| 1359371 | Mavs | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); antiviral innate immune response (ortholog); cellular response to exogenous dsRNA (o rtholog); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil | 3 | 138904673 | 138919129 | Rat | 199 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606258 | MAVS | mitochondrial antiviral signaling protein | This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. [provided by RefSeq, Jul 2020] | 20 | 3846834 | 3876118 | Human | 233 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1614930 | Mavs | mitochondrial antiviral signaling protein | Enables signaling adaptor activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within positive regulat ion of cytokine production and regulation of defense response. Located in mitochondrion and peroxisome. Is expressed in cerebral cortex ventricular layer. Orthologous to human MAVS (mitochondrial antiviral signaling protein). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 131075445 | 131089945 | Mouse | 268 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8923210 | Mavs | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); antiviral innate immune response (ortholog); cellular response to exogenous dsRNA (o rtholog); ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog) | NW_004955415 | 14691918 | 14704782 | Chinchilla | 134 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11727106 | MAVS | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (inferred); DNA-binding transcription factor binding (inferred); identical protein binding (inferred); INVOLVED IN antiviral innate immune response (ortholog); cellular response to interferon-beta (ortholog); positive regulation of defense response to virus by host (ortholog); ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog) | 20 | 3885044 | 3903554 | Bonobo | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12182691 | MAVS | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (inferred); DNA-binding transcription factor binding (inferred); identical protein binding (inferred); INVOLVED IN antiviral innate immune response (ortholog); cellular response to interferon-beta (ortholog); positive regulation of defense response to virus by host (ortholog); ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog) | 24 | 17510209 | 17529286 | Dog | 136 | symbol | gene, protein-coding, INFERRED [RefSeq] |
| 12649917 | Mavs | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (inferred); DNA-binding transcription factor binding (inferred); identical protein binding (inferred); INVOLVED IN antiviral innate immune response (ortholog); cellular response to interferon-beta (ortholog); positive regulation of defense response to virus by host (ortholog); ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog) | NW_004936485 | 14842778 | 14859163 | Squirrel | 135 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910192 | Mavs | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); antiviral innate immune response (ortholog); cellular response to exogenous dsRNA (o rtholog); ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog); mitochondrion (ortholog) | | | | Naked Mole-Rat | 129 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626096960 | Mavs | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); antiviral innate immune response (ortholog); cellular response to exogenous dsRNA (o rtholog); ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog) | | | | Black Rat | 134 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285034497 | mavs | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18755995 | MAVS | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (inferred); DNA-binding transcription factor binding (inferred); identical protein binding (inferred); INVOLVED IN antiviral innate immune response (ortholog); cellular response to interferon-beta (ortholog); positive regulation of defense response to virus by host (ortholog); ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog) | | | | Green Monkey | 136 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14028445 | MAVS | mitochondrial antiviral signaling protein | ENCODES a protein that exhibits CARD domain binding (inferred); DNA-binding transcription factor binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of transcription by RNA polymerase II; antiviral innate immune response (ortholog); cellular response to interfer on-beta (ortholog); ASSOCIATED WITH influenza (ortholog); influenza A (ortholog); Metapneumovirus infections (ortholog); FOUND IN cytoplasm; mitochondrial membrane; mitochondrial outer membrane (ortholog); INTERACTS WITH mycotoxin | | | | Pig | 142 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 596935989 | mavs.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934138 | mavs.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596936055 | mavs.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933694 | mavs.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 285035508 | mavs.L | | | | | | African Clawed Frog | | symbol | gene, null |