MMP8 (matrix metallopeptidase 8) - Rat Genome Database

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Gene: MMP8 (matrix metallopeptidase 8) Canis lupus familiaris
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Symbol: MMP8
Name: matrix metallopeptidase 8
RGD ID: 12203644
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); metallopeptidase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN ossification (ortholog); positive regulation of microglial cell activation (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); asphyxiating thoracic dystrophy (ortholog); ataxia telangiectasia (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: matrix metallopeptidase 8 (neutrophil collagenase); neutrophil collagenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,036,381 - 29,047,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,035,820 - 29,046,808 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,984,875 - 28,995,648 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,087,831 - 29,098,581 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,087,795 - 29,098,209 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,122,825 - 29,133,583 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,002,064 - 29,012,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,177,264 - 29,188,014 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MMP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,036,381 - 29,047,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,035,820 - 29,046,808 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,984,875 - 28,995,648 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,087,831 - 29,098,581 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,087,795 - 29,098,209 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,122,825 - 29,133,583 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,002,064 - 29,012,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,177,264 - 29,188,014 (+)NCBIUU_Cfam_GSD_1.0
MMP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,711,796 - 102,724,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,711,796 - 102,727,050 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,582,527 - 102,595,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,088,540 - 102,100,868 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,088,539 - 102,100,868NCBI
Celera1199,743,725 - 99,756,878 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,509,472 - 98,522,626 (-)NCBIHuRef
CHM1_111102,465,498 - 102,478,648 (-)NCBICHM1_1
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBIT2T-CHM13v2.0
Mmp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,558,430 - 7,568,487 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,558,457 - 7,568,486 (+)EnsemblGRCm39 Ensembl
GRCm3897,558,429 - 7,568,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,558,456 - 7,568,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,558,429 - 7,568,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,558,460 - 7,568,485 (+)NCBIMGSCv36mm8
Celera94,948,941 - 4,958,998 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,008,873 - 13,018,729 (+)NCBIGRCr8
mRatBN7.284,724,009 - 4,733,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,724,029 - 4,733,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,683,788 - 8,692,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,981,565 - 6,990,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,983,774 - 4,992,630 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,768,808 - 5,777,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,768,811 - 5,778,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,771,659 - 5,780,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,402,124 - 4,410,976 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,402,123 - 4,410,976 (+)NCBI
Celera86,283,716 - 6,292,568 (+)NCBICelera
Cytogenetic Map8q11NCBI
Mmp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,928,997 - 5,939,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,928,997 - 5,939,012 (-)NCBIChiLan1.0ChiLan1.0
MMP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,503,121 - 103,516,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,591,436 - 104,604,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,650,408 - 97,663,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,143,372 - 101,156,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,143,268 - 101,156,736 (-)Ensemblpanpan1.1panPan2
Mmp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,297,496 - 86,305,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,228,950 - 5,238,948 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,228,950 - 5,238,948 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,384,033 - 33,396,947 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,384,034 - 33,397,637 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,330,738 - 37,343,699 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,097,620 - 94,110,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,097,896 - 94,109,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,764,839 - 31,777,953 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878164,171 - 175,654 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878124,396 - 174,584 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MMP8
115 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 6 4
Below cutoff 2 5 21 6 6 6 5 9 7 6 6

Sequence


RefSeq Acc Id: ENSCAFT00000023896   ⟹   ENSCAFP00000022184
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl529,035,820 - 29,046,808 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845001511   ⟹   ENSCAFP00845001189
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl529,087,795 - 29,098,209 (+)Ensembl
RefSeq Acc Id: XM_038475212   ⟹   XP_038331140
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1529,122,825 - 29,133,583 (+)NCBI
RefSeq Acc Id: XM_038536353   ⟹   XP_038392281
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0529,177,264 - 29,188,014 (+)NCBI
RefSeq Acc Id: XM_038600559   ⟹   XP_038456487
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0529,002,064 - 29,012,820 (+)NCBI
RefSeq Acc Id: XM_038665091   ⟹   XP_038521019
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0529,087,831 - 29,098,581 (+)NCBI
RefSeq Acc Id: XM_546547   ⟹   XP_546547
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1529,036,381 - 29,047,180 (+)NCBI
Dog10K_Boxer_Tasha528,984,875 - 28,995,648 (+)NCBI
Sequence:
RefSeq Acc Id: XP_546547   ⟸   XM_546547
- UniProtKB: A0A8I3MXC2 (UniProtKB/TrEMBL),   A0A8P0SJK1 (UniProtKB/TrEMBL),   A0A8C0K9M4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000022184   ⟸   ENSCAFT00000023896
RefSeq Acc Id: XP_038331140   ⟸   XM_038475212
RefSeq Acc Id: XP_038456487   ⟸   XM_038600559
RefSeq Acc Id: XP_038521019   ⟸   XM_038665091
- UniProtKB: A0A8I3MXC2 (UniProtKB/TrEMBL),   A0A8P0SJK1 (UniProtKB/TrEMBL),   A0A8C0K9M4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038392281   ⟸   XM_038536353
- UniProtKB: A0A8C0K9M4 (UniProtKB/TrEMBL),   A0A8I3MXC2 (UniProtKB/TrEMBL),   A0A8P0SJK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001189   ⟸   ENSCAFT00845001511
Protein Domains
Peptidase metallopeptidase

Promoters
RGD ID:13683189
Promoter ID:EPDNEW_C1256
Type:single initiation site
Name:MMP8_1
Description:matrix metallopeptidase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1529,036,452 - 29,036,512EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023335 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845000899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023896.5 UniProtKB/TrEMBL
  ENSCAFT00845001511 ENTREZGENE
  ENSCAFT00845001511.1 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/TrEMBL
  M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/TrEMBL
KEGG Report cfa:489429 UniProtKB/TrEMBL
NCBI Gene MMP8 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/TrEMBL
  PTHR10201:SF137 UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/TrEMBL
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
SMART SM00120 UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF47090 UniProtKB/TrEMBL
  SSF50923 UniProtKB/TrEMBL
UniProt A0A8C0K9M4 ENTREZGENE
  A0A8I3MXC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SJK1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43289 ENTREZGENE