| 3199 | Npy5r | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity; pancreatic polypeptide receptor activity; peptide YY receptor activity; INVOLVED IN eating behavior; generation of ovulation cycle rhythm; negative regulation of acute inflammatory response to antigenic stimulus; ASSOCIATED WITH absen ce epilepsy; alcohol use disorder; coronary restenosis; FOUND IN 9+0 non-motile cilium (ortholog); GABA-ergic synapse (ortholog); membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitriptyline | 16 | 27822055 | 27830012 | Rat | 113 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11017 | Npy5r | neuropeptide Y receptor Y5 | Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in synaptic signaling via neuropeptide. Acts upstream of or within chemical synaptic transmission. Located in membrane and neuron projection. Is active in GABA-ergic synapse and presynapse. Is expressed in ce ntral nervous system and retina. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 67132617 | 67140746 | Mouse | 162 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 731586 | NPY5R | neuropeptide Y receptor Y5 | The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cel ls from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015] | 4 | 163343892 | 163352403 | Human | 117 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8950879 | Npy5r | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity (ortholog); pancreatic polypeptide receptor activity (ortholog); peptide YY receptor activity (ortholog); INVOLVED IN cardiac left ventricle morphogenesis (ortholog); chemical synaptic transmission (ortholog); eating behavior (ortholog ); ASSOCIATED WITH absence epilepsy (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN 9+0 non-motile cilium (ortholog); GABA-ergic synapse (ortholog); membrane (ortholog) | NW_004955403 | 41667632 | 41675619 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11817874 | NPY5R | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity (ortholog); pancreatic polypeptide receptor activity (ortholog); peptide YY receptor activity (ortholog); INVOLVED IN cardiac left ventricle morphogenesis (ortholog); chemical synaptic transmission (ortholog); eating behavior (ortholog ); ASSOCIATED WITH absence epilepsy (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN 9+0 non-motile cilium (ortholog); GABA-ergic synapse (ortholog); membrane (ortholog) | 4 | 155603739 | 155612302 | Bonobo | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12083720 | NPY5R | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity (ortholog); pancreatic polypeptide receptor activity (ortholog); peptide YY receptor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); eating behavior (ortholog); generation of ovulation cycle rhythm (ortholog ); ASSOCIATED WITH absence epilepsy (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN 9+0 non-motile cilium (inferred); GABA-ergic synapse (inferred); membrane (inferred) | 15 | 59600212 | 59608576 | Dog | 60 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12578558 | Npy5r | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity (ortholog); pancreatic polypeptide receptor activity (ortholog); peptide YY receptor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); eating behavior (ortholog); generation of ovulation cycle rhythm (ortholog ); ASSOCIATED WITH absence epilepsy (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN 9+0 non-motile cilium (inferred); GABA-ergic synapse (inferred); membrane (inferred) | NW_004936555 | 2248699 | 2252637 | Squirrel | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18359231 | NPY5R | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity (ortholog); pancreatic polypeptide receptor activity (ortholog); peptide YY receptor activity (ortholog); INVOLVED IN cardiac left ventricle morphogenesis (ortholog); chemical synaptic transmission (ortholog); eating behavior (ortholog ); ASSOCIATED WITH absence epilepsy (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN 9+0 non-motile cilium (ortholog); GABA-ergic synapse (ortholog); membrane (ortholog) | | | | Green Monkey | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255009 | npy5r | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14273636 | NPY5R | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity (ortholog); pancreatic polypeptide receptor activity (ortholog); peptide YY receptor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); eating behavior (ortholog); generation of ovulation cycle rhythm (ortholog ); ASSOCIATED WITH absence epilepsy (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN 9+0 non-motile cilium (inferred); GABA-ergic synapse (inferred); membrane (inferred) | | | | Pig | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20865908 | NPY5R | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); neuropeptide binding (inferred); neuropeptide receptor activity (inferred); INVOLVED IN cardiac left ventricle morphogenesis (inferred); cell communication (inferred); chemical synaptic transmission (inferred); FOUND IN 9+0 non-motile cilium (inferred); GABA-ergic synapse (inferred); membrane (inferred) | | | | Green Monkey | 30 | symbol | gene, protein-coding |
| 625988461 | Npy5r | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity (ortholog); pancreatic polypeptide receptor activity (ortholog); peptide YY receptor activity (ortholog); INVOLVED IN cardiac left ventricle morphogenesis (ortholog); chemical synaptic transmission (ortholog); eating behavior (ortholog ); ASSOCIATED WITH absence epilepsy (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN 9+0 non-motile cilium (ortholog); GABA-ergic synapse (ortholog); membrane (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902031 | Npy5r | neuropeptide Y receptor Y5 | ENCODES a protein that exhibits neuropeptide Y receptor activity (ortholog); pancreatic polypeptide receptor activity (ortholog); peptide YY receptor activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); eating behavior (ortholog); generation of ovulation cycle rhythm (ortholog ); ASSOCIATED WITH absence epilepsy (ortholog); alcohol use disorder (ortholog); Alcohol Withdrawal Seizures (ortholog); FOUND IN 9+0 non-motile cilium (inferred); GABA-ergic synapse (inferred); membrane (inferred) | | | | Naked Mole-Rat | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259587 | npy5r.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155260008 | npy5r.S | | | | | | African Clawed Frog | | symbol | gene, null |