938   ⟹   XP_038533866
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,614,348 - 49,615,715 (-)NCBI
RefSeq Acc Id: XM_038677939   ⟹   XP_038533867
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0949,614,346 - 49,615,806 (-)NCBI
RefSeq Acc Id: XP_005625137   ⟸   XM_005625080
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JR32 (UniProtKB/TrEMBL),   A0A8C0SLX4 (UniProtKB/TrEMBL),   A0A8I3MSR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022279259   ⟸   XM_022423551
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSCAFP00000028916   ⟸   ENSCAFT00000031083
RefSeq Acc Id: XP_038342778   ⟸   XM_038486850
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038342777   ⟸   XM_038486849
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038468580   ⟸   XM_038612652
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038468579   ⟸   XM_038612651
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038533867   ⟸   XM_038677939
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JR32 (UniProtKB/TrEMBL),   A0A8C0SLX4 (UniProtKB/TrEMBL),   A0A8I3MSR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038533866   ⟸   XM_038677938
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038404645   ⟸   XM_038548717
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JR32 (UniProtKB/TrEMBL),   A0A8C0SLX4 (UniProtKB/TrEMBL),   A0A8I3MSR7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038404644   ⟸   XM_038548716
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCAFP00845007367   ⟸   ENSCAFT00845009407

Promoters
RGD ID:13684756
Promoter ID:EPDNEW_C2824
Type:multiple initiation site
Name:PHPT1_1
Description:phosphohistidine phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,737,739 - 48,737,799EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019551 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003960 UniProtKB/TrEMBL
  ENSCAFG00040014592 UniProtKB/TrEMBL
  ENSCAFG00845005276 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031083.5 UniProtKB/TrEMBL
  ENSCAFT00030007311.1 UniProtKB/TrEMBL
  ENSCAFT00040026881.1 UniProtKB/TrEMBL
  ENSCAFT00845009407 ENTREZGENE
  ENSCAFT00845009407.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.20.20 UniProtKB/TrEMBL
InterPro Janus UniProtKB/TrEMBL
  Janus_sf UniProtKB/TrEMBL
KEGG Report cfa:491245 UniProtKB/TrEMBL
NCBI Gene PHPT1 ENTREZGENE
PANTHER PTHR12258 UniProtKB/TrEMBL
  PTHR12258:SF10 UniProtKB/TrEMBL
Pfam Ocnus UniProtKB/TrEMBL
Superfamily-SCOP PHP14-like UniProtKB/TrEMBL
UniProt A0A8C0JR32 ENTREZGENE
  A0A8C0SLX4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MSR7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44509 ENTREZGENE