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Gene: HTRA1 (HtrA serine peptidase 1) Homo sapiens
Symbol: HTRA1
Name: HtrA serine peptidase 1
Description: Exhibits identical protein binding activity. Predicted to be involved in proteolysis. Localizes to the plasma membrane. Implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARMD7; CADASIL2; CARASIL; high-temperature requirement A serine peptidase 1; HtrA; IGFBP5-protease; L56; ORF480; protease, serine, 11; protease, serine, 11 (IGF binding); PRSS11; serine protease HTRA1
Mus musculus (house mouse) : Htra1 (HtrA serine peptidase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Htra1 (HtrA serine peptidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htra1 (HtrA serine peptidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HTRA1 (HtrA serine peptidase 1)
Canis lupus familiaris (dog) : HTRA1 (HtrA serine peptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htra1 (HtrA serine peptidase 1)
Sus scrofa (pig) : HTRA1 (HtrA serine peptidase 1)
Chlorocebus sabaeus (African green monkey) : HTRA1 (HtrA serine peptidase 1)
Heterocephalus glaber (naked mole-rat) : Htra1 (HtrA serine peptidase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10122,458,551 - 122,514,907 (+)Ensembl
GRCh3810122,461,553 - 122,514,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710124,221,041 - 124,274,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610124,211,047 - 124,264,413 (+)NCBINCBI36hg18NCBI36
Build 3410124,211,110 - 124,264,413NCBI
Celera10117,953,296 - 118,006,683 (+)NCBI
Cytogenetic Map10q26.13NCBI
HuRef10117,851,770 - 117,905,378 (+)NCBIHuRef
CHM1_110124,505,637 - 124,559,026 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HTRA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732659
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.