| 1305568 | Pax2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus; positive regulation of cell population proliferation; response to nut rient levels; ASSOCIATED WITH Diabetic Nephropathies; Kidney Reperfusion Injury; nephroblastoma; FOUND IN centriolar satellite (ortholog); microtubule organizing center (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bis(2-ethylhexyl) phthalate | 1 | 253555447 | 253646623 | Rat | 284 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1313673 | PAX2 | paired box 2 | PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is belie ved to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014] | 10 | 100735396 | 100829944 | Human | 436 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313674 | Pax2 | paired box 2 | Enables C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; negative regulation of apoptotic p rocess involved in development; and nervous system development. Acts upstream of or within several processes, including kidney development; mesenchymal to epithelial transition; and ureter morphogenesis. Located in nucleus. Part of protein-DNA complex. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study renal coloboma syndrome. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7; renal Wilms' tumor; and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 44735040 | 44826708 | Mouse | 473 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8836033 | Pax2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); camera-type eye development (or tholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT1 (ortholog); chronic kidney disease (ortholog); FOUND IN centriolar satellite (ortholog); microtubule organizing center (ortholog); nucleoplasm (ortholog) | NW_004955485 | 9351913 | 9430607 | Chinchilla | 145 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11809228 | PAX2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT1 (ortholog); chronic kidney disease (or tholog); FOUND IN protein-containing complex (ortholog); protein-DNA complex (ortholog) | 10 | 97344978 | 97429086 | Bonobo | 140 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12111142 | PAX2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT1 (ortholog); chronic kidney disease (or tholog); FOUND IN protein-containing complex (ortholog); protein-DNA complex (ortholog) | 28 | 13442894 | 13519853 | Dog | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12444994 | Pax2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT1 (ortholog); chronic kidney disease (or tholog); FOUND IN protein-containing complex (ortholog); protein-DNA complex (ortholog) | NW_004936600 | 4850594 | 4939010 | Squirrel | 143 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18405901 | PAX2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); camera-type eye development (or tholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT1 (ortholog); chronic kidney disease (ortholog); FOUND IN centriolar satellite (ortholog); microtubule organizing center (ortholog); nucleoplasm (ortholog) | | | | Green Monkey | 145 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236187 | pax2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14113510 | PAX2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT1 (ortholog); chronic kidney disease (or tholog); FOUND IN protein-containing complex (ortholog); protein-DNA complex (ortholog) | | | | Pig | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907533 | Pax2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); c amera-type eye development (ortholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT1 (ortholog); chronic kidney disease (ortholog); FOUND IN centriolar satellite (ortholog); microtubule organizing center (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 152 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626069779 | Pax2 | paired box 2 | ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); camera-type eye development (or tholog); ASSOCIATED WITH CAKUT (ortholog); CAKUT1 (ortholog); chronic kidney disease (ortholog); FOUND IN centriolar satellite (ortholog); microtubule organizing center (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 145 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866141 | PAX2 | paired box 2 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN animal organ development (inferred); branching involved in ureteric bud morphogenesis (inferred); DNA-templated tr anscription (inferred); FOUND IN centriolar satellite (inferred); microtubule organizing center (inferred); nucleoplasm (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding |
| 155230987 | pax2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857283 | pax2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859646 | pax2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861097 | pax2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864480 | pax2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628374673 | pax2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1316805 | Paxip1 | PAX interacting (with transcription-activation domain) protein 1 | This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regu lation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013] | 5 | 27947044 | 27999326 | Mouse | 147 | description | gene, protein-coding, VALIDATED [RefSeq] |
