Pax2 (paired box 2) - Rat Genome Database

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Gene: Pax2 (paired box 2) Ictidomys tridecemlineatus
Analyze
Symbol: Pax2
Name: paired box 2
RGD ID: 12444994
Description: ENCODES a protein that exhibits C2H2 zinc finger domain binding (ortholog); INVOLVED IN brain morphogenesis (ortholog); branching involved in ureteric bud morphogenesis (ortholog); camera-type eye development (ortholog); ASSOCIATED WITH CAKUT (ortholog); chronic kidney disease (ortholog); coloboma (ortholog); FOUND IN protein-containing complex (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: paired box protein Pax-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,215,941 - 33,325,282 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,850,552 - 4,928,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366004,850,594 - 4,939,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain morphogenesis  (ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
camera-type eye development  (ISO)
cell fate determination  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to retinoic acid  (ISO)
central nervous system development  (ISO)
cochlea development  (ISO)
cochlea morphogenesis  (ISO)
glial cell differentiation  (ISO)
inner ear morphogenesis  (ISO)
kidney development  (ISO)
mesenchymal to epithelial transition  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
mesodermal cell fate specification  (ISO)
mesonephric duct development  (ISO)
mesonephric tubule development  (ISO)
mesonephric tubule formation  (ISO)
mesonephros development  (ISO)
metanephric collecting duct development  (ISO)
metanephric distal convoluted tubule development  (ISO)
metanephric epithelium development  (IEA)
metanephric mesenchymal cell differentiation  (ISO)
metanephric mesenchyme development  (ISO)
metanephric nephron tubule formation  (ISO)
metanephros development  (ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of apoptotic process involved in metanephric collecting duct development  (ISO)
negative regulation of apoptotic process involved in metanephric nephron tubule development  (ISO)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO)
negative regulation of programmed cell death  (ISO)
negative regulation of reactive oxygen species metabolic process  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
nephric duct formation  (ISO)
neural tube closure  (ISO)
optic chiasma development  (ISO)
optic cup morphogenesis involved in camera-type eye development  (ISO)
optic nerve development  (ISO)
optic nerve morphogenesis  (ISO)
optic nerve structural organization  (ISO)
pancreas development  (ISO)
paramesonephric duct development  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
positive regulation of metanephric DCT cell differentiation  (ISO)
positive regulation of metanephric glomerulus development  (ISO)
positive regulation of optic nerve formation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
pronephric field specification  (ISO)
pronephros development  (ISO)
regulation of apoptotic process  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of metanephric nephron tubule epithelial cell differentiation  (ISO)
regulation of metanephros size  (IEA)
regulation of programmed cell death  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to nutrient levels  (ISO)
retinal pigment epithelium development  (ISO)
stem cell differentiation  (ISO)
ureter development  (ISO)
ureter maturation  (ISO)
ureter morphogenesis  (ISO)
ureteric bud development  (ISO)
urogenital system development  (ISO)
vestibulocochlear nerve formation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Pax2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,215,941 - 33,325,282 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,850,552 - 4,928,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366004,850,594 - 4,939,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,735,396 - 100,829,944 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,735,396 - 100,829,944 (+)EnsemblGRCh38hg38GRCh38
GRCh3710102,495,153 - 102,589,701 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,495,458 - 102,579,688 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410102,495,321 - 102,579,687NCBI
Celera1096,243,249 - 96,327,456 (+)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1096,133,870 - 96,218,089 (+)NCBIHuRef
CHM1_110102,789,756 - 102,873,990 (+)NCBICHM1_1
T2T-CHM13v2.010101,618,753 - 101,713,301 (+)NCBIT2T-CHM13v2.0
Pax2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,735,040 - 44,826,708 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,735,057 - 44,826,310 (+)EnsemblGRCm39 Ensembl
GRCm381944,746,601 - 44,838,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,756,045 - 44,837,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv371944,831,884 - 44,910,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,810,705 - 44,889,338 (+)NCBIMGSCv36mm8
Celera1945,528,146 - 45,605,640 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.09NCBI
Pax2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,555,447 - 253,646,623 (+)NCBIGRCr8
mRatBN7.21243,616,509 - 243,697,454 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,616,606 - 243,695,321 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,764,024 - 251,843,009 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,462,042 - 258,540,874 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01251,113,975 - 251,192,959 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,493,579 - 264,585,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,936,269 - 272,027,514 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,804,055 - 249,895,306 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11250,026,899 - 250,155,758 (+)NCBI
Celera1239,428,164 - 239,506,765 (+)NCBICelera
Cytogenetic Map1q54NCBI
Pax2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554859,350,087 - 9,430,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554859,351,913 - 9,430,607 (-)NCBIChiLan1.0ChiLan1.0
PAX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,618,587 - 112,713,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,623,907 - 112,718,321 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01097,344,978 - 97,429,086 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,822,676 - 100,904,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,822,676 - 100,904,028 (+)Ensemblpanpan1.1panPan2
PAX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,442,894 - 13,519,853 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,442,893 - 13,532,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,606,001 - 13,692,205 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,904,432 - 13,990,703 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,900,260 - 13,992,558 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12813,450,612 - 13,536,833 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,492,258 - 13,578,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,623,521 - 13,709,771 (+)NCBIUU_Cfam_GSD_1.0
PAX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,823,308 - 111,913,969 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,822,334 - 111,914,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214121,481,577 - 121,574,679 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216393
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,763,975 - 93,847,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604854,813,496 - 54,880,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pax2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624831375,866 - 453,930 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624831375,851 - 453,968 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005333677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040272486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000011574   ⟹   ENSSTOP00000010388
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366004,850,759 - 4,928,148 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000031072   ⟹   ENSSTOP00000026265
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366004,850,552 - 4,928,214 (-)Ensembl
RefSeq Acc Id: XM_005333677   ⟹   XP_005333734
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,325,280 (-)NCBI
SpeTri2.0NW_0049366004,850,594 - 4,939,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040272471   ⟹   XP_040128405
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,322,866 (-)NCBI
RefSeq Acc Id: XM_040272472   ⟹   XP_040128406
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,325,043 (-)NCBI
RefSeq Acc Id: XM_040272473   ⟹   XP_040128407
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,322,866 (-)NCBI
RefSeq Acc Id: XM_040272474   ⟹   XP_040128408
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,325,043 (-)NCBI
RefSeq Acc Id: XM_040272475   ⟹   XP_040128409
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,325,043 (-)NCBI
RefSeq Acc Id: XM_040272476   ⟹   XP_040128410
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,322,864 (-)NCBI
RefSeq Acc Id: XM_040272477   ⟹   XP_040128411
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,215,941 - 33,322,875 (-)NCBI
RefSeq Acc Id: XM_040272478   ⟹   XP_040128412
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,325,042 (-)NCBI
RefSeq Acc Id: XM_040272479   ⟹   XP_040128413
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,325,042 (-)NCBI
RefSeq Acc Id: XM_040272480   ⟹   XP_040128414
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,322,869 (-)NCBI
RefSeq Acc Id: XM_040272481   ⟹   XP_040128415
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,322,864 (-)NCBI
RefSeq Acc Id: XM_040272482   ⟹   XP_040128416
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,322,870 (-)NCBI
RefSeq Acc Id: XM_040272483   ⟹   XP_040128417
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,325,282 (-)NCBI
RefSeq Acc Id: XM_040272484   ⟹   XP_040128418
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,325,280 (-)NCBI
RefSeq Acc Id: XM_040272485   ⟹   XP_040128419
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,247,324 - 33,323,173 (-)NCBI
RefSeq Acc Id: XM_040272486   ⟹   XP_040128420
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721333,248,068 - 33,325,044 (-)NCBI
RefSeq Acc Id: XP_005333734   ⟸   XM_005333677
- Peptide Label: isoform X14
- UniProtKB: A0A287CY56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040128411   ⟸   XM_040272477
- Peptide Label: isoform X7
RefSeq Acc Id: XP_040128417   ⟸   XM_040272483
- Peptide Label: isoform X13
RefSeq Acc Id: XP_040128418   ⟸   XM_040272484
- Peptide Label: isoform X15
RefSeq Acc Id: XP_040128406   ⟸   XM_040272472
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040128409   ⟸   XM_040272475
- Peptide Label: isoform X5
RefSeq Acc Id: XP_040128408   ⟸   XM_040272474
- Peptide Label: isoform X4
- UniProtKB: I3MHL2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040128413   ⟸   XM_040272479
- Peptide Label: isoform X9
RefSeq Acc Id: XP_040128412   ⟸   XM_040272478
- Peptide Label: isoform X8
RefSeq Acc Id: XP_040128419   ⟸   XM_040272485
- Peptide Label: isoform X16
RefSeq Acc Id: XP_040128416   ⟸   XM_040272482
- Peptide Label: isoform X12
RefSeq Acc Id: XP_040128414   ⟸   XM_040272480
- Peptide Label: isoform X10
RefSeq Acc Id: XP_040128405   ⟸   XM_040272471
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040128407   ⟸   XM_040272473
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040128410   ⟸   XM_040272476
- Peptide Label: isoform X6
RefSeq Acc Id: XP_040128415   ⟸   XM_040272481
- Peptide Label: isoform X11
RefSeq Acc Id: XP_040128420   ⟸   XM_040272486
- Peptide Label: isoform X17
Ensembl Acc Id: ENSSTOP00000026265   ⟸   ENSSTOT00000031072
Ensembl Acc Id: ENSSTOP00000010388   ⟸   ENSSTOT00000011574
Protein Domains
Paired


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000011575 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011574.3 UniProtKB/TrEMBL
  ENSSTOT00000031072.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  PAIRED_DNA-bd_dom UniProtKB/TrEMBL
  Paired_dom UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
  PAX_fam UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Pax2 ENTREZGENE
PANTHER PAIRED BOX PROTEIN PAX-2 UniProtKB/TrEMBL
  PTHR45636 UniProtKB/TrEMBL
Pfam PAX UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
PRINTS PAIREDBOX UniProtKB/TrEMBL
PROSITE PAIRED_1 UniProtKB/TrEMBL
  PAIRED_2 UniProtKB/TrEMBL
SMART PAX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A287CY56 ENTREZGENE, UniProtKB/TrEMBL
  I3MHL2 ENTREZGENE, UniProtKB/TrEMBL