| 68329 | Pde1a | phosphodiesterase 1A | ENCODES a protein that exhibits calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process; regulation of smooth muscle cell apoptotic process; re gulation of smooth muscle cell proliferation; PARTICIPATES IN protein kinase A (PKA) signaling pathway; calcium/calcium-mediated signaling pathway; purine metabolic pathway; ASSOCIATED WITH Left Ventricular Hypertrophy; FOUND IN neuronal cell body; sperm flagellum (ortholog); INTERACTS WITH 3',5'-cyclic GMP; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil | 3 | 85152053 | 85432289 | Rat | 149 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 68458 | PDE1A | phosphodiesterase 1A | Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A >PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009] | 2 | 182140041 | 182716797 | Human | 149 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 68459 | Pde1a | phosphodiesterase 1A, calmodulin-dependent | Enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in several processes, including cAMP-mediated signaling; cGMP catabolic process; and regulation o f smooth muscle cell apoptotic process. Located in sperm flagellum. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 79664797 | 80026862 | Mouse | 167 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8991010 | Pde1a | phosphodiesterase 1A | ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog) | NW_004955403 | 14906069 | 15202710 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11926165 | PDE1A | phosphodiesterase 1A | ENCODES a protein that exhibits calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protei n kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog) | 2B | 69407511 | 69798513 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12425049 | PDE1A | phosphodiesterase 1A | ENCODES a protein that exhibits calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protei n kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog) | 36 | 25250398 | 25591775 | Dog | 25 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12652985 | Pde1a | phosphodiesterase 1A | ENCODES a protein that exhibits calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protei n kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog) | NW_004936509 | 10819067 | 11142964 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18516239 | PDE1A | phosphodiesterase 1A | ENCODES a protein that exhibits calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protei n kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922758 | Pde1a | phosphodiesterase 1A | ENCODES a protein that exhibits calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protei n kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232029 | pde1a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13937543 | PDE1A | phosphodiesterase 1A | ENCODES a protein that exhibits calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protei n kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626060828 | Pde1a | phosphodiesterase 1A | ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN cGMP catabolic process (ortholog); regulation of smooth muscle cell apoptotic process (ortholog); regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Left Ventricular Hypertrophy (ortholog); FOUND IN neuronal cell body (ortholog); sperm flagellum (ortholog) | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246379 | pde1a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258522 | pde1a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16572620 | AC012500.1 | novel transcript, antisense to PDE1A | | | | | Human | | name | gene, lncrna |