| 620063 | Ilk | integrin-linked kinase | ENCODES a protein that exhibits integrin binding; protein domain specific binding; protein kinase activity; INVOLVED IN integrin-mediated signaling pathway; negative regulation of apoptotic process; negative regulation of cardiac muscle cell apoptotic process; PARTICIPATES IN integrin mediated signa ling pathway; altered integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH abnormal dendrite morphology; liver fibrosis; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon; cell-cell junction; costamere; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 1 | 169500716 | 169506972 | Rat | 299 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732855 | ILK | integrin linked kinase | This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] | 11 | 6603774 | 6610870 | Human | 287 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732856 | Ilk | integrin linked kinase | Predicted to enable several functions, including ATP binding activity; SH3 domain binding activity; and magnesium ion binding activity. Involved in several processes, including caveola assembly; integrin-mediated signaling pathway; and positive regulation of BMP signaling pathway. Acts upstream of o r within several processes, including branching involved in ureteric bud morphogenesis; nervous system development; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in focal adhesion and lamellipodium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and retina. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 105385797 | 105392132 | Mouse | 457 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8874124 | Ilk | integrin linked kinase | ENCODES a protein that exhibits ATP binding (ortholog); integrin binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN actin filament bundle assembly (ortholog); actin filament network formation (ortholog); branching involved in ureteric bud morphogenesis (ortholog); PARTICIPATES IN alte red integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); centrosome (ortholog) | NW_004955414 | 22316243 | 22322979 | Chinchilla | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12011712 | ILK | integrin linked kinase | ENCODES a protein that exhibits integrin binding (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell morphogenesis (ortholog); cell projection organization (ortholog); PARTICIPATES I N altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); costamere (ortholog) | 11 | 6735735 | 6742922 | Bonobo | 155 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12056511 | ILK | integrin linked kinase | ENCODES a protein that exhibits integrin binding (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell morphogenesis (ortholog); cell projection organization (ortholog); PARTICIPATES I N altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); costamere (ortholog) | 21 | 29911326 | 29917972 | Dog | 157 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12614113 | Ilk | integrin linked kinase | ENCODES a protein that exhibits integrin binding (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell morphogenesis (ortholog); cell projection organization (ortholog); PARTICIPATES I N altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); costamere (ortholog) | NW_004936842 | 661961 | 667993 | Squirrel | 155 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14129963 | ILK | integrin linked kinase | ENCODES a protein that exhibits integrin binding (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell morphogenesis (ortholog); cell projection organization (ortholog); PARTICIPATES I N altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); costamere (ortholog) | | | | Pig | 159 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14386241 | Ilk | | | | | | Fly | | symbol | gene, null |
| 18768722 | ILK | integrin linked kinase | ENCODES a protein that exhibits integrin binding (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell morphogenesis (ortholog); cell projection organization (ortholog); PARTICIPATES I N altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); costamere (ortholog) | | | | Green Monkey | 154 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18931228 | Ilk | integrin linked kinase | ENCODES a protein that exhibits integrin binding (ortholog); protein domain specific binding (ortholog); protein kinase activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell morphogenesis (ortholog); cell projection organization (ortholog); PARTICIPATES I N altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); costamere (ortholog) | | | | Naked Mole-Rat | 157 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252027 | ilk | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625959339 | Ilk | integrin linked kinase | ENCODES a protein that exhibits ATP binding (ortholog); integrin binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN actin filament bundle assembly (ortholog); actin filament network formation (ortholog); branching involved in ureteric bud morphogenesis (ortholog); PARTICIPATES IN alte red integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Cocaine-Related Disorders (ortholog); Colonic Polyps (ortholog); FOUND IN axon (ortholog); cell-cell junction (ortholog); centrosome (ortholog) | | | | Black Rat | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626179673 | ilk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626187877 | ilk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245782 | ilk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 620128 | Ilkap | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity; INVOLVED IN protein dephosphorylation; regulation of nuclear cell cycle DNA replication; PARTICIPATES IN integrin mediated signaling pathway; FOUND IN cytoplasm (inferred); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8 -tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione | 9 | 99413981 | 99436262 | Rat | 60 | symbol , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731849 | ILKAP | ILK associated serine/threonine phosphatase | The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the ki nase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008] | 2 | 238170402 | 238203695 | Human | 62 | symbol , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 9036180 | Ilkap | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of nuclear cell cycle DNA replication (ortholog); PARTICIPATES IN integrin mediated signaling pathway | NW_004955542 | 2391432 | 2407559 | Chinchilla | 6 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11676344 | ILKAP | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of nuclear cell cycle DNA replication (ortholog); PARTICIPATES IN integrin mediated signaling pathway; FOUND IN cytoplasm (inferred) | 2B | 125403220 | 125436614 | Bonobo | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12227664 | ILKAP | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of nuclear cell cycle DNA replication (ortholog); PARTICIPATES IN integrin mediated signaling pathway; FOUND IN cytoplasm (inferred) | 25 | 48666850 | 48689405 | Dog | 15 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12675678 | Ilkap | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of nuclear cell cycle DNA replication (ortholog); PARTICIPATES IN integrin mediated signaling pathway | NW_004936525 | 303436 | 322677 | Squirrel | 7 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 14251104 | ILKAP | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of nuclear cell cycle DNA replication (ortholog); PARTICIPATES IN integrin mediated signaling pathway; FOUND IN cytoplasm (inferred) | | | | Pig | 17 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18648696 | ILKAP | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of nuclear cell cycle DNA replication (ortholog); PARTICIPATES IN integrin mediated signaling pathway; FOUND IN cytoplasm (inferred) | | | | Green Monkey | 13 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18919909 | Ilkap | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of nuclear cell cycle DNA replication (ortholog); PARTICIPATES IN integrin mediated signaling pathway; FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 15 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 625993182 | Ilkap | ILK associated serine/threonine phosphatase | ENCODES a protein that exhibits protein serine/threonine phosphatase activity (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of nuclear cell cycle DNA replication (ortholog); PARTICIPATES IN integrin mediated signaling pathway | | | | Black Rat | 6 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 1313204 | LIMS2 | LIM zinc finger domain containing 2 | This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain fo rming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] | 2 | 127638426 | 127681786 | Human | 159 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1552991 | Ilkap | integrin-linked kinase-associated serine/threonine phosphatase 2C | Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in regulation of nuclear cell cycle DNA replication and signal transduction. Predicted to be located in cytoplasm. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 91301568 | 91326566 | Mouse | 66 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 155237645 | ilkap | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14384558 | ilkp-1 | | | | | | Roundworm | | symbol | gene, null |
| 155252623 | ilkap.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 731888 | Parva | parvin, alpha | Enables actin binding activity. Involved in several processes, including circulatory system development; smooth muscle cell chemotaxis; and substrate adhesion-dependent cell spreading. Acts upstream of or within cell adhesion. Located in several cellular components, including focal adhesion; lamelli podium; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PARVA (parvin alpha). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 112027102 | 112190899 | Mouse | 183 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1352322 | PARVA | parvin alpha | This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, mot ility and survival. [provided by RefSeq, Dec 2010] | 11 | 12376436 | 12535356 | Human | 156 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |