| 619928 | Pabpn1 | poly(A) binding protein, nuclear 1 | ENCODES a protein that exhibits RNA polymerase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); MAPK cascade (ortholog); poly(A)+ mRNA export from nucleus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; influenza A pathway; mRNA decay pathway; ASSOC IATED WITH oculopharyngeal muscular dystrophy (ortholog); FOUND IN nuclear inclusion body; nuclear speck (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 15 | 32337955 | 32342700 | Rat | 129 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1345820 | PABPN1 | poly(A) binding protein nuclear 1 | This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-st ate, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010] | 14 | 23321457 | 23326163 | Human | 169 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550881 | Pabpn1 | poly(A) binding protein, nuclear 1 | Enables RNA polymerase binding activity. Involved in MAPK cascade; cellular response to lipopolysaccharide; and positive regulation of polynucleotide adenylyltransferase activity. Located in nucleus. Part of ribonucleoprotein complex. Is expressed in central nervous system; sensory organ; and thymus . Used to study oculopharyngeal muscular dystrophy. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 55131600 | 55136384 | Mouse | 139 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8888339 | Pabpn1 | poly(A) binding protein nuclear 1 | ENCODES a protein that exhibits RNA polymerase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); MAPK cascade (ortholog); poly(A)+ mRNA export from nucleus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ASSOCIATED WITH oculopharyngeal muscular dystr ophy (ortholog); FOUND IN nuclear inclusion body (ortholog); nuclear speck (ortholog); nucleoplasm (ortholog) | NW_004955409 | 37000423 | 37004823 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12024471 | PABPN1 | poly(A) binding protein nuclear 1 | ENCODES a protein that exhibits RNA polymerase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); MAPK cascade (ortholog); poly(A)+ mRNA export from nucleus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ASSOCIATED WITH oculopharyngeal muscular dystr ophy (ortholog); FOUND IN nuclear inclusion body (ortholog); nuclear speck (ortholog); nucleoplasm (ortholog) | 14 | 4126179 | 4144810 | Bonobo | 39 | symbol , ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12275832 | PABPN1 | poly(A) binding protein nuclear 1 | ENCODES a protein that exhibits RNA polymerase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); MAPK cascade (ortholog); poly(A)+ mRNA export from nucleus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ASSOCIATED WITH oculopharyngeal muscular dystr ophy (ortholog); FOUND IN nuclear inclusion body (ortholog); nuclear speck (ortholog); nucleoplasm (ortholog) | 8 | 3580768 | 3585546 | Dog | 32 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14235115 | PABPN1 | poly(A) binding protein nuclear 1 | ENCODES a protein that exhibits RNA polymerase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); MAPK cascade (ortholog); positive regulation of polynucleotide adenylyltransferase activity (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ASSOCIATED WI TH oculopharyngeal muscular dystrophy (ortholog); FOUND IN nuclear inclusion body (ortholog) | | | | Pig | 34 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155234537 | pabpn1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626162150 | Pabpn1 | poly(A) binding protein nuclear 1 | ENCODES a protein that exhibits RNA polymerase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); MAPK cascade (ortholog); poly(A)+ mRNA export from nucleus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ASSOCIATED WITH oculopharyngeal muscular dystr ophy (ortholog); FOUND IN nuclear inclusion body (ortholog); nuclear speck (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256029 | pabpn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234536 | pabpn1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 5507955 | BCL2L2-PABPN1 | BCL2L2-PABPN1 readthrough | This locus represents naturally occurring read-through transcription between the neighboring BCL2L2 (BCL2-like 2) and PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14. The read-through transcript encodes a fusion protein that shares sequence id entity with each individual gene product. [provided by RefSeq, Dec 2010] | 14 | 23306833 | 23326163 | Human | 14 | symbol , COSMIC , name , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 18929456 | LOC101714601 | polyadenylate-binding protein 2 | ENCODES a protein that exhibits nucleic acid binding (inferred); poly(A) binding (inferred); RNA binding (inferred); INVOLVED IN mRNA processing (inferred); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 9 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12502281 | LOC101973872 | bcl-2-like protein 2 | ENCODES a protein that exhibits RNA polymerase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); MAPK cascade (ortholog); poly(A)+ mRNA export from nucleus (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ASSOCIATED WITH oculopharyngeal muscular dystr ophy (ortholog); FOUND IN nuclear inclusion body (ortholog); nuclear speck (ortholog); nucleoplasm (ortholog) | NW_004936722 | 1039970 | 1044942 | Squirrel | 47 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18617007 | LOC103231469 | bcl-2-like protein 2 | ENCODES a protein that exhibits RNA polymerase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); MAPK cascade (ortholog); positive regulation of polynucleotide adenylyltransferase activity (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ASSOCIATED WI TH oculopharyngeal muscular dystrophy (ortholog); FOUND IN nuclear inclusion body (ortholog) | | | | Green Monkey | 46 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1562761 | Pabpn1l | PABPN1 like | ENCODES a protein that exhibits poly(A) binding (ortholog); RNA binding (ortholog); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic proce ss (ortholog); PARTICIPATES IN influenza A pathway; mRNA decay pathway; FOUND IN cytoplasm (ortholog); INTERACTS WITH acrylamide; bisphenol A; C60 fullerene | 19 | 67578494 | 67581938 | Rat | 37 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 16551952 | PABPN1P1 | PABPN1 pseudogene 1 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 27096012 | PABPN1P1 | PABPN1 pseudogene 1 | | X | 