| 3025 | Lypla1 | lysophospholipase 1 | ENCODES a protein that exhibits phosphatidylcholine lysophospholipase A1 activity; glycerophospholipase activity (ortholog); lipase activity (ortholog); INVOLVED IN fatty acid transport (ortholog); negative regulation of aggrephagy (ortholog); negative regulation of Golgi to plasma membrane protein transport (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 5 | 19477408 | 19506568 | Rat | 170 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 735384 | LYPLA1 | lysophospholipase 1 | This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013] | 8 | 54042987 | 54101947 | Human | 154 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735385 | Lypla1 | lysophospholipase 1 | Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Acts upstream of or within negative regulation of Golgi to plasma membrane protein transport. Located in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gu t; and skeleton. Orthologous to human LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 4878046 | 4916958 | Mouse | 184 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8913972 | Lypla1 | lysophospholipase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); lipase activity (ortholog); palmitoyl-(protein) hydrolase activity (ortholog); INVOLVED IN fatty acid transport (ortholog); negative regulation of aggrephagy (ortholog); negative regulation of Golgi to plasma membrane protein transport (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog) | NW_004955454 | 13356851 | 13385110 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11737105 | LYPLA1 | lysophospholipase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); lipase activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN fatty acid transport (ortholog); negative regulation of aggrephagy (ortholog); negative regulation of Golgi to plasma membra ne protein transport (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN cytosol (ortholog); mitochondrion (ortholog); plasma membrane (ortholog) | 8 | 50474238 | 50529167 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12310893 | LYPLA1 | lysophospholipase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); lipase activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN fatty acid transport (ortholog); negative regulation of aggrephagy (ortholog); negative regulation of Golgi to plasma membra ne protein transport (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN cytosol (ortholog); mitochondrion (ortholog); plasma membrane (ortholog) | 29 | 5656376 | 5696901 | Dog | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12507867 | Lypla1 | lysophospholipase 1 | ENCODES a protein that exhibits phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN negative regulation of Golgi to plasma membrane protein transport (ortholog); protein depalmitoylation (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN mitochondrion ( ortholog); plasma membrane (ortholog) | NW_004936496 | 937918 | 971315 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14256361 | LYPLA1 | lysophospholipase 1 | ENCODES a protein that exhibits phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN negative regulation of Golgi to plasma membrane protein transport (ortholog); protein depalmitoylation (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN mitochondrion ( ortholog); plasma membrane (ortholog) | | | | Pig | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18492380 | LYPLA1 | lysophospholipase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); lipase activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN fatty acid transport (ortholog); negative regulation of aggrephagy (ortholog); negative regulation of Golgi to plasma membra ne protein transport (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN cytosol (ortholog); mitochondrion (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626054231 | Lypla1 | lysophospholipase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); lipase activity (ortholog); palmitoyl-(protein) hydrolase activity (ortholog); INVOLVED IN fatty acid transport (ortholog); negative regulation of aggrephagy (ortholog); negative regulation of Golgi to plasma membrane protein transport (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928828 | Lypla1 | lysophospholipase 1 | ENCODES a protein that exhibits glycerophospholipase activity (ortholog); lipase activity (ortholog); phosphatidylcholine lysophospholipase A1 activity (ortholog); INVOLVED IN fatty acid transport (ortholog); negative regulation of aggrephagy (ortholog); negative regulation of Golgi to plasma membra ne protein transport (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; FOUND IN cytosol (ortholog); mitochondrion (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239251 | lypla1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155241610 | lypla1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258008 | lypla1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2321308 | Lypla1-ps1 | lysophospholipase 1, pseudogene 1 | | 8 | 26145554 | 26146237 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1595698 | Lypla1-ps2 | lysophospholipase 1, pseudogene 2 | | 20 | 55537732 | 55539273 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41375961 | Lypla1-ps3 | lysophospholipase 1, pseudogene 3 | | 1 | 67522356 | 67523207 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41277812 | Lypla1-ps4 | lysophospholipase 1, pseudogene 4 | | 1 | 67561072 | 67561763 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 401965425 | LYPLA1-TCEA1 | LYPLA1-TCEA1 readthrough | This locus represents naturally occurring read-through transcription between the neighboring LYPLA1 (acyl-protein thioesterase 1) and TCEA1 (transcription elongation factor A protein 1) genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. [provided by RefSeq, Nov 2023] | 8 | 53966556 | 54101947 | Human | 15 | symbol , GTEx , COSMIC , name , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 6484020 | LYPLA1P1 | LYPLA1 pseudogene 1 | | 7 | 123229871 | 123230852 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6484055 | LYPLA1P2 | LYPLA1 pseudogene 2 | | 4 | 110944916 | 110945876 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 6484050 | LYPLA1P3 | LYPLA1 pseudogene 3 | | 6 | 71164980 | 71167456 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16563018 | AC100821.2 | novel transcript, overlapping to LYPLA1 | | | | | Human | | name | gene, lncrna |