NKX6-3 (NK6 homeobox 3) - Rat Genome Database

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Gene: NKX6-3 (NK6 homeobox 3) Pan paniscus
Analyze
Symbol: NKX6-3
Name: NK6 homeobox 3
RGD ID: 11958086
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN cell fate determination (ortholog); enteroendocrine cell differentiation (ortholog); negative regulation of epithelial cell differentiation (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein Nkx-6.3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,097,801 - 60,103,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1835,815,052 - 35,820,659 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0840,889,864 - 40,895,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1838,339,634 - 38,340,603 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,339,634 - 38,343,769 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NKX6-3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,097,801 - 60,103,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1835,815,052 - 35,820,659 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0840,889,864 - 40,895,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1838,339,634 - 38,340,603 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,339,634 - 38,343,769 (-)Ensemblpanpan1.1panPan2
NKX6-3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38841,645,177 - 41,650,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl841,645,177 - 41,650,817 (-)EnsemblGRCh38hg38GRCh38
GRCh37841,502,696 - 41,508,336 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36841,622,986 - 41,624,035 (-)NCBINCBI36Build 36hg18NCBI36
Celera840,452,355 - 40,453,402 (-)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,031,601 - 40,032,605 (-)NCBIHuRef
CHM1_1841,552,037 - 41,553,080 (-)NCBICHM1_1
T2T-CHM13v2.0841,918,807 - 41,924,450 (-)NCBIT2T-CHM13v2.0
Nkx6-3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,643,287 - 23,648,964 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,643,285 - 23,648,964 (+)EnsemblGRCm39 Ensembl
GRCm38823,153,271 - 23,158,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl823,153,269 - 23,158,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv37824,263,743 - 24,269,420 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,618,816 - 24,624,493 (+)NCBIMGSCv36mm8
Celera824,649,266 - 24,655,141 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Nkx6-3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81675,570,931 - 75,576,144 (-)NCBIGRCr8
mRatBN7.21668,868,404 - 68,873,617 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1668,868,404 - 68,873,617 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,146,030 - 74,151,241 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01677,573,723 - 77,578,947 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01672,822,907 - 72,828,131 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01673,665,269 - 73,670,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1673,665,269 - 73,670,482 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,297,719 - 73,302,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,325,677 - 73,330,890 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1666,760,348 - 66,765,561 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
Nkx6-3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555361,240,946 - 1,245,651 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555361,241,110 - 1,245,504 (+)NCBIChiLan1.0ChiLan1.0
NKX6-3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,966,621 - 23,972,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,968,783 - 23,973,803 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1624,472,818 - 24,477,475 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,715,936 - 25,720,595 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,716,664 - 25,720,641 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11624,087,781 - 24,092,465 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,649,745 - 24,654,399 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,701,029 - 24,705,690 (+)NCBIUU_Cfam_GSD_1.0
Nkx6-3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,989,367 - 46,996,941 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785947,790 - 952,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936785947,275 - 952,277 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKX6-3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1710,743,318 - 10,747,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11710,743,350 - 10,747,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21712,175,762 - 12,179,733 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NKX6-3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1839,620,972 - 39,627,298 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl839,620,990 - 39,625,052 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660522,191,744 - 2,198,269 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkx6-3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247801,621,746 - 1,626,041 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247801,619,191 - 1,626,080 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034966998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_034966998   ⟹   XP_034822889
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2760,097,801 - 60,103,408 (-)NCBI
NHGRI_mPanPan1835,815,052 - 35,820,659 (-)NCBI
Mhudiblu_PPA_v0840,889,864 - 40,895,471 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034822889 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000008624.1
  ENSPPAP00000008627.1
Reference Protein Sequences
RefSeq Acc Id: XP_034822889   ⟸   XM_034966998
- UniProtKB: A0A2R8ZUI1 (UniProtKB/TrEMBL)
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027559 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000031260.1 UniProtKB/TrEMBL
  ENSPPAT00000031263.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  HTH_motif UniProtKB/TrEMBL
NCBI Gene NKX6-3 ENTREZGENE
PANTHER HOMEOBOX PROTEIN NKX UniProtKB/TrEMBL
  HOMEOBOX PROTEIN NKX-6.3 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
  HTHREPRESSR UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A2R8ZUI1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZXX0_PANPA UniProtKB/TrEMBL