SLURP2 (secreted LY6/PLAUR domain containing 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: SLURP2 (secreted LY6/PLAUR domain containing 2) Homo sapiens
Analyze
Symbol: SLURP2
Name: secreted LY6/PLAUR domain containing 2
RGD ID: 13434568
HGNC Page HGNC
Description: Exhibits acetylcholine receptor binding activity and acetylcholine receptor regulator activity. Involved in acetylcholine receptor signaling pathway and regulation of neurotransmitter receptor activity. Localizes to extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: secreted Ly-6/uPAR domain-containing protein 2; secreted Ly-6/uPAR-related protein 2; secreted LY6/PLAUR domain-containing protein 2; secreted Ly6/uPAR related protein 2; SLURP-2
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8142,764,338 - 142,769,828 (-)EnsemblGRCh38hg38GRCh38
GRCh388142,764,338 - 142,769,828 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378143,845,756 - 143,851,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map8q24.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11181995   PMID:12573258   PMID:12975309   PMID:16421571   PMID:16575903   PMID:17643396   PMID:21873635   PMID:23376485   PMID:24877120   PMID:26033490   PMID:27098205   PMID:27485575  
PMID:29505672  


Genomics

Comparative Map Data
SLURP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8142,764,338 - 142,769,828 (-)EnsemblGRCh38hg38GRCh38
GRCh388142,764,338 - 142,769,828 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378143,845,756 - 143,851,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map8q24.3NCBI
Slurp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,614,688 - 74,618,536 (-)NCBIGRCm39mm39
GRCm39 Ensembl1574,614,613 - 74,618,542 (-)Ensembl
GRCm381574,742,839 - 74,746,687 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,742,764 - 74,746,693 (-)EnsemblGRCm38mm10GRCm38
MGSCv371574,573,269 - 74,577,117 (-)NCBIGRCm37mm9NCBIm37
MGSCv361574,573,269 - 74,577,117 (-)NCBImm8
Celera1576,247,795 - 76,251,643 (-)NCBICelera
Cytogenetic Map15D3NCBI
Slurp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27106,627,775 - 106,631,655 (-)NCBI
Rnor_6.0 Ensembl7115,977,852 - 115,981,731 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07115,977,854 - 115,981,734 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07115,883,243 - 115,887,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47112,857,541 - 112,861,421 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17112,891,770 - 112,895,648 (-)NCBI
Celera7103,028,923 - 103,032,803 (-)NCBICelera
Cytogenetic Map7q34NCBI
SLURP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18142,519,646 - 142,520,742 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v08139,476,767 - 139,483,483 (-)NCBIMhudiblu_PPA_v0panPan3
SLURP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,800,267 - 36,808,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,675,793 - 36,681,010 (-)NCBI
ROS_Cfam_1.01337,203,221 - 37,208,442 (-)NCBI
UMICH_Zoey_3.11336,921,934 - 36,927,146 (-)NCBI
UNSW_CanFamBas_1.01337,011,645 - 37,016,776 (-)NCBI
Slurp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053031,690,055 - 1,693,487 (+)NCBI
SpeTri2.0NW_0049364709,116,363 - 9,119,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 2 8 7 2 8
Medium 1515 1176 7 45 34 1903 853 140 12 348 5 45 19 1295
Low 540 816 972 172 270 95 1374 561 2959 44 741 1083 77 936 831
Below cutoff 156 664 410 161 576 124 697 644 432 53 15 135 37 236 586

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000317543   ⟹   ENSP00000319846
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8142,764,338 - 142,769,828 (-)Ensembl
RefSeq Acc Id: ENST00000521396   ⟹   ENSP00000428465
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8142,764,351 - 142,769,785 (-)Ensembl
RefSeq Acc Id: NM_001356372   ⟹   NP_001343301
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388142,764,338 - 142,769,828 (-)NCBI
Sequence:
RefSeq Acc Id: NM_177458   ⟹   NP_803253
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388142,764,338 - 142,769,828 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001343301   ⟸   NM_001356372
- Peptide Label: isoform 2 precursor
- Sequence:
RefSeq Acc Id: NP_803253   ⟸   NM_177458
- Peptide Label: isoform 1 precursor
- UniProtKB: P0DP57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000428465   ⟸   ENST00000521396
RefSeq Acc Id: ENSP00000319846   ⟸   ENST00000317543
Protein Domains
UPAR/Ly6

Promoters
RGD ID:7214301
Promoter ID:EPDNEW_H12896
Type:multiple initiation site
Name:SLURP2_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388142,769,828 - 142,769,888EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:142201468-144002730)x1 copy number loss See cases [RCV000135981] Chr8:142201468..144002730 [GRCh38]
Chr8:143282829..145076898 [GRCh37]
Chr8:143280736..145148886 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:142763122-142880038)x3 copy number gain See cases [RCV000140669] Chr8:142763122..142880038 [GRCh38]
Chr8:143844540..143961454 [GRCh37]
Chr8:143841542..143958456 [NCBI36]
Chr8:8q24.3
likely benign
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:141738068-144140607)x1 copy number loss See cases [RCV000140913] Chr8:141738068..144140607 [GRCh38]
Chr8:142764538..145195510 [GRCh37]
Chr8:142823655..145267498 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
NM_177458.3(SLURP2):c.258C>T (p.Ile86=) single nucleotide variant not provided [RCV000925073] Chr8:142764641 [GRCh38]
Chr8:143846059 [GRCh37]
Chr8:8q24.3
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25549 AgrOrtholog
COSMIC SLURP2 COSMIC
Ensembl Genes ENSG00000283992 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000319846 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428465 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000317543 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000521396 ENTREZGENE, UniProtKB/TrEMBL
GTEx ENSG00000283992 GTEx
HGNC ID HGNC:25549 ENTREZGENE
Human Proteome Map SLURP2 Human Proteome Map
InterPro LY6_UPA_recep-like UniProtKB/Swiss-Prot
KEGG Report hsa:432355 UniProtKB/Swiss-Prot
NCBI Gene SLURP2 ENTREZGENE
Pfam UPAR_LY6 UniProtKB/Swiss-Prot
PharmGKB PA166181638 PharmGKB
UniProt H0YB12_HUMAN UniProtKB/TrEMBL
  P0DP57 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3DWI7 UniProtKB/Swiss-Prot
  G3XAC2 UniProtKB/Swiss-Prot
  Q86SR0 UniProtKB/Swiss-Prot
  Q9BZG9 UniProtKB/Swiss-Prot