| 1312017 | Lynx1 | Ly6/neurotoxin 1 | ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); acetylcholine receptor inhibitor activity (ortholog); acetylcholine receptor regulator activity (ortholog); INVOLVED IN regulation of neurotransmitter receptor activity (ortholog); synaptic transmission, cholinergic (ortholog ); FOUND IN membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 108521783 | 108527012 | Rat | 103 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323781 | Lynx1 | Ly6/neurotoxin 1 | Enables acetylcholine receptor inhibitor activity and ion channel inhibitor activity. Acts upstream of or within cholinergic synaptic transmission. Located in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and respiratory system. Orthologous to several human genes including LYNX1 (Ly6/neurotoxin 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 74619705 | 74624828 | Mouse | 121 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1604308 | LYNX1 | Ly6/neurotoxin 1 | This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to function as a modulator of nAChR activity to prevent exces sive excitation. Alternatively spliced transcript variants have been found for this gene. Read-through transcription between this gene and the neighboring downstream gene (SLURP2) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017] | 8 | 142771197 | 142777872 | Human | 101 | symbol , old_gene_name , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 11996436 | LYNX1 | Ly6/neurotoxin 1 | ENCODES a protein that exhibits acetylcholine receptor binding (inferred); acetylcholine receptor inhibitor activity (inferred); acetylcholine receptor regulator activity (inferred); INVOLVED IN regulation of neurotransmitter receptor activity (ortholog); synaptic transmission, cholinergic (ortholog ); FOUND IN dendrite (inferred); endoplasmic reticulum (inferred); membrane (inferred) | 8 | 139483627 | 139490722 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12486461 | Lynx1 | Ly6/neurotoxin 1 | ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); acetylcholine receptor inhibitor activity (ortholog); acetylcholine receptor regulator activity (ortholog); INVOLVED IN regulation of neurotransmitter receptor activity (ortholog); synaptic transmission, cholinergic (ortholog ); FOUND IN membrane (ortholog); plasma membrane (ortholog) | NW_004936470 | 9109888 | 9115271 | Squirrel | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13932784 | LYNX1 | Ly6/neurotoxin 1 | ENCODES a protein that exhibits acetylcholine receptor binding (inferred); acetylcholine receptor inhibitor activity (inferred); acetylcholine receptor regulator activity (inferred); INVOLVED IN regulation of neurotransmitter receptor activity (ortholog); synaptic transmission, cholinergic (ortholog ); FOUND IN dendrite (inferred); endoplasmic reticulum (inferred); membrane (inferred) | | | | Pig | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18339193 | LYNX1 | Ly6/neurotoxin 1 | ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); acetylcholine receptor inhibitor activity (ortholog); acetylcholine receptor regulator activity (ortholog); INVOLVED IN regulation of neurotransmitter receptor activity (ortholog); synaptic transmission, cholinergic (ortholog ); FOUND IN membrane (ortholog) | | | | Green Monkey | 11 | symbol , ensembl_gene_symbol , ensembl_full_name | gene, protein-coding, MODEL [RefSeq] |
| 626118012 | Lynx1 | Ly6/neurotoxin 1 | ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); acetylcholine receptor inhibitor activity (ortholog); acetylcholine receptor regulator activity (ortholog); INVOLVED IN regulation of neurotransmitter receptor activity (ortholog); synaptic transmission, cholinergic (ortholog ); FOUND IN membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13438473 | LYNX1-SLURP2 | LYNX1-SLURP2 readthrough | This locus represents naturally occurring read-through transcription between the neighboring LYNX1 and SLURP2 genes. The readthrough transcript encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. [provided by RefSeq, Sep 2017] | 8 | 142764338 | 142777872 | Human | 18 | symbol , old_gene_name , COSMIC , name , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 18915666 | LOC101702588 | ly-6/neurotoxin-like protein 1 | ENCODES a protein that exhibits acetylcholine receptor binding (inferred); acetylcholine receptor inhibitor activity (inferred); acetylcholine receptor regulator activity (inferred); FOUND IN dendrite (inferred); endoplasmic reticulum (inferred); membrane (inferred) | | | | Naked Mole-Rat | 11 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8828444 | LOC102021088 | ly-6/neurotoxin-like protein 1 | | NW_004955454 | 1461378 | 1467194 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12412134 | SLURP2 | secreted LY6/PLAUR domain containing 2 | ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); acetylcholine receptor regulator activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); regulation of neurotransmitter receptor activity (ortholog); FOUND IN extracellular space (ortholog) | 13 | 36800267 | 36808315 | Dog | 6 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 13434568 | SLURP2 | secreted LY6/PLAUR domain containing 2 | This gene encodes a novel, secreted member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This gene is mainly expressed in epithelial cells, including skin and keratinocytes, and is up-regulated in psoriatic skin lesions, suggesting its involvement in the pathophysiology of psoriasis. Alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (LYNX1) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017] | 8 | 142764338 | 142769828 | Human | 24 | description | gene, protein-coding, REVIEWED [RefSeq] |