| 1311862 | Mgrn1 | mahogunin ring finger 1 | ENCODES a protein that exhibits protein sequestering activity (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN endosome to lysosome transport (ortholog); heart development (ortholog); in utero embryonic development (ortholog); P ARTICIPATES IN melanocortin system pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride | 10 | 11142626 | 11194773 | Rat | 123 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1353673 | MGRN1 | mahogunin ring finger 1 | Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 4624826 | 4690972 | Human | 113 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1558478 | Mgrn1 | mahogunin, ring finger 1 | Enables ubiquitin protein ligase activity. Involved in negative regulation of smoothened signaling pathway. Acts upstream of or within several processes, including heart development; protein polyubiquitination; and smoothened signaling pathway. Part of ubiquitin ligase complex. Is expressed in sever al structures, including genitourinary system; heart; node; and skin. Orthologous to human MGRN1 (mahogunin ring finger 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 4703964 | 4756160 | Mouse | 176 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8957110 | Mgrn1 | mahogunin ring finger 1 | ENCODES a protein that exhibits protein sequestering activity (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN endosome to lysosome transport (ortholog); heart development (ortholog); in utero embryonic development (ortholog); P ARTICIPATES IN melanocortin system pathway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog) | NW_004955442 | 12780795 | 12823716 | Chinchilla | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11720447 | MGRN1 | mahogunin ring finger 1 | ENCODES a protein that exhibits metal ion binding (inferred); protein sequestering activity (inferred); transferase activity (inferred); INVOLVED IN heart development (ortholog); in utero embryonic development (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN melanocortin system pat hway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | 16 | 3550352 | 3615693 | Bonobo | 54 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12144208 | MGRN1 | mahogunin ring finger 1 | ENCODES a protein that exhibits metal ion binding (inferred); protein sequestering activity (inferred); transferase activity (inferred); INVOLVED IN heart development (ortholog); in utero embryonic development (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN melanocortin system pat hway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN plasma membrane (ortholog); ubiquitin ligase complex (ortholog) | 6 | 36716071 | 36775893 | Dog | 51 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12547195 | Mgrn1 | mahogunin ring finger 1 | ENCODES a protein that exhibits metal ion binding (inferred); protein sequestering activity (inferred); transferase activity (inferred); INVOLVED IN heart development (ortholog); in utero embryonic development (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN melanocortin system pat hway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | NW_004936530 | 4647550 | 4693143 | Squirrel | 54 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625961222 | Mgrn1 | mahogunin ring finger 1 | ENCODES a protein that exhibits protein sequestering activity (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN endosome to lysosome transport (ortholog); heart development (ortholog); in utero embryonic development (ortholog); P ARTICIPATES IN melanocortin system pathway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); early endosome (ortholog) | | | | Black Rat | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18922101 | Mgrn1 | mahogunin ring finger 1 | ENCODES a protein that exhibits protein sequestering activity (ortholog); INVOLVED IN heart development (ortholog); in utero embryonic development (ortholog); negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN melanocortin sys tem pathway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN cytosol (ortholog); ubiquitin ligase complex (ortholog) | | | | Naked Mole-Rat | 47 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18790081 | MGRN1 | mahogunin ring finger 1 | ENCODES a protein that exhibits metal ion binding (inferred); protein sequestering activity (inferred); transferase activity (inferred); INVOLVED IN heart development (ortholog); in utero embryonic development (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN melanocortin system pat hway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN ubiquitin ligase complex (ortholog) | | | | Green Monkey | 54 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155250910 | mgrn1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13990504 | MGRN1 | mahogunin ring finger 1 | ENCODES a protein that exhibits metal ion binding (inferred); protein sequestering activity (inferred); transferase activity (inferred); INVOLVED IN heart development (ortholog); in utero embryonic development (ortholog); protein polyubiquitination (ortholog); PARTICIPATES IN melanocortin system pat hway; ASSOCIATED WITH hyperglycemia (ortholog); hyperinsulinism (ortholog); obesity (ortholog); FOUND IN plasma membrane (ortholog); ubiquitin ligase complex (ortholog) | | | | Pig | 51 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155249808 | mgrn1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 617301269 | MGRN1-AS1 | MGRN1 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 16563277 | AC023830.1 | novel transcript, antisense to MGRN1 | | | | | Human | | name | gene, lncrna |
| 18926528 | LOC101697476 | E3 ubiquitin-protein ligase MGRN1 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |