| 1307879 | Nus1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (ortholog); prenyltransferase activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl diphosphate biosynthetic process (ortholog); dolichyl monophosp hate biosynthetic process (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant intellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (ortholog); endoplasmic reticulum membrane (ortholog); membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A | 20 | 32354519 | 32381265 | Rat | 135 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1317328 | NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit | This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly e xpressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017] | 6 | 117675469 | 117710727 | Human | 238 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317329 | Nus1 | NUS1 dehydrodolichyl diphosphate synthase subunit | Enables prenyltransferase activity. Acts upstream of or within cholesterol homeostasis; protein mannosylation; and regulation of intracellular cholesterol transport. Located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congen ital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 52293643 | 52316288 | Mouse | 179 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8842706 | Nus1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (ortholog); prenyltransferase activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl diphosphate biosynthetic process (ortholog); dolichyl monophosp hate biosynthetic process (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant intellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (ortholog); endoplasmic reticulum membrane (ortholog); membrane (ortholog) | NW_004955436 | 825387 | 850558 | Chinchilla | 37 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11939607 | NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits prenyltransferase activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl diphosphate biosynthetic process (ortholog); dolichyl monophosphate biosynthetic process (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant in tellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | 6 | 115486422 | 115521317 | Bonobo | 46 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12136022 | NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (inferred); prenyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl monophosphate biosynthetic pro cess (ortholog); positive regulation of cell migration involved in sprouting angiogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant intellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | 1 | 57866760 | 57895505 | Dog | 52 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12654039 | Nus1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (inferred); prenyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl monophosphate biosynthetic pro cess (ortholog); positive regulation of cell migration involved in sprouting angiogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant intellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | NW_004936658 | 695431 | 718891 | Squirrel | 45 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14169919 | NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (inferred); prenyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl monophosphate biosynthetic pro cess (ortholog); positive regulation of cell migration involved in sprouting angiogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant intellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 53 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14378803 | NUS1 | | | | | | Yeast | | symbol | gene, null |
| 18577620 | NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (inferred); prenyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl monophosphate biosynthetic pro cess (ortholog); positive regulation of cell migration involved in sprouting angiogenesis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant intellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | | | | Green Monkey | 51 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18905456 | Nus1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits prenyltransferase activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl diphosphate biosynthetic process (ortholog); dolichyl monophosphate biosynthetic process (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant in tellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | | | | Naked Mole-Rat | 46 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155246745 | nus1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625901129 | Nus1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ENCODES a protein that exhibits ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (ortholog); prenyltransferase activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); dolichyl diphosphate biosynthetic process (ortholog); dolichyl monophosp hate biosynthetic process (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant intellectual developmental disorder 55 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN dehydrodolichyl diphosphate synthase complex (ortholog); endoplasmic reticulum membrane (ortholog); membrane (ortholog) | | | | Black Rat | 36 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155232515 | nus1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247830 | nus1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 41332271 | Nus1-ps1 | NUS1 dehydrodolichyl diphosphate synthase subunit, pseudogene 1 | | 17 | 2480256 | 2481279 | Rat | | symbol , old_gene_name , PhenoGen , name | gene, pseudo, MODEL [RefSeq] |
| 3466382 | NUS1P3 | NUS1 pseudogene 3 | INTERACTS WITH antimycin A; deguelin; ethyl methanesulfonate | 13 | 24327708 | 24332108 | Human | 5 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 3340337 | NUS1P1 | NUS1 pseudogene 1 | INTERACTS WITH lead diacetate; tunicamycin | X | 47509795 | 47513660 | Human | 3 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 3077881 | NUS1P2 | NUS1 pseudogene 2 | | 13 | 22915461 | 22917546 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 3102882 | NUS1P4 | NUS1 pseudogene 4 | | 13 | 98610106 | 98610874 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11704470 | LOC100976335 | dehydrodolichyl diphosphate synthase complex subunit NUS1-like | | 13 | 79782531 | 79802336 | Bonobo | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 11969637 | LOC100981419 | dehydrodolichyl diphosphate synthase complex subunit NUS1-like | | 13 | 4220923 | 4225223 | Bonobo | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 11733799 | LOC100987076 | dehydrodolichyl diphosphate synthase complex subunit NUS1-like | | 13 | 5647136 | 5648890 | Bonobo | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18910160 | LOC101704825 | dehydrodolichyl diphosphate synthase complex subunit NUS1-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18904874 | LOC101708458 | dehydrodolichyl diphosphate synthase complex subunit NUS1-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 12496236 | LOC101970288 | dehydrodolichyl diphosphate synthase complex subunit NUS1-like | | NW_004936687 | 2074137 | 2076150 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 626011881 | LOC116907128 | dehydrodolichyl diphosphate synthase complex subunit Nus1-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 329331580 | LOC129394211 | dehydrodolichyl diphosphate synthase complex subunit NUS1-like | ENCODES a protein that exhibits ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity (inferred); prenyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN angiogenesis (inferred); cell differentiation (inferred); dolichyl monophos phate biosynthetic process (inferred); FOUND IN dehydrodolichyl diphosphate synthase complex (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred) | 16 | 24960843 | 24963458 | Bonobo | 15 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18936350 | LOC101719633 | dehydrodolichyl diphosphate synthase complex subunit NUS1 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18561514 | LOC103214880 | dehydrodolichyl diphosphate synthase complex subunit NUS1 pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 18914751 | LOC106009388 | dehydrodolichyl diphosphate synthase complex subunit NUS1 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |