| 621034 | Leprot | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN negative regulation of growth hormone receptor signaling pathway (ortholog); negative regulation of protein localization to cell surface (ortholog); negative regulation of receptor signaling pathway via JAK-STAT (orth olog); FOUND IN endosome (ortholog); Golgi apparatus (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 5 | 121405170 | 121417273 | Rat | 80 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1353937 | LEPROT | leptin receptor overlapping transcript | LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010] | 1 | 65420668 | 65436007 | Human | 74 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1553364 | Leprot | leptin receptor overlapping transcript | Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface; and negative regulation of signal transduction. Predicted to be located in Gol gi apparatus. Predicted to be active in endosome. Is expressed in central nervous system; heart valve; and retina nuclear layer. Orthologous to human LEPROT (leptin receptor overlapping transcript). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 101504922 | 101516561 | Mouse | 94 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8992053 | Leprot | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN negative regulation of growth hormone receptor signaling pathway (ortholog); negative regulation of protein localization to cell surface (ortholog); negative regulation of receptor signaling pathway via JAK-STAT (orth olog); FOUND IN endosome (ortholog); Golgi apparatus (ortholog) | NW_004955423 | 25250873 | 25265437 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11945309 | LEPROT | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN positive regulation of protein targeting to mitochondrion (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); Golgi apparatus (inferred) | 1 | 64668316 | 64682016 | Bonobo | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12179533 | LEPROT | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN positive regulation of protein targeting to mitochondrion (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); Golgi apparatus (inferred) | 5 | 44859886 | 44877144 | Dog | 15 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12637280 | Leprot | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN positive regulation of protein targeting to mitochondrion (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); Golgi apparatus (inferred) | NW_004936692 | 2840461 | 2850756 | Squirrel | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14206912 | LEPROT | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN positive regulation of protein targeting to mitochondrion (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); Golgi apparatus (inferred) | | | | Pig | 12 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18549441 | LEPROT | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (inferred); INVOLVED IN positive regulation of protein targeting to mitochondrion (ortholog); FOUND IN endosome (inferred); endosome membrane (inferred); Golgi apparatus (inferred) | | | | Green Monkey | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930405 | Leprot | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN negative regulation of protein localization to cell surface (ortholog); negative regulation of receptor signaling pathway via JAK-STAT (ortholog); positive regulation of protein targeting to mitochondrion (ortholog); FOUND IN Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244978 | leprot | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625947843 | Leprot | leptin receptor overlapping transcript | ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN negative regulation of growth hormone receptor signaling pathway (ortholog); negative regulation of protein localization to cell surface (ortholog); negative regulation of receptor signaling pathway via JAK-STAT (orth olog); FOUND IN endosome (ortholog); Golgi apparatus (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256361 | leprot.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248905 | leprot.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 10865 | Lepr | leptin receptor | Enables leptin receptor activity. Involved in several processes, including glucose homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and respiratory system. Used to study metabolic dysfunction-associated steatotic liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 101574393 | 101676375 | Mouse | 1346 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1307168 | Leprotl1 | leptin receptor overlapping transcript-like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 2,4-dinitrotoluene; amphetamine; bisphenol A | 16 | 64744148 | 64756776 | Rat | 72 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1316198 | LEPROTL1 | leptin receptor overlapping transcript like 1 | Enables identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 30095408 | 30138348 | Human | 72 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1316199 | Leprotl1 | leptin receptor overlapping transcript-like 1 | Predicted to enable identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endosome . Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human LEPROTL1 (leptin receptor overlapping transcript like 1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 34602726 | 34613893 | Mouse | 87 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8892103 | Leprotl1 | leptin receptor overlapping transcript like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog) | NW_004955463 | 6580294 | 6585738 | Chinchilla | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11976530 | LEPROTL1 | leptin receptor overlapping transcript like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN late endosome to vacuole transport via multivesicular body sorting pathway (inferred); negative regulation of growth hormone receptor signaling pathway (inferred); ASSOCIATED WITH hereditary breast ovarian cancer syndr ome (ortholog); FOUND IN endosome (inferred); membrane (inferred) | 8 | 29397120 | 29409825 | Bonobo | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12154565 | LEPROTL1 | leptin receptor overlapping transcript like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN membrane (inferred) | 16 | 34176810 | 34195552 | Dog | 11 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12540489 | Leprotl1 | leptin receptor overlapping transcript like 1 | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN late endosome to vacuole transport via multivesicular body sorting pathway (inferred); negative regulation of growth hormone receptor signaling pathway (inferred); ASSOCIATED WITH hereditary breast ovarian cancer syndr ome (ortholog); FOUND IN endosome (inferred); membrane (inferred) | NW_004936573 | 83835 | 94825 | Squirrel | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14068027 | LEPROTL1 | leptin receptor overlapping transcript like 1 | ENCODES a protein that exhibits identical protein binding (inferred); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN membrane (inferred) | | | | Pig | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18551893 | LEPROTL1 | leptin receptor overlapping transcript like 1 | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN late endosome to vacuole transport via multivesicular body sorting pathway (inferred); negative regulation of growth hormone receptor signaling pathway (inferred); ASSOCIATED WITH hereditary breast ovarian cancer syndr ome (ortholog); FOUND IN endosome (inferred); membrane (inferred) | | | | Green Monkey | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285915887 | leprotl1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625870251 | Leprotl1 | leptin receptor overlapping transcript like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287531395 | leprotl1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 285916774 | leprotl1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18926046 | LOC101721466 | leptin receptor overlapping transcript-like 1 | INVOLVED IN late endosome to vacuole transport via multivesicular body sorting pathway (inferred); negative regulation of growth hormone receptor signaling pathway (inferred); FOUND IN endosome (inferred); membrane (inferred) | | | | Naked Mole-Rat | 4 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 735832 | LEPR | leptin receptor | The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regula tion of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] | 1 | 65420652 | 65641559 | Human | 674 | description | gene, protein-coding, REVIEWED [RefSeq] |