71419229 | 71420649 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16560903 | PABPN1P2 | PABPN1 pseudogene 2 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 27095974 | PABPN1P2 | PABPN1 pseudogene 2 | | 19 | 52810143 | 52814026 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 3078328 | PABPN1L | PABPN1 like, cytoplasmic | Predicted to enable poly(A) binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to act upstream of or within maternal-to-zygotic transition of gene expression; negative regulation of SCF-dependent proteasomal ubiquitin-de pendent catabolic process; and negative regulation of protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 88863333 | 88870135 | Human | 33 | symbol , COSMIC , name , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 9017082 | Pabpn1l | PABPN1 like, cytoplasmic | ENCODES a protein that exhibits poly(A) binding (ortholog); RNA binding (ortholog); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic proce ss (ortholog); FOUND IN cytoplasm (ortholog) | NW_004955541 | 2718076 | 2720322 | Chinchilla | 9 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11928431 | PABPN1L | PABPN1 like, cytoplasmic | ENCODES a protein that exhibits nucleic acid binding (inferred); poly(A) binding (inferred); RNA binding (inferred); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ub iquitin-dependent catabolic process (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | 16 | 69579421 | 69583803 | Bonobo | 16 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12065828 | PABPN1L | PABPN1 like, cytoplasmic | ENCODES a protein that exhibits poly(A) binding (ortholog); RNA binding (ortholog); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic proce ss (ortholog); FOUND IN cytoplasm (ortholog) | 5 | 64525929 | 64527654 | Dog | 9 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12485019 | Pabpn1l | PABPN1 like, cytoplasmic | ENCODES a protein that exhibits nucleic acid binding (inferred); poly(A) binding (inferred); RNA binding (inferred); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ub iquitin-dependent catabolic process (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | NW_004936641 | 880548 | 883098 | Squirrel | 16 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 13860636 | PABPN1L | PABPN1 like, cytoplasmic | ENCODES a protein that exhibits nucleic acid binding (inferred); poly(A) binding (inferred); RNA binding (inferred); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ub iquitin-dependent catabolic process (ortholog); FOUND IN cytoplasm (inferred) | | | | Pig | 16 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18466669 | PABPN1L | PABPN1 like, cytoplasmic | ENCODES a protein that exhibits nucleic acid binding (inferred); poly(A) binding (inferred); RNA binding (inferred); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ub iquitin-dependent catabolic process (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 16 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18922266 | Pabpn1l | PABPN1 like, cytoplasmic | ENCODES a protein that exhibits nucleic acid binding (inferred); poly(A) binding (inferred); RNA binding (inferred); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ub iquitin-dependent catabolic process (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 626023069 | Pabpn1l | PABPN1 like, cytoplasmic | ENCODES a protein that exhibits poly(A) binding (ortholog); RNA binding (ortholog); INVOLVED IN maternal-to-zygotic transition of gene expression (ortholog); negative regulation of protein ubiquitination (ortholog); negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic proce ss (ortholog); FOUND IN cytoplasm (ortholog) | | | | Black Rat | 9 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 16555702 | AL049564.1 | poly(A) binding protein, nuclear 1 (PABPN1) pseudogene | | X | 67533154 | 67533943 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 1557279 | Pabpn1l | poly(A)binding protein nuclear 1-like | Enables poly(A) binding activity. Acts upstream of or within regulation of macromolecule metabolic process. Located in cytoplasm. Is expressed in 1-cell stage embryo; gonad; retina; and thymus. Orthologous to human PABPN1L (PABPN1 /span> like, cytoplasmic). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 123346210 | 123349474 | Mouse | 42 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155236667 | pabpn1l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155238384 | pabpn1l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236668 | pabpn1l.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1551699 | Bcl2l2 | BCL2-like 2 | Predicted to enable channel activity; identical protein binding activity; and protein domain specific binding activity. Acts upstream of or within Sertoli cell proliferation and extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and mitochondrial membrane. Is expressed in several structures, including brain; early conceptus; eye; female reproductive system; and intestine. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 55120900 | 55125691 | Mouse | 236 | ensembl_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12058309 | BCL2L2 | BCL2 like 2 | ENCODES a protein that exhibits BH domain binding (ortholog); disordered domain specific binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to amyloid-beta (ortholog); cellular response to estradiol stimulus (o rtholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); atrophy of testis (ortholog); azoospermia (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); cytosol (ortholog); mitochondrial membrane (ortholog); INTERACTS WITH bisphenol A | 8 | 3569335 | 3573922 | Dog | 82 | ensembl_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14173088 | BCL2L2 | BCL2 like 2 | ENCODES a protein that exhibits BH domain binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to amyloid-beta (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN intrinsic ap optotic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); atrophy of testis (ortholog); azoospermia (ortholog); FOUND IN cytosol (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog) | | | | Pig | 82 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1352362 | BCL2L2 | BCL2 like 2 | This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gen e in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010] | 14 | 23306833 | 23311751 | Human | 202 | description | gene, protein-coding, REVIEWED [RefSeq] |