| 631408 | Mmp8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding; endopeptidase activity; metallopeptidase activity; INVOLVED IN cellular response to lipopolysaccharide; ossification; positive regulation of neuroinflammatory response; ASSOCIATED WITH brain infarction; congestive heart failure; abdominal aortic a neurysm (ortholog); FOUND IN extracellular space; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate | 8 | 13008873 | 13018729 | Rat | 188 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732885 | Mmp8 | matrix metallopeptidase 8 | This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-d ependent endopeptidase enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016] | 9 | 7558430 | 7568487 | Mouse | 196 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1351878 | MMP8 | matrix metallopeptidase 8 | This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at d ifferent sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] | 11 | 102711796 | 102724954 | Human | 182 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8855615 | Mmp8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding (ortholog); endopeptidase activity (ortholog); metallopeptidase activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); endodermal cell differentiation (ortholog); ossification (ortholog); ASSOCIATED WITH abdominal aort ic aneurysm (ortholog); brain infarction (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog) | NW_004955412 | 5928997 | 5939012 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11940388 | MMP8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding (ortholog); metallopeptidase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN ossification (ortholog); positive regulation of microglial cell activation (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); brain infarction (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog) | 11 | 97650408 | 97663731 | Bonobo | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12203644 | MMP8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding (ortholog); metallopeptidase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN ossification (ortholog); positive regulation of microglial cell activation (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); brain infarction (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog) | 5 | 29036381 | 29047180 | Dog | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12552500 | Mmp8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding (ortholog); metallopeptidase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN ossification (ortholog); positive regulation of microglial cell activation (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); brain infarction (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog) | NW_004936551 | 5228950 | 5238948 | Squirrel | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625838581 | Mmp8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding (ortholog); endopeptidase activity (ortholog); metallopeptidase activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); endodermal cell differentiation (ortholog); ossification (ortholog); ASSOCIATED WITH abdominal aort ic aneurysm (ortholog); brain infarction (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13879342 | MMP8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding (ortholog); metallopeptidase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN ossification (ortholog); positive regulation of microglial cell activation (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); brain infarction (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH zearalenone | | | | Pig | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18615001 | MMP8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding (ortholog); metallopeptidase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN ossification (ortholog); positive regulation of microglial cell activation (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); brain infarction (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903385 | Mmp8 | matrix metallopeptidase 8 | ENCODES a protein that exhibits calcium ion binding (ortholog); metallopeptidase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN ossification (ortholog); positive regulation of microglial cell activation (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); brain infarction (ortholog); breast cancer (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238058 | mmp8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155238057 | mmp8.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239921 | mmp8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16567899 | AP001486.3 | matrix metallopeptidase 8 (neutrophil collagenase) (MMP8) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
