Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of LYPLA1 mRNA] | CTD | PMID:31150632 | 1,1-dichloroethene | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of LYPLA1 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of LYPLA1 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of LYPLA1 mRNA | CTD | PMID:17942748 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Lypla1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LYPLA1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of LYPLA1 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of LYPLA1 mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of LYPLA1 mRNA | CTD | PMID:22574217 | 2,4,6-tribromophenol | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2-hydroxypropanoic acid | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of LYPLA1 mRNA | CTD | PMID:30851411 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:23196670 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1 and 2-dithiol-3-thione results in decreased expression of LYPLA1 mRNA | CTD | PMID:19162173 | 5-fluorouracil | multiple interactions | ISO | LYPLA1 (Homo sapiens) | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of LYPLA1 mRNA] | CTD | PMID:15016801 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of LYPLA1 mRNA | CTD | PMID:24780913 | 9-cis-retinoic acid | decreases expression | EXP | | 6480464 | Alitretinoin results in decreased expression of LYPLA1 mRNA | CTD | PMID:16648578 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of LYPLA1 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | LYPLA1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of LYPLA1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of LYPLA1 mRNA | CTD | PMID:32699268 | alpha-pinene | multiple interactions | ISO | LYPLA1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of LYPLA1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of LYPLA1 mRNA | CTD | PMID:32699268 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of LYPLA1 mRNA | CTD | PMID:16483693 | antirheumatic drug | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of LYPLA1 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of LYPLA1 mRNA | CTD | PMID:33212167 | aristolochic acid A | increases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of LYPLA1 protein | CTD | PMID:33212167 | Aroclor 1254 | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of LYPLA1 mRNA | CTD | PMID:23650126 | arsane | affects methylation | ISO | LYPLA1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of LYPLA1 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | LYPLA1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of LYPLA1 gene | CTD | PMID:25304211 | arsenous acid | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of LYPLA1 protein | CTD | PMID:19364129 | benzo[a]pyrene | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of LYPLA1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | LYPLA1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of LYPLA1 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | bexarotene | decreases expression | EXP | | 6480464 | bexarotene results in decreased expression of LYPLA1 mRNA | CTD | PMID:16648578 | bisphenol A | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of LYPLA1 mRNA | CTD | PMID:26063408 | bisphenol A | increases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of LYPLA1 protein | CTD | PMID:37567409 | bisphenol A | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of LYPLA1 mRNA and bisphenol A results in decreased expression of LYPLA1 protein | CTD | PMID:29275510 and PMID:34186270 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LYPLA1 mRNA | CTD | PMID:25181051 | Bisphenol B | increases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of LYPLA1 protein | CTD | PMID:34186270 | bisphenol F | increases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of LYPLA1 protein | CTD | PMID:34186270 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of LYPLA1 mRNA | CTD | PMID:19167457 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of LYPLA1 promoter | CTD | PMID:22457795 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of LYPLA1 mRNA | CTD | PMID:33453195 | calcitriol | multiple interactions | EXP | | 6480464 | [Calcium co-treated with Calcitriol] affects the expression of LYPLA1 mRNA | CTD | PMID:15913539 | calcium atom | multiple interactions | EXP | | 6480464 | [Calcium co-treated with Calcitriol] affects the expression of LYPLA1 mRNA | CTD | PMID:15913539 | calcium(0) | multiple interactions | EXP | | 6480464 | [Calcium co-treated with Calcitriol] affects the expression of LYPLA1 mRNA | CTD | PMID:15913539 | carbon nanotube | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of LYPLA1 mRNA | CTD | PMID:25554681 | cisplatin | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Cisplatin results in increased expression of LYPLA1 mRNA | CTD | PMID:15464296 and PMID:15471895 | clofibrate | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of LYPLA1 mRNA | CTD | PMID:17585979 | clofibrate | multiple interactions | ISO | Lypla1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of LYPLA1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LYPLA1 mRNA] | CTD | PMID:17585979 | copper(II) sulfate | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of LYPLA1 mRNA | CTD | PMID:19549813 | diarsenic trioxide | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of LYPLA1 protein | CTD | PMID:19364129 | Diisodecyl phthalate | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | diisodecyl phthalate results in increased expression of LYPLA1 mRNA | CTD | PMID:25270620 | diquat | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Diquat results in decreased expression of LYPLA1 mRNA | CTD | PMID:36851058 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of LYPLA1 mRNA | CTD | PMID:21551480 | doxorubicin | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of LYPLA1 mRNA | CTD | PMID:29803840 | elemental selenium | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Selenium results in decreased expression of LYPLA1 mRNA | CTD | PMID:19244175 | epoxiconazole | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of LYPLA1 mRNA | CTD | PMID:35436446 | ethanol | affects splicing | ISO | Lypla1 (Mus musculus) | 6480464 | Ethanol affects the splicing of LYPLA1 mRNA | CTD | PMID:30319688 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of LYPLA1 protein | CTD | PMID:33656234 | flavonoids | increases expression | EXP | | 6480464 | Flavonoids results in increased expression of LYPLA1 mRNA | CTD | PMID:18035473 | folic acid | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of LYPLA1 mRNA | CTD | PMID:25629700 | folpet | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | folpet results in increased expression of LYPLA1 mRNA | CTD | PMID:31558096 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of LYPLA1 mRNA | CTD | PMID:22061828 and PMID:33387578 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of LYPLA1 mRNA | CTD | PMID:24136188 | iron atom | decreases expression | EXP | | 6480464 | Iron deficiency results in decreased expression of LYPLA1 mRNA | CTD | PMID:19821111 | iron(0) | decreases expression | EXP | | 6480464 | Iron deficiency results in decreased expression of LYPLA1 mRNA | CTD | PMID:19821111 | ivermectin | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of LYPLA1 protein | CTD | PMID:32959892 | lithocholic acid | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Lithocholic Acid results in decreased expression of LYPLA1 mRNA | CTD | PMID:20359477 and PMID:21480330 | lithocholic acid | multiple interactions | ISO | Lypla1 (Mus musculus) | 6480464 | [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LYPLA1 mRNA | CTD | PMID:20359477 | methidathion | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | methidathion results in decreased expression of LYPLA1 mRNA | CTD | PMID:34813904 | methylseleninic acid | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | methylselenic acid results in decreased expression of LYPLA1 mRNA | CTD | PMID:18548127 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of LYPLA1 mRNA | CTD | PMID:20360939 | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of LYPLA1 mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | LYPLA1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of LYPLA1 mRNA more ... | CTD | PMID:32699268 | paracetamol | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Acetaminophen results in increased expression of LYPLA1 mRNA | CTD | PMID:17585979 | paracetamol | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of LYPLA1 mRNA | CTD | PMID:25704631 | paracetamol | multiple interactions | ISO | Lypla1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of LYPLA1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LYPLA1 mRNA] | CTD | PMID:17585979 | paracetamol | affects expression | ISO | Lypla1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of LYPLA1 mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | increases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of LYPLA1 protein | CTD | PMID:26879310 | phenylpropanolamine | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Phenylpropanolamine results in increased expression of LYPLA1 mRNA | CTD | PMID:16465460 | phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of LYPLA1 mRNA | CTD | PMID:20345932 | pregnenolone 16alpha-carbonitrile | multiple interactions | ISO | Lypla1 (Mus musculus) | 6480464 | [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LYPLA1 mRNA | CTD | PMID:20359477 | rac-lactic acid | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of LYPLA1 mRNA | CTD | PMID:30851411 | rotenone | increases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Rotenone results in increased expression of LYPLA1 mRNA | CTD | PMID:33512557 | selenium atom | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Selenium results in decreased expression of LYPLA1 mRNA | CTD | PMID:19244175 | sodium dichromate | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | sodium bichromate results in increased expression of LYPLA1 mRNA | CTD | PMID:31558096 | sodium dodecyl sulfate | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Sodium Dodecyl Sulfate results in decreased expression of LYPLA1 protein | CTD | PMID:21469165 | tert-butyl hydroperoxide | decreases response to substance | ISO | Lypla1 (Mus musculus) | 6480464 | LYPLA1 protein results in decreased susceptibility to tert-Butylhydroperoxide | CTD | PMID:15003993 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of LYPLA1 mRNA] | CTD | PMID:31150632 | tetrachloromethane | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of LYPLA1 mRNA | CTD | PMID:31919559 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of LYPLA1 mRNA | CTD | PMID:31150632 | thapsigargin | decreases expression | ISO | Lypla1 (Mus musculus) | 6480464 | Thapsigargin results in decreased expression of LYPLA1 protein | CTD | PMID:24648495 | Tributyltin oxide | decreases expression | EXP | | 6480464 | bis(tri-n-butyltin)oxide results in decreased expression of LYPLA1 mRNA | CTD | PMID:17553608 | triptonide | increases expression | ISO | Lypla1 (Mus musculus) | 6480464 | triptonide results in increased expression of LYPLA1 mRNA | CTD | PMID:33045310 | undecane | decreases expression | EXP | | 6480464 | undecane results in decreased expression of LYPLA1 protein | CTD | PMID:17337753 | valproic acid | decreases expression | ISO | LYPLA1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of LYPLA1 mRNA | CTD | PMID:23179753 | zinc atom | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of LYPLA1 mRNA | CTD | PMID:12672911 and PMID:15671213 | zinc(0) | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of LYPLA1 mRNA | CTD | PMID:12672911 and PMID:15671213 | |