| 1308671 | Mtrr | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits [methionine synthase] reductase (NADPH) activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN cobalamin metabolic process (ortholog); folic acid metabolic process (ortholog); homocysteine catabolic process (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A | 1 | 36695376 | 36727341 | Rat | 160 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1318580 | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activi ty of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015] | 5 | 7850859 | 7901113 | Human | 293 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1318581 | Mtrr | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerate s a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Mutations in a similar gene in human have been associated with cblE complementation type homocystinuria-megaloblastic anemia and susceptibility to folate-sensitive neural tube defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2015] | 13 | 68708897 | 68730273 | Mouse | 165 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8839096 | Mtrr | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits [methionine synthase] reductase (NADPH) activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN cobalamin metabolic process (ortholog); folic acid metabolic process (ortholog); homocysteine catabolic process (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytosol (ortholog) | NW_004955504 | 5412290 | 5435409 | Chinchilla | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11676809 | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits molecular carrier activity (ortholog); INVOLVED IN S-adenosylmethionine cycle (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (o rtholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 5 | 8195868 | 8228071 | Bonobo | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12136836 | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits molecular carrier activity (ortholog); INVOLVED IN S-adenosylmethionine cycle (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (o rtholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytosol (ortholog) | 34 | 6068572 | 6119580 | Dog | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12699051 | Mtrr | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits molecular carrier activity (ortholog); INVOLVED IN S-adenosylmethionine cycle (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (o rtholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | NW_004936643 | 379790 | 410034 | Squirrel | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904434 | Mtrr | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits molecular carrier activity (ortholog); INVOLVED IN S-adenosylmethionine cycle (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (o rtholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Naked Mole-Rat | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18575529 | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits molecular carrier activity (ortholog); INVOLVED IN S-adenosylmethionine cycle (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (o rtholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246577 | mtrr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626098159 | Mtrr | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits [methionine synthase] reductase (NADPH) activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN cobalamin metabolic process (ortholog); folic acid metabolic process (ortholog); homocysteine catabolic process (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13861169 | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ENCODES a protein that exhibits molecular carrier activity (ortholog); INVOLVED IN S-adenosylmethionine cycle (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (o rtholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH ammonia | | | | Pig | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14373893 | mtrr-1 | | | | | | Roundworm | | symbol | gene, null |
| 155246576 | mtrr.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1314201 | MRRF | mitochondrial ribosome recycling factor | This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of riboso mes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016] | 9 | 122264882 | 122331337 | Human | 58 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314202 | Mrrf | mitochondrial ribosome recycling factor | Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosome disassembly and translation. Located in mitochondrion. Orthologous to human MRRF (mitochondrial ribosome recycling factor). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 36025672 | 36080296 | Mouse | 60 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
