| 1308071 | Pals1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN myelin assembly; protein localization to plasma membrane; central nervous system neuron development (ortholog); ASSOCIATED WITH Leber congenital amaurosis (ortholog); FOUND I N protein-containing complex; adherens junction (ortholog); apical part of cell (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil | 6 | 103327965 | 103384543 | Rat | 141 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317631 | PALS1 | protein associated with LIN7 1, MAGUK p55 family member | This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the component s of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] | 14 | 67241435 | 67336061 | Human | 145 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1317632 | Pals1 | protein associated with LIN7 1, MAGUK family member | Predicted to enable guanylate kinase activity; identical protein binding activity; and protein domain specific binding activity. Involved in nervous system development; protein localization to myelin sheath abaxonal region; and regulation of transforming growth factor beta receptor signaling pathway . Acts upstream of or within gene expression; plasma membrane organization; and protein localization. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and myelin sheath adaxonal region. Is active in apical part of cell. Is expressed in several structures, including central nervous system; early conceptus; and eye. Used to study Leber congenital amaurosis. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member). [provided by Alliance of Genome Resources, Apr 2025] | 12 | 78795606 | 78887488 | Mouse | 186 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8926827 | Pals1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN central nervous system neuron development (ortholog); cerebral cortex development (ortholog); gene expression (ortholog); ASSOCIATED WITH Leber congenital amaurosis (ortholog ); FOUND IN adherens junction (ortholog); apical part of cell (ortholog); cell junction (ortholog) | NW_004955466 | 2871445 | 2937296 | Chinchilla | 51 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11909931 | PALS1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); nucleotide binding (inferred); INVOLVED IN gene expression (ortholog); intracellular protein localization (ortholog); myelin assembly (ortholog); ASSOCIATED WITH Leber congenital amaurosis (ortholog); FOUND IN protein-containing complex (ortholog) | 14 | 47814896 | 47911206 | Bonobo | 56 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12108527 | PALS1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); nucleotide binding (inferred); INVOLVED IN central nervous system neuron development (ortholog); cerebral cortex development (ortholog); gene expression (ortholog); ASSOCIATED WITH Leber congenital amaurosi s (ortholog); FOUND IN adherens junction (ortholog); protein-containing complex (ortholog) | 8 | 41230230 | 41330017 | Dog | 50 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12513550 | Pals1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); nucleotide binding (inferred); INVOLVED IN gene expression (ortholog); intracellular protein localization (ortholog); myelin assembly (ortholog); ASSOCIATED WITH Leber congenital amaurosis (ortholog); FOUND IN protein-containing complex (ortholog) | NW_004936495 | 10636762 | 10729060 | Squirrel | 61 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14223680 | PALS1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); nucleotide binding (inferred); INVOLVED IN gene expression (ortholog); intracellular protein localization (ortholog); myelin assembly (ortholog); ASSOCIATED WITH Leber congenital amaurosis (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Pig | 65 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18669237 | PALS1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); nucleotide binding (inferred); INVOLVED IN gene expression (ortholog); intracellular protein localization (ortholog); myelin assembly (ortholog); ASSOCIATED WITH Leber congenital amaurosis (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Green Monkey | 60 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907969 | Pals1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); nucleotide binding (inferred); INVOLVED IN gene expression (ortholog); intracellular protein localization (ortholog); myelin assembly (ortholog); ASSOCIATED WITH Leber congenital amaurosis (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Naked Mole-Rat | 61 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 626027133 | Pals1 | protein associated with LIN7 1, MAGUK p55 family member | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN central nervous system neuron development (ortholog); cerebral cortex development (ortholog); gene expression (ortholog); ASSOCIATED WITH Leber congenital amaurosis (ortholog ); FOUND IN adherens junction (ortholog); apical part of cell (ortholog); cell junction (ortholog) | | | | Black Rat | 51 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16571437 | AL135978.1 | novel transcript, antisense to MPP5 | | | | | Human | | name | gene, lncrna |