| 3142 | Myl3 | myosin light chain 3 | ENCODES a protein that exhibits cytoskeletal motor activity; actin monomer binding (ortholog); INVOLVED IN cardiac muscle contraction; skeletal muscle tissue development; regulation of striated muscle contraction (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Familial Amyloid Polyneuropathies (ortholog); FOUND IN myosin complex; A band (ortholog); I band (ortholog); INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether | 8 | 119617077 | 119623215 | Rat | 134 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736456 | MYL3 | myosin light chain 3 | MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] | 3 | 46857872 | 46882182 | Human | 819 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736457 | Myl3 | myosin, light polypeptide 3 | Predicted to enable actin monomer binding activity and cytoskeletal motor activity. Predicted to be involved in several processes, including cardiac muscle contraction; regulation of the force of heart contraction; and ventricular cardiac muscle tissue morphogenesis. Predicted to be located in A ban d and I band. Predicted to be part of myosin II complex. Is expressed in several structures, including diaphragm; eye; heart; limb segment; and skeletal musculature. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Orthologous to human MYL3 (myosin light chain 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 110592746 | 110598870 | Mouse | 141 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9049972 | Myl3 | myosin light chain 3 | ENCODES a protein that exhibits actin monomer binding (ortholog); cytoskeletal motor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); regulation of striated muscle contraction (ortholog); regulation of the force of heart contraction (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Familial Amyloid Polyneuropathies (ortholog); FOUND IN A band (ortholog); I band (ortholog); myosin complex (ortholog) | NW_004955420 | 25308513 | 25311959 | Chinchilla | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11899506 | MYL3 | myosin light chain 3 | ENCODES a protein that exhibits cytoskeletal motor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); skeletal muscle tissue development (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Fam ilial Amyloid Polyneuropathies (ortholog); FOUND IN myosin complex (ortholog) | 3 | 46758058 | 46782425 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12292491 | MYL3 | myosin light chain 3 | ENCODES a protein that exhibits cytoskeletal motor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); skeletal muscle tissue development (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Fam ilial Amyloid Polyneuropathies (ortholog); FOUND IN myosin complex (ortholog) | 20 | 41941617 | 41947085 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12613584 | Myl3 | myosin light chain 3 | ENCODES a protein that exhibits cytoskeletal motor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); skeletal muscle tissue development (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Fam ilial Amyloid Polyneuropathies (ortholog); FOUND IN myosin complex (ortholog) | NW_004936596 | 649887 | 655110 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930172 | Myl3 | myosin light chain 3 | ENCODES a protein that exhibits cytoskeletal motor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); skeletal muscle tissue development (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Fam ilial Amyloid Polyneuropathies (ortholog); FOUND IN myosin complex (ortholog) | | | | Naked Mole-Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13992806 | MYL3 | myosin light chain 3 | ENCODES a protein that exhibits cytoskeletal motor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); skeletal muscle tissue development (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Fam ilial Amyloid Polyneuropathies (ortholog); FOUND IN myosin complex (ortholog) | | | | Pig | 41 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18590613 | MYL3 | myosin light chain 3 | ENCODES a protein that exhibits cytoskeletal motor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); skeletal muscle tissue development (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Fam ilial Amyloid Polyneuropathies (ortholog); FOUND IN myosin complex (ortholog) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625954069 | Myl3 | myosin light chain 3 | ENCODES a protein that exhibits actin monomer binding (ortholog); cytoskeletal motor activity (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); regulation of striated muscle contraction (ortholog); regulation of the force of heart contraction (ortholog); PARTICIPATES IN prostaglandin I2 signaling pathway; ASSOCIATED WITH cardiac amyloidosis (ortholog); cardiomyopathy (ortholog); Familial Amyloid Polyneuropathies (ortholog); FOUND IN A band (ortholog); I band (ortholog); myosin complex (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245056 | myl3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155253227 | myl3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246030 | myl3.S | | | | | | African Clawed Frog | | symbol | gene, null |