Pabpn1l (poly(A)binding protein nuclear 1-like) - Rat Genome Database

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Pathways
Gene: Pabpn1l (poly(A)binding protein nuclear 1-like) Mus musculus
Analyze
Symbol: Pabpn1l
Name: poly(A)binding protein nuclear 1-like
RGD ID: 1557279
MGI Page MGI
Description: Enables poly(A) binding activity. Acts upstream of or within negative regulation of protein metabolic process and regulation of gene expression. Located in cytoplasm. Is expressed in 1-cell stage embryo; gonad; retina; and thymus. Orthologous to human PABPN1L (PABPN1 like, cytoplasmic).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: embryonic poly(A) binding protein 2; embryonic poly(A)-binding protein 2; embryonic poly(A)-binding protein type II; embryonic polyadenylate-binding protein 2; ePA; ePABP-2; ePABP2; Gm1108; Pabpnl1; poly(A)-binding protein nuclear-like 1; poly(A)binding protein nuclear-like 1; T-cell receptor alpha chain V region (8/10-2)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,346,210 - 123,349,474 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,346,210 - 123,349,478 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388122,619,471 - 122,622,735 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,619,471 - 122,622,739 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv378125,143,371 - 125,146,635 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368125,505,561 - 125,508,825 (-)NCBIMGSCv36mm8
Celera8126,848,856 - 126,852,111 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.93NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA,ISA,ISS)
cytosol  (TAS)

Molecular Function
nucleic acid binding  (IEA)
poly(A) binding  (IBA,IDA,ISA,ISS)
RNA binding  (IDA,IEA,IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10725249   PMID:10922068   PMID:11544199   PMID:12477932   PMID:15083517   PMID:15630085   PMID:21677750   PMID:21873635   PMID:23341629   PMID:30973865   PMID:32558204   PMID:34726234  
PMID:36306357   PMID:37889087   PMID:38057116   PMID:38355793  


Genomics

Comparative Map Data
Pabpn1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,346,210 - 123,349,474 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,346,210 - 123,349,478 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388122,619,471 - 122,622,735 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,619,471 - 122,622,739 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv378125,143,371 - 125,146,635 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368125,505,561 - 125,508,825 (-)NCBIMGSCv36mm8
Celera8126,848,856 - 126,852,111 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.93NCBI
PABPN1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,863,333 - 88,870,135 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,863,333 - 88,866,660 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371688,929,741 - 88,933,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,455,535 - 87,460,515 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1673,996,625 - 74,001,605 (-)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1674,626,902 - 74,630,229 (-)NCBIHuRef
CHM1_11690,341,014 - 90,344,336 (-)NCBICHM1_1
T2T-CHM13v2.01694,933,691 - 94,940,493 (-)NCBIT2T-CHM13v2.0
Pabpn1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,578,494 - 67,581,938 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1967,578,496 - 67,581,895 (-)EnsemblGRCr8
mRatBN7.21950,669,965 - 50,673,409 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,669,967 - 50,673,366 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1957,464,760 - 57,468,206 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,144,881 - 58,148,325 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,363,378 - 60,366,824 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1961,376,697 - 61,380,159 (-)NCBI
Lyon_Normotensive1959,499,435 - 59,502,879 (-)NCBI
Lyon_Hypertensive1961,372,896 - 61,376,340 (-)NCBI
F344_StmMcwi1959,107,523 - 59,110,969 (-)NCBI
Rnor_6.01955,430,808 - 55,434,252 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,430,810 - 55,434,252 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01966,139,323 - 66,142,767 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41952,898,178 - 52,901,622 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1949,909,361 - 49,912,805 (-)NCBICelera
Cytogenetic Map19q12NCBI
Pabpn1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,718,076 - 2,720,322 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049555412,718,076 - 2,720,322 (-)NCBIChiLan1.0ChiLan1.0
PABPN1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21898,638,053 - 98,643,564 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,550,599 - 104,555,722 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,579,421 - 69,583,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,234,156 - 89,237,595 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,234,156 - 89,237,595 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
PABPN1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,525,929 - 64,527,654 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha564,537,238 - 64,539,350 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0564,745,924 - 64,748,036 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1564,772,060 - 64,774,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,603,706 - 64,605,818 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,009,793 - 65,011,905 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pabpn1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11559,996,957 - 59,999,840 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440934925,126,917 - 25,129,241 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641880,548 - 883,098 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936641880,548 - 883,098 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PABPN1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6858,888 - 861,604 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.16854,605 - 861,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.261,049,074 - 1,054,344 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PABPN1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1585,507,295 - 85,511,078 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660471,374,462 - 1,377,258 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1574,251,084 - 74,256,543 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,252,703 - 74,255,857 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Pabpn1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624746776,692 - 779,187 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_004624746776,677 - 779,555 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Pabpn1l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11742,247,583 - 42,250,811 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Pabpn1l
170 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:183
Interacting mature miRNAs:200
Transcripts:ENSMUST00000093059
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8111481497130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8110415083130127694Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120726739130027694Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8111481497130127694Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8110415083130127694Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined114439420126055880Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse

Markers in Region
Pabpnl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388122,619,738 - 122,620,911UniSTSGRCm38
MGSCv378125,143,638 - 125,144,811UniSTSGRCm37
Celera8126,849,115 - 126,850,287UniSTS
Cytogenetic Map8E1UniSTS
cM Map8 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000093059   ⟹   ENSMUSP00000090747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8123,346,210 - 123,349,478 (-)Ensembl
GRCm38.p6 Ensembl8122,619,471 - 122,622,739 (-)Ensembl
Ensembl Acc Id: ENSMUST00000212966   ⟹   ENSMUSP00000148736
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8123,346,210 - 123,349,478 (-)Ensembl
GRCm38.p6 Ensembl8122,619,546 - 122,622,734 (-)Ensembl
RefSeq Acc Id: NM_001007462   ⟹   NP_001007463
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398123,346,210 - 123,349,474 (-)NCBI
GRCm388122,619,471 - 122,622,735 (-)ENTREZGENE
MGSCv378125,143,371 - 125,146,635 (-)RGD
Celera8126,848,856 - 126,852,111 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001007463 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI41317 (Get FASTA)   NCBI Sequence Viewer  
  AAI41318 (Get FASTA)   NCBI Sequence Viewer  
  AAI45635 (Get FASTA)   NCBI Sequence Viewer  
  DAA02003 (Get FASTA)   NCBI Sequence Viewer  
  EDL11696 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000090747
  ENSMUSP00000090747.3
GenBank Protein Q5XFR0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007463   ⟸   NM_001007462
- UniProtKB: B9EJ43 (UniProtKB/Swiss-Prot),   Q5XFR0 (UniProtKB/Swiss-Prot),   B7ZP52 (UniProtKB/TrEMBL),   A0A1D5RMD9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000090747   ⟸   ENSMUST00000093059
Ensembl Acc Id: ENSMUSP00000148736   ⟸   ENSMUST00000212966
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XFR0-F1-model_v2 AlphaFold Q5XFR0 1-273 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685954 AgrOrtholog
Ensembl Genes ENSMUSG00000069867 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000093059 ENTREZGENE
  ENSMUST00000093059.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report mmu:382035 UniProtKB/Swiss-Prot
MGD MGI:2685954 ENTREZGENE
NCBI Gene 382035 ENTREZGENE
PANTHER EMBRYONIC POLYADENYLATE-BINDING PROTEIN 2 UniProtKB/Swiss-Prot
  EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Pabpn1l PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A1D5RMD9 ENTREZGENE, UniProtKB/TrEMBL
  B7ZP52 ENTREZGENE, UniProtKB/TrEMBL
  B9EJ43 ENTREZGENE
  EPAB2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B9EJ43 UniProtKB/Swiss-Prot