Nus1 (NUS1 dehydrodolichyl diphosphate synthase subunit) - Rat Genome Database

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Gene: Nus1 (NUS1 dehydrodolichyl diphosphate synthase subunit) Mus musculus
Analyze
Symbol: Nus1
Name: NUS1 dehydrodolichyl diphosphate synthase subunit
RGD ID: 1317329
MGI Page MGI
Description: Enables prenyltransferase activity. Acts upstream of or within cholesterol homeostasis; protein mannosylation; and regulation of intracellular cholesterol transport. Located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1600027K07Rik; AU019165; AW538011; BC003223; D10Ertd438; D10Ertd438e; dehydrodolichyl diphosphate syntase complex subunit Nus1; dehydrodolichyl diphosphate synthase complex subunit Nus1; di-trans,poly-cis-decaprenylcistransferase; MGC7199; Ng; ngBR; nogo-B receptor; nuclear undecaprenyl pyrophosphate synthase 1 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm19198  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391052,293,643 - 52,316,288 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1052,293,643 - 52,316,279 (+)EnsemblGRCm39 Ensembl
GRCm381052,417,547 - 52,440,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1052,417,547 - 52,440,183 (+)EnsemblGRCm38mm10GRCm38
MGSCv371052,137,353 - 52,159,998 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361052,106,015 - 52,125,181 (+)NCBIMGSCv36mm8
Celera1053,256,151 - 53,278,472 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1026.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16835300   PMID:17585875   PMID:19723497   PMID:21873635   PMID:25066056   PMID:26746789   PMID:26755743   PMID:27480224   PMID:28068323  
PMID:29217477   PMID:32325033   PMID:33812996   PMID:35316220   PMID:36996002  


Genomics

Comparative Map Data
Nus1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391052,293,643 - 52,316,288 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1052,293,643 - 52,316,279 (+)EnsemblGRCm39 Ensembl
GRCm381052,417,547 - 52,440,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1052,417,547 - 52,440,183 (+)EnsemblGRCm38mm10GRCm38
MGSCv371052,137,353 - 52,159,998 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361052,106,015 - 52,125,181 (+)NCBIMGSCv36mm8
Celera1053,256,151 - 53,278,472 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1026.64NCBI
NUS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386117,675,469 - 117,710,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6117,675,469 - 117,710,727 (+)EnsemblGRCh38hg38GRCh38
GRCh376117,996,632 - 118,031,890 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,103,310 - 118,138,583 (+)NCBINCBI36Build 36hg18NCBI36
Build 346118,103,362 - 118,136,441NCBI
Celera6118,739,521 - 118,774,823 (+)NCBICelera
Cytogenetic Map6q22.1NCBI
HuRef6115,577,729 - 115,612,992 (+)NCBIHuRef
CHM1_16118,260,511 - 118,295,775 (+)NCBICHM1_1
T2T-CHM13v2.06118,859,707 - 118,894,963 (+)NCBIT2T-CHM13v2.0
Nus1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82032,354,519 - 32,381,265 (+)NCBIGRCr8
mRatBN7.22031,811,817 - 31,838,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2031,811,817 - 31,838,561 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2032,816,930 - 32,844,014 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02032,207,839 - 32,234,926 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02032,937,789 - 32,964,535 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02033,557,052 - 33,584,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2033,557,052 - 33,584,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02035,336,831 - 35,363,790 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42031,143,886 - 31,170,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12031,144,058 - 31,181,953 (+)NCBI
Celera2033,209,636 - 33,236,417 (+)NCBICelera
Cytogenetic Map20q11NCBI
Nus1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955436825,387 - 850,558 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955436825,387 - 850,558 (+)NCBIChiLan1.0ChiLan1.0
NUS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25137,691,995 - 137,726,079 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16135,585,206 - 135,619,090 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06115,486,422 - 115,521,317 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16119,626,895 - 119,661,552 (+)NCBIpanpan1.1PanPan1.1panPan2
NUS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,866,760 - 57,895,505 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl157,866,879 - 57,893,077 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha158,669,766 - 58,698,455 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,050,809 - 58,079,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,050,871 - 58,079,506 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,952,148 - 57,980,842 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0157,793,092 - 57,821,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,424,589 - 58,453,383 (+)NCBIUU_Cfam_GSD_1.0
Nus1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946108,588,710 - 108,612,028 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936658695,609 - 718,746 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936658695,431 - 718,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,156,778 - 44,186,194 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,156,771 - 44,186,224 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,503,144 - 49,532,778 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11356,115,581 - 56,147,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1356,113,428 - 56,147,982 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604028,444,435 - 28,478,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nus1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479812,130,569 - 12,154,314 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479812,132,570 - 12,154,252 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nus1
891 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:846
Count of miRNA genes:526
Interacting mature miRNAs:624
Transcripts:ENSMUST00000023830, ENSMUST00000161678
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103097449964974630Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103157713665577284Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
21079434Bdym5_mbody mass QTL 5 (mouse)104054599654836096Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104557609669135830Mouse
14697707Stsl2_mSalmonella typhimurium susceptibility locus 2 (mouse)104627609653876096Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104627609669235830Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104797449970112651Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse

