| 621539 | Ireb2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits 4 iron, 4 sulfur cluster binding; iron-responsive element binding; regulatory region RNA binding; INVOLVED IN cellular response to epidermal growth factor stimulus; cellular response to hypoxia; cellular response to iron(III) ion; PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH anemia; Brain Hypoxia; Brain Hypoxia-Ischemia; FOUND IN axon; neuronal cell body; cytoplasm (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 8 | 64124152 | 64207702 | Rat | 247 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733858 | IREB2 | iron responsive element binding protein 2 | The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] | 15 | 78437431 | 78501453 | Human | 281 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736754 | Ireb2 | iron responsive element binding protein 2 | Enables iron-responsive element binding activity. Involved in osteoclast differentiation. Acts upstream of or within several processes, including erythrocyte homeostasis; multicellular organismal-level iron ion homeostasis; and protoporphyrinogen IX biosynthetic process. Located in cytosol. Is expre ssed in several structures, including genitourinary system; hemolymphoid system gland; liver; nervous system; and yolk sac. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 54769942 | 54819812 | Mouse | 345 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8968803 | Ireb2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits 4 iron, 4 sulfur cluster binding (ortholog); iron-responsive element binding (ortholog); mRNA regulatory element binding translation repressor activity (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypox ia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Brain Hypoxia (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955450 | 852554 | 898908 | Chinchilla | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11881557 | IREB2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits regulatory region RNA binding (ortholog); RNA binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypoxia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Brain Hypoxia (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog) | 15 | 57367314 | 57430322 | Bonobo | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12132221 | IREB2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits mRNA regulatory element binding translation repressor activity (ortholog); regulatory region RNA binding (ortholog); RNA binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypoxia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Brain Hypoxia (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog) | 13 | 38398445 | 38441128 | Dog | 71 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12500331 | Ireb2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits mRNA regulatory element binding translation repressor activity (ortholog); regulatory region RNA binding (ortholog); RNA binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypoxia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Brain Hypoxia (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog) | NW_004936471 | 36547552 | 36601327 | Squirrel | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14001265 | IREB2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits iron-responsive element binding (ortholog); mRNA regulatory element binding translation repressor activity (ortholog); regulatory region RNA binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypoxia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Brain Hypoxia (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog) | | | | Pig | 75 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18900209 | Ireb2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits mRNA regulatory element binding translation repressor activity (ortholog); regulatory region RNA binding (ortholog); RNA binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypoxia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Brain Hypoxia (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); neuronal cell body (ortholog) | | | | Naked Mole-Rat | 65 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155231053 | ireb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18652005 | IREB2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits regulatory region RNA binding (ortholog); RNA binding (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypoxia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Brain Hypoxia (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626131402 | Ireb2 | iron responsive element binding protein 2 | ENCODES a protein that exhibits 4 iron, 4 sulfur cluster binding (ortholog); iron-responsive element binding (ortholog); mRNA regulatory element binding translation repressor activity (ortholog); INVOLVED IN cellular response to epidermal growth factor stimulus (ortholog); cellular response to hypox ia (ortholog); cellular response to iron(III) ion (ortholog); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anemia (ortholog); Brain Hypoxia (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236636 | ireb2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16562228 | AC027228.1 | novel transcript, antisense to IREB2 | | | | | Human | | name | gene, lncrna |
| 16561036 | AC018630.1 | iron-responsive element binding protein 2 (IREB2) | | | | | Human | | name | gene, processed_pseudogene |