| 1311070 | Me3 | malic enzyme 3 | ENCODES a protein that exhibits malate dehydrogenase (decarboxylating) (NADP+) activity (ortholog); malic enzyme activity (ortholog); NADP+ binding (ortholog); INVOLVED IN malate metabolic process (ortholog); pyruvate biosynthetic process (ortholog); PARTICIPATES IN pyruvate metabolic pathway; FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide | 1 | 152946595 | 153148026 | Rat | 143 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1322332 | ME3 | malic enzyme 3 | Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent i soform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] | 11 | 86434930 | 86672616 | Human | 151 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553653 | Me3 | malic enzyme 3, NADP(+)-dependent, mitochondrial | Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; integumental system; metanephro s; and sensory organ. Orthologous to human ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 89281492 | 89503423 | Mouse | 152 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8878598 | Me3 | malic enzyme 3 | ENCODES a protein that exhibits malate dehydrogenase (decarboxylating) (NADP+) activity (ortholog); malic enzyme activity (ortholog); NADP+ binding (ortholog); INVOLVED IN malate metabolic process (ortholog); pyruvate biosynthetic process (ortholog); FOUND IN mitochondrial matrix (ortholog); mitocho ndrion (ortholog) | NW_004955414 | 6335411 | 6555494 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11832068 | ME3 | malic enzyme 3 | ENCODES a protein that exhibits malate dehydrogenase (decarboxylating) (NADP+) activity (inferred); malic enzyme activity (inferred); metal ion binding (inferred); INVOLVED IN malate metabolic process (inferred); pyruvate biosynthetic process (inferred); FOUND IN mitochondrial matrix (inferred); mit ochondrion (inferred) | 11 | 81490947 | 81728589 | Bonobo | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12403685 | ME3 | malic enzyme 3 | ENCODES a protein that exhibits malate dehydrogenase (decarboxylating) (NADP+) activity (inferred); malic enzyme activity (inferred); metal ion binding (inferred); INVOLVED IN malate metabolic process (inferred); pyruvate biosynthetic process (inferred); FOUND IN mitochondrion (ortholog); INTERACTS WITH bisphenol A | 21 | 12813052 | 13105805 | Dog | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12658309 | Me3 | malic enzyme 3 | ENCODES a protein that exhibits malate dehydrogenase (decarboxylating) (NADP+) activity (inferred); malic enzyme activity (inferred); metal ion binding (inferred); INVOLVED IN malate metabolic process (inferred); pyruvate biosynthetic process (inferred); FOUND IN mitochondrial matrix (inferred); mit ochondrion (inferred) | NW_004936498 | 14216510 | 14422936 | Squirrel | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18708505 | ME3 | malic enzyme 3 | ENCODES a protein that exhibits malate dehydrogenase (decarboxylating) (NADP+) activity (inferred); malic enzyme activity (inferred); metal ion binding (inferred); INVOLVED IN malate metabolic process (inferred); pyruvate biosynthetic process (inferred); FOUND IN mitochondrial matrix (inferred); mit ochondrion (inferred) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14155135 | ME3 | malic enzyme 3 | ENCODES a protein that exhibits malate dehydrogenase (decarboxylating) (NADP+) activity (inferred); malic enzyme activity (inferred); metal ion binding (inferred); INVOLVED IN malate metabolic process (inferred); pyruvate biosynthetic process (inferred); FOUND IN mitochondrion (ortholog) | | | | Pig | 18 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155245105 | me3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18899769 | Me3 | malic enzyme 3 | ENCODES a protein that exhibits NADP+ binding (ortholog); INVOLVED IN pyruvate biosynthetic process (ortholog); FOUND IN mitochondrial matrix (ortholog) | | | | Naked Mole-Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256871 | me3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 14390099 | ME3-DT | ME3 divergent transcript | | 11 | 86672237 | 86753297 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 616940554 | ME3-AS1 | Me3 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 1323670 | PCDHGA5 | protocadherin gamma subfamily A, 5 | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] | 5 | 141364162 | 141512975 | Human | 41 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16560401 | AP001831.1 | novel transcript, antisense to ME3 | | | | | Human | | name | gene, lncrna |
| 14376053 | me31B | | | | | | Fly | | symbol | gene, null |
| 1552424 | Btrc | beta-transducin repeat containing protein | Enables beta-catenin binding activity; protein phosphorylated amino acid binding activity; and ubiquitin protein ligase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein modification process; and regulation of canonica l Wnt signaling pathway. Acts upstream of or within several processes, including mammary gland epithelium development; protein K48-linked ubiquitination; and regulation of canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system; and respiratory system. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 45352119 | 45521782 | Mouse | 198 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
