| 1310568 | Parp2 | poly (ADP-ribose) polymerase 2 | ENCODES a protein that exhibits chromatin binding (ortholog); damaged DNA binding (ortholog); NAD DNA ADP-ribosyltransferase activity (ortholog); INVOLVED IN hippocampal neuron apoptotic process; positive regulation of cell growth involved in cardiac muscle cell development; response to oxygen-gluco se deprivation; PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; base excision repair pathway; ASSOCIATED WITH Cardiomegaly; lipodystrophy (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 2,4-dinitrotoluene; bisphenol A | 15 | 26494722 | 26517893 | Rat | 145 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1553525 | Parp2 | poly (ADP-ribose) polymerase family, member 2 | Enables NAD+ poly-ADP-ribosyltransferase activity. Involved in decidualization. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 51045347 | 51058758 | Mouse | 208 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602134 | PARP2 | poly(ADP-ribose) polymerase 2 | This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding doma in which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008] | 14 | 20343635 | 20357904 | Human | 163 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9000347 | Parp2 | poly(ADP-ribose) polymerase 2 | ENCODES a protein that exhibits chromatin binding (ortholog); damaged DNA binding (ortholog); NAD DNA ADP-ribosyltransferase activity (ortholog); INVOLVED IN base-excision repair (ortholog); decidualization (ortholog); DNA ADP-ribosylation (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono a nd poly-ribosylation; ASSOCIATED WITH Cardiomegaly (ortholog); lipodystrophy (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955550 | 1138976 | 1152293 | Chinchilla | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11897239 | PARP2 | poly(ADP-ribose) polymerase 2 | ENCODES a protein that exhibits catalytic activity (inferred); chromatin binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); extrinsic apoptotic signaling pathway (ortholog); hippocampal neuron apoptotic process (ortholog); PARTICIPATES IN ADP-ribosylatio n pathway, mono and poly-ribosylation; ASSOCIATED WITH Cardiomegaly (ortholog); lipodystrophy (ortholog); FOUND IN site of DNA damage (ortholog) | 14 | 1215727 | 1230006 | Bonobo | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12069184 | PARP2 | poly(ADP-ribose) polymerase 2 | ENCODES a protein that exhibits catalytic activity (inferred); chromatin binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); extrinsic apoptotic signaling pathway (ortholog); hippocampal neuron apoptotic process (ortholog); PARTICIPATES IN ADP-ribosylatio n pathway, mono and poly-ribosylation; ASSOCIATED WITH Cardiomegaly (ortholog); lipodystrophy (ortholog); FOUND IN site of DNA damage (ortholog); INTERACTS WITH bisphenol A | 15 | 17705966 | 17716743 | Dog | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12548053 | Parp2 | poly(ADP-ribose) polymerase 2 | ENCODES a protein that exhibits catalytic activity (inferred); chromatin binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); extrinsic apoptotic signaling pathway (ortholog); hippocampal neuron apoptotic process (ortholog); PARTICIPATES IN ADP-ribosylatio n pathway, mono and poly-ribosylation; ASSOCIATED WITH Cardiomegaly (ortholog); lipodystrophy (ortholog); FOUND IN site of DNA damage (ortholog) | NW_004936877 | 554969 | 564905 | Squirrel | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240437 | parp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626038679 | Parp2 | poly(ADP-ribose) polymerase 2 | ENCODES a protein that exhibits chromatin binding (ortholog); damaged DNA binding (ortholog); NAD DNA ADP-ribosyltransferase activity (ortholog); INVOLVED IN base-excision repair (ortholog); decidualization (ortholog); DNA ADP-ribosylation (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono a nd poly-ribosylation; ASSOCIATED WITH Cardiomegaly (ortholog); lipodystrophy (ortholog); FOUND IN nucleolus (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18611358 | PARP2 | poly(ADP-ribose) polymerase 2 | ENCODES a protein that exhibits catalytic activity (inferred); chromatin binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); extrinsic apoptotic signaling pathway (ortholog); hippocampal neuron apoptotic process (ortholog); PARTICIPATES IN ADP-ribosylatio n pathway, mono and poly-ribosylation; ASSOCIATED WITH Cardiomegaly (ortholog); lipodystrophy (ortholog); FOUND IN site of DNA damage (ortholog) | | | | Green Monkey | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930142 | Parp2 | poly(ADP-ribose) polymerase 2 | ENCODES a protein that exhibits chromatin binding (ortholog); damaged DNA binding (ortholog); NAD DNA ADP-ribosyltransferase activity (ortholog); INVOLVED IN base-excision repair (ortholog); decidualization (ortholog); DNA ADP-ribosylation (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono a nd poly-ribosylation; ASSOCIATED WITH Cardiomegaly (ortholog); lipodystrophy (ortholog); FOUND IN site of DNA damage (ortholog) | | | | Naked Mole-Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14249503 | PARP2 | poly(ADP-ribose) polymerase 2 | ENCODES a protein that exhibits catalytic activity (inferred); chromatin binding (inferred); damaged DNA binding (inferred); INVOLVED IN base-excision repair (ortholog); extrinsic apoptotic signaling pathway (ortholog); hippocampal neuron apoptotic process (ortholog); PARTICIPATES IN ADP-ribosylatio n pathway, mono and poly-ribosylation; ASSOCIATED WITH Cardiomegaly (ortholog); lipodystrophy (ortholog); FOUND IN site of DNA damage (ortholog) | | | | Pig | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234122 | parp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246011 | parp2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1619921 | Rpph1 | ribonuclease P RNA component H1 | Orthologous to human RPPH1 (ribonuclease P RNA component H1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 51044904 | 51045228 | Mouse | 44 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |