| 3243 | P2rx6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity; protein-containing complex binding; INVOLVED IN cell surface receptor signaling pathway (inferred); cell-cell signaling (inferred); excitatory postsynaptic potential (inferred); PARTICIPATES IN calcium/calc ium-mediated signaling pathway; FOUND IN dendritic spine; endoplasmic reticulum membrane; glutamatergic synapse; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; alpha-Zearalanol | 11 | 96944167 | 96956424 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11045 | P2rx6 | purinergic receptor P2X, ligand-gated ion channel, 6 | Predicted to enable extracellularly ATP-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transmembrane transport. Located in neuronal cell body and nucleus. Is expressed in central nervous system; heart; parathyroid gland; reproductive system; and respiratory system. Orthologous to human P2RX6 (purinergic receptor P2X 6). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 17379749 | 17389879 | Mouse | 105 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736820 | P2RX6 | purinergic receptor P2X 6 | The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009] | 22 | 21009799 | 21028008 | Human | 106 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9031928 | P2rx6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity (ortholog); protein-containing complex binding (ortholog); FOUND IN cell junction (ortholog); cytoplasm (ortholog); dendritic spine (ortholog) | NW_004955442 | 19263544 | 19272231 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11871441 | P2RX6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN calcium ion transmembrane transport (inferred); excitatory postsynaptic potential (inferred); monoatomic cation transmembrane transport (inferred); FOUND IN dendritic spine (ortholog); endoplasmic reticulum membrane (ortholog); glutamatergic synapse (ortholog) | 22 | 3239019 | 3251966 | Bonobo | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12306655 | P2RX6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN excitatory postsynaptic potential (inferred); monoatomic cation transmembrane transport (inferred); monoatomic ion transmembrane transpo rt (inferred); FOUND IN dendritic spine (ortholog); endoplasmic reticulum membrane (ortholog); glutamatergic synapse (ortholog) | 26 | 30456231 | 30467674 | Dog | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12536701 | P2rx6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN calcium ion transmembrane transport (inferred); cell surface receptor signaling pathway (inferred); cell-cell signaling (inferred); FOUN D IN dendritic spine (ortholog); endoplasmic reticulum membrane (ortholog); glutamatergic synapse (ortholog) | NW_004936619 | 2560685 | 2567612 | Squirrel | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18438059 | P2RX6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN calcium ion transmembrane transport (inferred); excitatory postsynaptic potential (inferred); monoatomic cation transmembrane transport (inferred); FOUND IN dendritic spine (ortholog); endoplasmic reticulum membrane (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18936087 | P2rx6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN calcium ion transmembrane transport (inferred); cell surface receptor signaling pathway (inferred); cell-cell signaling (inferred); FOUN D IN cytoplasm (ortholog); dendritic spine (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286558178 | p2rx6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13852486 | P2RX6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN excitatory postsynaptic potential (inferred); monoatomic cation transmembrane transport (inferred); monoatomic ion transmembrane transpo rt (inferred); FOUND IN dendritic spine (ortholog); endoplasmic reticulum membrane (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625916488 | P2rx6 | purinergic receptor P2X 6 | ENCODES a protein that exhibits extracellularly ATP-gated monoatomic cation channel activity (ortholog); protein-containing complex binding (ortholog); FOUND IN cell junction (ortholog); cytoplasm (ortholog); dendritic spine (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626185454 | p2rx6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177726 | p2rx6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 2303847 | P2RX6P | purinergic receptor P2X 6 pseudogene | INTERACTS WITH benzene-1,2,4-triol; benzo[a]pyrene; lipopolysaccharide | 22 | 21042392 | 21044249 | Human | 5 | symbol , COSMIC , Human Proteome Map | gene, pseudo, PROVISIONAL [RefSeq] |