| 1345038 | KCNE5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016] | X | 109623700 | 109625172 | Human | 110 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1583501 | Kcne5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | ENCODES a protein that exhibits potassium channel regulator activity (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN atrial cardiac muscle cell action potential (ortholog); cardiac muscle contraction (ortholog); negative regulation of potassium ion export across plasma membrane (ortholog); ASSOCIATED WITH Brugada syndrome (ortholog); Sudden Unexpected Nocturnal Death Syndrome (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated potassium channel complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | X | 110727234 | 110727849 | Rat | 83 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1614379 | Kcne5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | Predicted to enable potassium channel regulator activity and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. P redicted to be involved in several processes, including cardiac muscle cell action potential involved in contraction; regulation of cardiac muscle cell membrane repolarization; and regulation of monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including embryo mesenchyme; ganglia; gonad; skeletal musculature; and ventricular layer. Orthologous to human KCNE5 (potassium voltage-gated channel subfamily E regulatory subunit 5). [provided by Alliance of Genome Resources, Apr 2025] | X | 141087749 | 141089194 | Mouse | 87 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8737225 | Kcne5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | ENCODES a protein that exhibits potassium channel regulator activity (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN atrial cardiac muscle cell action potential (ortholog); cardiac muscle contraction (ortholog); negative regulation of potassium ion export across plasma membrane (ortholog); ASSOCIATED WITH Brugada syndrome (ortholog); Sudden Unexpected Nocturnal Death Syndrome (ortholog); FOUND IN plasma membrane (ortholog); voltage-gated potassium channel complex (ortholog) | NW_004955490 | 6242197 | 6243627 | Chinchilla | 21 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11826353 | KCNE5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (inferred); potassium channel regulator activity (inferred); transmembrane transporter binding (inferred); INVOLVED IN atrial cardiac muscle cell action potential (inferred); cardiac muscle contraction (inferred); membrane repolarization during action potential (inferred); ASSOCIATED WITH Brugada syndrome (ortholog); Sudden Unexpected Nocturnal Death Syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); voltage-gated potassium channel complex (inferred) | X | 98731109 | 98732575 | Bonobo | 37 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12259249 | KCNE5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | ENCODES a protein that exhibits potassium channel regulator activity (inferred); transmembrane transporter binding (inferred); voltage-gated potassium channel activity (inferred); INVOLVED IN atrial cardiac muscle cell action potential (inferred); cardiac muscle contraction (inferred); membrane repo larization during ventricular cardiac muscle cell action potential (inferred); ASSOCIATED WITH Brugada syndrome (ortholog); Sudden Unexpected Nocturnal Death Syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); voltage-gated potassium channel complex (inferred) | X | 82844188 | 82845641 | Dog | 37 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12563302 | Kcne5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (inferred); potassium channel regulator activity (inferred); transmembrane transporter binding (inferred); INVOLVED IN atrial cardiac muscle cell action potential (inferred); cardiac muscle contraction (inferred); membrane repolarization during action potential (inferred); ASSOCIATED WITH Brugada syndrome (ortholog); Sudden Unexpected Nocturnal Death Syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); voltage-gated potassium channel complex (inferred) | NW_004936499 | 5557076 | 5558467 | Squirrel | 36 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18900412 | Kcne5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (inferred); potassium channel regulator activity (inferred); transmembrane transporter binding (inferred); INVOLVED IN atrial cardiac muscle cell action potential (ortholog); cardiac muscle contraction (ortholog); negative regulation of potassium ion export across plasma membrane (ortholog); ASSOCIATED WITH Brugada syndrome (ortholog); Sudden Unexpected Nocturnal Death Syndrome (ortholog); FOUND IN plasma membrane (ortholog) | | | | Naked Mole-Rat | 30 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14115836 | KCNE5 | potassium voltage-gated channel subfamily E regulatory subunit 5 | ENCODES a protein that exhibits potassium channel regulator activity (inferred); transmembrane transporter binding (inferred); voltage-gated potassium channel activity (inferred); INVOLVED IN atrial cardiac muscle cell action potential (inferred); cardiac muscle contraction (inferred); membrane repo larization during ventricular cardiac muscle cell action potential (inferred); ASSOCIATED WITH Brugada syndrome (ortholog); Sudden Unexpected Nocturnal Death Syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); voltage-gated potassium channel complex (inferred) | | | | Pig | 37 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |