| 69235 | Htra1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); molecular function activator activity (ortholog); serine-type peptidase activity (ortholog); INVOLVED IN negative regulation of defense response to virus; positive regulation of epithelial cell proliferation; chorionic trophoblast cell differentiation (ortholog); ASSOCIATED WITH age related macular degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix; plasma membrane (ortholog); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 1 | 194928069 | 194977619 | Rat | 268 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732659 | HTRA1 | HtrA serine peptidase 1 | This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008] | 10 | 122461553 | 122514907 | Human | 454 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1621557 | Htra1 | HtrA serine peptidase 1 | Enables serine-type peptidase activity. Involved in proteolysis. Acts upstream of or within chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Located in collagen-containing extracellu lar matrix. Is expressed in several structures, including brain; genitourinary system; heart; limb; and sensory organ. Human ortholog(s) of this gene implicated in CADASIL (multiple); gastrointestinal system cancer (multiple); hypertension; lung adenocarcinoma; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 130537933 | 130587388 | Mouse | 271 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8972276 | Htra1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); molecular function activator activity (ortholog); serine-type peptidase activity (ortholog); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regu lation of defense response to virus (ortholog); ASSOCIATED WITH age related macular degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix (ortholog); plasma membrane (ortholog) | NW_004955477 | 761127 | 808396 | Chinchilla | 66 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11675975 | HTRA1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regulation of defense response to virus (ortholog); ASSOCIATED WITH age related macul ar degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix (ortholog) | 10 | 119030409 | 119083682 | Bonobo | 79 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12054297 | HTRA1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regulation of defense response to virus (ortholog); ASSOCIATED WITH age related macul ar degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix (ortholog) | 28 | 32133779 | 32157835 | Dog | 81 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12572421 | Htra1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regulation of defense response to virus (ortholog); ASSOCIATED WITH age related macul ar degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix (ortholog) | NW_004936486 | 11271130 | 11317271 | Squirrel | 80 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625869971 | Htra1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); molecular function activator activity (ortholog); serine-type peptidase activity (ortholog); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regu lation of defense response to virus (ortholog); ASSOCIATED WITH age related macular degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix (ortholog); plasma membrane (ortholog) | | | | Black Rat | 66 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18776224 | HTRA1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regulation of defense response to virus (ortholog); ASSOCIATED WITH age related macul ar degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix (ortholog) | | | | Green Monkey | 80 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18914197 | Htra1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits identical protein binding (ortholog); molecular function activator activity (ortholog); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regulation of defense response to virus (orthol og); ASSOCIATED WITH age related macular degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 78 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155253748 | htra1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13890243 | HTRA1 | HtrA serine peptidase 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); negative regulation of BMP signaling pathway (ortholog); negative regulation of defense response to virus (ortholog); ASSOCIATED WITH age related macul ar degeneration (ortholog); age related macular degeneration 7 (ortholog); CADASIL (ortholog); FOUND IN extracellular matrix (ortholog); INTERACTS WITH deoxynivalenol; ethanol | | | | Pig | 83 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155246416 | htra1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258552 | htra1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38661444 | HTRA1-AS1 | HTRA1 and ARMS2 antisense RNA 1 | | 10 | 122448059 | 122461405 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |