| 2811 | Onecut1 | one cut homeobox 1 | ENCODES a protein that exhibits DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; INVOLVED IN glucose metabolic process; positive regulation of transcription by RNA polymerase II; anatomical s tructure morphogenesis (ortholog); PARTICIPATES IN maturity-onset diabetes of the young pathway; ASSOCIATED WITH polycystic liver disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 84480066 | 84507848 | Rat | 166 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10721 | Onecut1 | one cut domain, family member 1 | Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; negative regulation of transforming growth facto r beta receptor signaling pathway; and spleen development. Located in nucleus. Is expressed in several structures, including central nervous system; gut; liver and biliary system; retina; and urinary system. Orthologous to human ONECUT1 (one cut homeobox 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 74769203 | 74796930 | Mouse | 218 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732947 | ONECUT1 | one cut homeobox 1 | This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of c ellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] | 15 | 52755053 | 52790336 | Human | 162 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8733132 | Onecut1 | one cut homeobox 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); B cell differentiation (ortholog); cell differentiation (ortholog); AS SOCIATED WITH polycystic liver disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | NW_004955409 | 2181364 | 2214636 | Chinchilla | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11888671 | ONECUT1 | one cut homeobox 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); B cell differentia tion (ortholog); cell differentiation (ortholog); ASSOCIATED WITH polycystic liver disease (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 15 | 31694830 | 31727644 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12217419 | ONECUT1 | one cut homeobox 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); B cell differentia tion (ortholog); cell differentiation (ortholog); ASSOCIATED WITH polycystic liver disease (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 30 | 18384533 | 18425940 | Dog | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626105756 | Onecut1 | one cut homeobox 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); B cell differentiation (ortholog); cell differentiation (ortholog); AS SOCIATED WITH polycystic liver disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231115 | onecut1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 125045786 | Onecut1 | one cut homeobox 1 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH polycystic liver disease (ortho log); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Squirrel | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18899816 | Onecut1 | one cut homeobox 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); B cell differentiation (ortholog); cell differentiation (ortholog); AS SOCIATED WITH polycystic liver disease (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13873558 | ONECUT1 | one cut homeobox 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); B cell differentia tion (ortholog); cell differentiation (ortholog); ASSOCIATED WITH polycystic liver disease (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18713500 | ONECUT1 | one cut homeobox 1 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); B cell differentiation (ortholog); cell differentiation (ortholog); AS SOCIATED WITH polycystic liver disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866770 | ONECUT1 | one cut homeobox 1 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); regulation of transcription by RNA polymerase II (inferred); FOUND IN nucleoplasm (inferred); nucleus (infer red) | | | | Green Monkey | 18 | symbol | gene, protein-coding |
| 155251066 | onecut1.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155239629 | onecut1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858581 | onecut1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626185680 | onecut1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862993 | onecut1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858607 | onecut1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865486 | onecut1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468399 | onecut1.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252395 | onecut1.2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12715566 | LOC101960907 | uncharacterized LOC101960907 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN anatomical structure morphogenesis (ortholog); B cell differentiation (ortholog); cell differentiation (ortholog); FO UND IN nucleus (ortholog) | NW_004936471 | 14532888 | 14581258 | Squirrel | 30 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |