| 1320514 | KLK5 | kallikrein related peptidase 5 | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members l ocated in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] | 19 | 50943303 | 50953038 | Human | 61 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1593461 | Klk5 | kallikrein related-peptidase 5 | ENCODES a protein that exhibits peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN antibacterial peptide biosynthetic process (ortholog); positive regulation of G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH Prostatic Neoplasms (orthol og); FOUND IN epidermal lamellar body (ortholog); extracellular space (ortholog); INTERACTS WITH N,N-diethyl-m-toluamide; permethrin; (S)-nicotine (ortholog) | 1 | 103432743 | 103442011 | Rat | 57 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1615877 | Klk5 | kallikrein related-peptidase 5 | Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including amelogenesis; extracellular matrix disassembly; and positive regulation of antibacterial peptide production. Predicted to be located in epidermal lamellar body. Predicted to be active in extracellular space and secretory granule. Is expressed in back skin. Orthologous to human KLK5 (kallikrein related peptidase 5). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 43483581 | 43500605 | Mouse | 72 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8895032 | Klk5 | kallikrein related peptidase 5 | ENCODES a protein that exhibits peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN antibacterial peptide biosynthetic process (ortholog); positive regulation of G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH Prostatic Neoplasms (orthol og); FOUND IN epidermal lamellar body (ortholog); extracellular space (ortholog) | NW_004955558 | 1512478 | 1520522 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12006797 | KLK5 | kallikrein related peptidase 5 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN amelogenesis (inferred); antibacterial peptide biosynthetic process (inferred); extracellular matrix disassembly (inferred); ASSOCIATED WITH Prosta tic Neoplasms (ortholog); FOUND IN epidermal lamellar body (inferred); extracellular space (inferred); secretory granule (inferred) | 19 | 47909823 | 47920671 | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12435122 | KLK5 | kallikrein related peptidase 5 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN antibacterial peptide biosynthetic process (ortholog); positive regulation of G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED W ITH Prostatic Neoplasms (ortholog); FOUND IN epidermal lamellar body (ortholog); extracellular space (ortholog) | 1 | 105914040 | 105922639 | Dog | 17 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12606045 | Klk5 | kallikrein related peptidase 5 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN amelogenesis (inferred); antibacterial peptide biosynthetic process (inferred); extracellular matrix disassembly (inferred); ASSOCIATED WITH Prosta tic Neoplasms (ortholog); FOUND IN epidermal lamellar body (inferred); extracellular space (inferred); secretory granule (inferred) | NW_004936889 | 609807 | 616777 | Squirrel | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625888785 | Klk5 | kallikrein related peptidase 5 | ENCODES a protein that exhibits peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN antibacterial peptide biosynthetic process (ortholog); positive regulation of G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH Prostatic Neoplasms (orthol og); FOUND IN epidermal lamellar body (ortholog); extracellular space (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18905132 | Klk5 | kallikrein related peptidase 5 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN antibacterial peptide biosynthetic process (ortholog); positive regulation of G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED W ITH Prostatic Neoplasms (ortholog); FOUND IN epidermal lamellar body (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14119880 | KLK5 | kallikrein related peptidase 5 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN antibacterial peptide biosynthetic process (inferred); positive regulation of G protein-coupled receptor signaling pathway (inferred); proteolysis (inferred); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN epidermal lamellar body (inferred); extracellular space (inferred) | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18752171 | KLK5 | kallikrein related peptidase 5 | ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN amelogenesis (inferred); antibacterial peptide biosynthetic process (inferred); extracellular matrix disassembly (inferred); ASSOCIATED WITH Prosta tic Neoplasms (ortholog); FOUND IN epidermal lamellar body (inferred); extracellular space (inferred); secretory granule (inferred) | | | | Green Monkey | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 2969 | Klk1 | kallikrein 1 | ENCODES a protein that exhibits endopeptidase activity; INVOLVED IN positive regulation of acute inflammatory response; positive regulation of apoptotic process; positive regulation of cell population proliferation; PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH Experimental Diabe tes Mellitus; hypertension; Inflammation; FOUND IN acrosomal vesicle; apical part of cell; nucleus (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; ammonium chloride | 1 | 103779152 | 103783270 | Rat | 140 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1615983 | Klk1b5 | kallikrein 1-related peptidase b5 | This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic clea vage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016] | 7 | 43865898 | 43870127 | Mouse | 42 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1598667 | Klk5l1 | kallikrein related-peptidase 5 like 1 | ENCODES a protein that exhibits serine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); INTERACTS WITH 17beta-estradiol; bisphenol A; Cuprizon | 1 | 103694483 | 103705483 | Rat | 12 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16565201 | AC011483.2 | novel transcript, antisense to KLK5 and KLK6 | | | | | Human | | name | gene, lncrna |
| 11400164 | Klk5l2 | kallikrein related-peptidase 5 like 2 | | 1 | 103788863 | 103806067 | Rat | | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 7690508 | Klk5l-ps1 | kallikrein related-peptidase 5 like, pseudogene 1 | | 1 | 103614838 | 103625620 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41248172 | Klk5l-ps2 | kallikrein related-peptidase 5 like, pseudogene 2 | | 1 | 103741919 | 103748988 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 11360787 | Klk5l-ps3 | kallikrein related-peptidase 5 like, pseudogene 3 | | 1 | 103531181 | 103536598 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1603723 | SPINK9 | serine peptidase inhibitor Kazal type 9 | The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desq uamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015] | 5 | 148321305 | 148339852 | Human | 18 | description | gene, protein-coding, REVIEWED [RefSeq] |