| 1558625 | Nkx6-3 | NK6 homeobox 3 | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate determinati on; epithelial cell differentiation; and negative regulation of stomach neuroendocrine cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; ear; and gut. Orthologous to human NKX6-3 (NK6 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 23643287 | 23648964 | Mouse | 52 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1597780 | Nkx6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell differentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride | 16 | 75570931 | 75576144 | Rat | 49 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1605569 | NKX6-3 | NK6 homeobox 3 | The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008] | 8 | 41645177 | 41650817 | Human | 42 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8926229 | Nkx6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell differentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog) | NW_004955536 | 1241110 | 1245504 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11958086 | NKX6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell dif ferentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog); FOUND IN nucleus (inferred) | 8 | 40889864 | 40895471 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12336846 | NKX6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell dif ferentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog); FOUND IN nucleus (inferred) | 16 | 23966621 | 23972714 | Dog | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12660440 | Nkx6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell dif ferentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog); FOUND IN nucleus (inferred) | NW_004936785 | 947275 | 952277 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625849230 | Nkx6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell differentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40826108 | NKX6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA binding (inferred) | | | | Bonobo | 1 | symbol | gene, protein-coding |
| 13943464 | NKX6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell dif ferentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913286 | Nkx6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell dif ferentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18650310 | NKX6-3 | NK6 homeobox 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell fate determination (ortholog); glandular epithelial cell dif ferentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254554 | nkx6-3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155237391 | nkx6-3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254553 | nkx6-3.S | | | | | | African Clawed Frog | | symbol | gene, null |