| 619952 | Nsfl1c | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding; phospholipid binding; ubiquitin binding; INVOLVED IN Golgi organization; membrane fusion; establishment of mitotic spindle orientation (ortholog); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; FOUND IN cytosol; spindle pole cent rosome; VCP-NSFL1C complex; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,5-hexanedione | 3 | 160438708 | 160463261 | Rat | 143 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734170 | NSFL1C | NSFL1 cofactor | N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p 97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011] | 20 | 1442166 | 1466849 | Human | 137 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553394 | Nsfl1c | NSFL1 (p97) cofactor (p47) | Predicted to enable ATPase binding activity and ubiquitin binding activity. Predicted to contribute to phospholipid binding activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Part of VCP-NSFL1C complex. Is expressed in central nervous system and retina. Orthologous to human NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 151336102 | 151353230 | Mouse | 141 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8809209 | Nsfl1c | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding (ortholog); phospholipid binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN establishment of mitotic spindle orientation (ortholog); Golgi organization (ortholog); membrane fusion (ortholog); FOUND IN cytosol (ortholog); spindle pole centroso me (ortholog); VCP-NSFL1C complex (ortholog) | NW_004955596 | 648978 | 673586 | Chinchilla | 27 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 11925268 | NSFL1C | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding (ortholog); phospholipid binding (ortholog); INVOLVED IN Golgi organization (ortholog); membrane fusion (ortholog); FOUND IN spindle pole centrosome (ortholog) | 20 | 1597171 | 1622708 | Bonobo | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12301870 | NSFL1C | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding (ortholog); phospholipid binding (ortholog); INVOLVED IN Golgi organization (ortholog); membrane fusion (ortholog); FOUND IN cytosol (ortholog); spindle pole centrosome (ortholog) | 24 | 19575543 | 19599002 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12522016 | Nsfl1c | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding (ortholog); phospholipid binding (ortholog); INVOLVED IN Golgi organization (ortholog); membrane fusion (ortholog); FOUND IN spindle pole centrosome (ortholog) | NW_004936485 | 17217462 | 17238253 | Squirrel | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626172196 | nsfl1c | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626029329 | Nsfl1c | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding (ortholog); phospholipid binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN establishment of mitotic spindle orientation (ortholog); Golgi organization (ortholog); membrane fusion (ortholog); FOUND IN cytosol (ortholog); spindle pole centroso me (ortholog); VCP-NSFL1C complex (ortholog) | | | | Black Rat | 27 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 18439285 | NSFL1C | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding (ortholog); phospholipid binding (ortholog); INVOLVED IN Golgi organization (ortholog); membrane fusion (ortholog); FOUND IN spindle pole centrosome (ortholog) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902414 | Nsfl1c | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding (ortholog); phospholipid binding (ortholog); INVOLVED IN establishment of mitotic spindle orientation (ortholog); Golgi organization (ortholog); membrane fusion (ortholog); FOUND IN spindle pole centrosome (ortholog) | | | | Naked Mole-Rat | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626181908 | nsfl1c | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626181280 | nsfl1c | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14183252 | NSFL1C | NSFL1 cofactor | ENCODES a protein that exhibits ATPase binding (ortholog); phospholipid binding (ortholog); INVOLVED IN Golgi organization (ortholog); membrane fusion (ortholog); FOUND IN cytosol (ortholog); spindle pole centrosome (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 36 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1589709 | Nsfl1c-ps1 | NSFL1 cofactor, pseudogene 1 | | 17 | 61752195 | 61753386 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16559694 | AC024451.2 | NSFL1 (p97) cofactor (p47) (NSFL1C) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 731622 | Vcp | valosin containing protein | Enables several functions, including ATP hydrolysis activity; K48-linked polyubiquitin modification-dependent protein binding activity; and adenyl ribonucleotide binding activity. Involved in ATP metabolic process; positive regulation of mitochondrial membrane potential; and proteasomal protein cata bolic process. Acts upstream of or within aggresome assembly and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane. Part of several cellular components, including VCP-NSFL1C complex; cytoplasmic ubiquitin ligase complex; and endoplasmic reticulum membrane. Is active in synapse. Is expressed in several structures, including cerebral cortex; early embryo; gonad; gut; and triceps surae muscle. Used to study frontotemporal dementia and inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 42979964 | 43000507 | Mouse | 495 | description | gene, protein-coding, VALIDATED [RefSeq] |