Markers in Region
RH136533  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381052,437,720 - 52,437,905UniSTSGRCm38
MGSCv371052,157,526 - 52,157,711UniSTSGRCm37
Celera1053,276,000 - 53,276,185UniSTS
Cytogenetic Map10B3UniSTS
cM Map1029.0UniSTS
AW538011  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381052,438,595 - 52,438,712UniSTSGRCm38
MGSCv371052,158,401 - 52,158,518UniSTSGRCm37
Celera1053,276,875 - 53,276,992UniSTS
Cytogenetic Map10B3UniSTS
cM Map1029.0UniSTS
D10Ertd438e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381052,437,652 - 52,437,852UniSTSGRCm38
MGSCv371052,157,458 - 52,157,658UniSTSGRCm37
Celera1053,275,932 - 53,276,132UniSTS
Cytogenetic Map10B3UniSTS
cM Map1029.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023830   ⟹   ENSMUSP00000023830
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1052,293,643 - 52,316,279 (+)Ensembl
GRCm38.p6 Ensembl1052,417,547 - 52,440,183 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218983
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1052,305,027 - 52,309,468 (+)Ensembl
GRCm38.p6 Ensembl1052,428,931 - 52,433,372 (+)Ensembl
RefSeq Acc Id: NM_030250   ⟹   NP_084526
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391052,293,643 - 52,316,288 (+)NCBI
GRCm381052,417,547 - 52,440,192 (+)ENTREZGENE
MGSCv371052,137,353 - 52,159,998 (+)RGD
Celera1053,256,152 - 53,278,472 (+)ENTREZGENE
cM Map10 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_084526   ⟸   NM_030250
- UniProtKB: Q3TIR7 (UniProtKB/Swiss-Prot),   Q3TIA3 (UniProtKB/Swiss-Prot),   Q0P6D7 (UniProtKB/Swiss-Prot),   Q3U1Z4 (UniProtKB/Swiss-Prot),   Q99LJ8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000023830   ⟸   ENSMUST00000023830

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99LJ8-F1-model_v2 AlphaFold Q99LJ8 1-297 view protein structure

Promoters
RGD ID:6819686
Promoter ID:MM_KWN:4127
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_030250
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361052,136,971 - 52,137,967 (+)MPROMDB
RGD ID:8671968
Promoter ID:EPDNEW_M14015
Type:initiation region
Name:Nus1_1
Description:Mus musculus NUS1 dehydrodolichyl diphosphate synthase subunit, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381052,417,559 - 52,417,619EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1196365 AgrOrtholog
Ensembl Genes ENSMUSG00000023068 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023830 ENTREZGENE
  ENSMUST00000023830.16 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1180.10 UniProtKB/Swiss-Prot
InterPro Nus1/NgBR UniProtKB/Swiss-Prot
  UPP_synth-like UniProtKB/Swiss-Prot
  UPP_synth-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:52014 UniProtKB/Swiss-Prot
MGD MGI:1196365 ENTREZGENE
NCBI Gene 52014 ENTREZGENE
PANTHER DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 UniProtKB/Swiss-Prot
  PTHR21528 UniProtKB/Swiss-Prot
Pfam Prenyltransf UniProtKB/Swiss-Prot
PhenoGen Nus1 PhenoGen
Superfamily-SCOP SSF64005 UniProtKB/Swiss-Prot
UniProt NGBR_MOUSE UniProtKB/Swiss-Prot
  Q0P6D7 ENTREZGENE
  Q3TIA3 ENTREZGENE
  Q3TIR7 ENTREZGENE
  Q3U1Z4 ENTREZGENE
  Q99LJ8 ENTREZGENE
UniProt Secondary Q0P6D7 UniProtKB/Swiss-Prot
  Q3TIA3 UniProtKB/Swiss-Prot
  Q3TIR7 UniProtKB/Swiss-Prot
  Q3U1Z4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Nus1  NUS1 dehydrodolichyl diphosphate synthase subunit    nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED