| 1310306 | Mtmr4 | myotubularin related protein 4 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (ortholog); phosphatidylinositol-3-phosphate phosphatase activity (ortholog); INVOLVED IN response to denervation involved in regulation of muscle adaptation; midbody a bscission (ortholog); negative regulation of BMP signaling pathway (ortholog); ASSOCIATED WITH muscular atrophy; hereditary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium atom | 10 | 72890665 | 72913598 | Rat | 134 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321134 | MTMR4 | myotubularin related protein 4 | Enables several functions, including R-SMAD binding activity; phosphatidylinositol phosphate phosphatase activity; and protein phosphatase binding activity. Involved in several processes, including midbody abscission; negative regulation of transmembrane receptor protein serine/threonine kinase sign aling pathway; and phosphatidylinositol dephosphorylation. Located in early endosome membrane; late endosome membrane; and recycling endosome membrane. Is active in early phagosome membrane and endosome membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 58489537 | 58519047 | Human | 149 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1321135 | Mtmr4 | myotubularin related protein 4 | Predicted to enable molecular adaptor activity; phosphatase activity; and protein phosphatase binding activity. Predicted to be involved in several processes, including midbody abscission; phosphatidylinositol dephosphorylation; and regulation of phosphatidylinositol dephosphorylation. Predicted to be located in endosome. Predicted to be active in early phagosome membrane and endosome membrane. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 87482769 | 87507128 | Mouse | 148 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8738667 | Mtmr4 | myotubularin related protein 4 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (ortholog); phosphatidylinositol-3-phosphate phosphatase activity (ortholog); INVOLVED IN midbody abscission (ortholog); negative regulation of BMP signaling pathway (o rtholog); negative regulation of endocytic recycling (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); muscular atrophy (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog) | NW_004955451 | 4531966 | 4557528 | Chinchilla | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11816262 | MTMR4 | myotubularin related protein 4 | ENCODES a protein that exhibits R-SMAD binding (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of endocytic recycling (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH heredit ary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); muscular atrophy (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog) | 17 | 52564455 | 52592899 | Bonobo | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12232248 | MTMR4 | myotubularin related protein 4 | ENCODES a protein that exhibits R-SMAD binding (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of endocytic recycling (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH heredit ary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); muscular atrophy (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog) | 9 | 33110983 | 33136843 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12719362 | Mtmr4 | myotubularin related protein 4 | ENCODES a protein that exhibits R-SMAD binding (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of endocytic recycling (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH heredit ary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); muscular atrophy (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog) | NW_004936490 | 4611350 | 4638181 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626141548 | Mtmr4 | myotubularin related protein 4 | ENCODES a protein that exhibits molecular adaptor activity (ortholog); phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (ortholog); phosphatidylinositol-3-phosphate phosphatase activity (ortholog); INVOLVED IN midbody abscission (ortholog); negative regulation of BMP signaling pathway (o rtholog); negative regulation of endocytic recycling (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); muscular atrophy (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog) | | | | Black Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18369298 | MTMR4 | myotubularin related protein 4 | ENCODES a protein that exhibits R-SMAD binding (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of endocytic recycling (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH heredit ary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); muscular atrophy (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog) | | | | Green Monkey | 38 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18927698 | Mtmr4 | myotubularin related protein 4 | ENCODES a protein that exhibits R-SMAD binding (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of endocytic recycling (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH heredit ary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); muscular atrophy (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog) | | | | Naked Mole-Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255325 | mtmr4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14098909 | MTMR4 | myotubularin related protein 4 | ENCODES a protein that exhibits R-SMAD binding (ortholog); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of endocytic recycling (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH heredit ary breast ovarian cancer syndrome (ortholog); malignant mesothelioma (ortholog); muscular atrophy (ortholog); FOUND IN early endosome membrane (ortholog); early phagosome membrane (ortholog); endosome membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243638 | mtmr4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255324 | mtmr4.S | | | | | | African Clawed Frog | | symbol | gene, null |