| 1359489 | Nub1 | negative regulator of ubiquitin-like proteins 1 | INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); proteasomal protein catabolic process (ortholog); protein ubiquitination (ortholog); PARTICIPATES IN neddylation pathway; FOUND IN Lewy body (ortholog); nucleolus (ortholog); nucleoplasm (ortholo g); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol | 4 | 11335376 | 11366263 | Rat | 80 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1552732 | Nub1 | negative regulator of ubiquitin-like proteins 1 | Acts upstream of or within proteasomal protein catabolic process. Located in Lewy body and nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 24890813 | 24915376 | Mouse | 113 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602112 | NUB1 | negative regulator of ubiquitin like proteins 1 | This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] | 7 | 151341812 | 151378449 | Human | 78 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8928607 | Nub1 | negative regulator of ubiquitin like proteins 1 | INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); proteasomal protein catabolic process (ortholog); protein ubiquitination (ortholog); FOUND IN Lewy body (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | NW_004955491 | 5709791 | 5737620 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11920244 | NUB1 | negative regulator of ubiquitin like proteins 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); FOUND IN Lewy body (inferred); nucleolus (inferred); nucleoplasm (inferred) | 7 | 142927730 | 142964475 | Bonobo | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12079754 | NUB1 | negative regulator of ubiquitin like proteins 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); FOUND IN Lewy body (inferred); nucleolus (inferred); nucleoplasm (inferred) | 16 | 15355237 | 15382284 | Dog | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12701026 | Nub1 | negative regulator of ubiquitin like proteins 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); FOUND IN Lewy body (inferred); nucleolus (inferred); nucleoplasm (inferred) | NW_004936527 | 6726363 | 6756445 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625891335 | Nub1 | negative regulator of ubiquitin like proteins 1 | INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); proteasomal protein catabolic process (ortholog); protein ubiquitination (ortholog); FOUND IN Lewy body (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14097016 | NUB1 | negative regulator of ubiquitin like proteins 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); FOUND IN Lewy body (inferred); nucleolus (inferred); nucleoplasm (inferred) | | | | Pig | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285138665 | nub1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18758599 | NUB1 | negative regulator of ubiquitin like proteins 1 | INVOLVED IN proteasomal protein catabolic process (ortholog); FOUND IN Lewy body (inferred); nucleolus (inferred); nucleoplasm (inferred) | | | | Green Monkey | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926364 | Nub1 | negative regulator of ubiquitin like proteins 1 | INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); proteasomal protein catabolic process (ortholog); protein ubiquitination (ortholog); FOUND IN Lewy body (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285138731 | nub1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1558531 | Npm3 | nucleoplasmin 3 | Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Acts upstream of or within rRNA processing and rRNA transcription. Located in nucleolus. Is expressed in several structures, including alimentary system; endocrine gland; male reproductive gland or or gan; ovary follicle; and respiratory system. Orthologous to human NPM3 (nucleophosmin/nucleoplasmin 3). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 45736173 | 45738004 | Mouse | 108 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
