| 2850 | Htr4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity; identical protein binding (ortholog); serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; gamma-aminobutyric acid signaling pathway; adenylate cyc lase-activating serotonin receptor signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3H-1,2-dithiole-3-thione | 18 | 58036277 | 58221327 | Rat | 159 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10750 | Htr4 | 5 hydroxytryptamine (serotonin) receptor 4 | Enables G protein-coupled serotonin receptor activity. Involved in several processes, including maintenance of gastrointestinal epithelium; mucus secretion; and regulation of postsynapse assembly. Is active in glutamatergic synapse; plasma membrane; and postsynapse. Is expressed in several structure s, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 62456618 | 62636098 | Mouse | 162 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 736061 | HTR4 | 5-hydroxytryptamine receptor 4 | This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system t o modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010] | 5 | 148451032 | 148654527 | Human | 146 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8819312 | Htr4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); identical protein binding (ortholog); serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-activating serot onin receptor signaling pathway (ortholog); G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); membrane (ortholog) | NW_004955415 | 5745056 | 5802409 | Chinchilla | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11820586 | HTR4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN cytoplasm (inferred); endosome membrane (inferred); glutamatergic synapse (inferred) | 5 | 143918925 | 144208779 | Bonobo | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12412643 | HTR4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN cytoplasm (inferred); endosome membrane (inferred); glutamatergic synapse (inferred) | 4 | 60224534 | 60359244 | Dog | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12487679 | Htr4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN cytoplasm (inferred); endosome membrane (inferred); glutamatergic synapse (inferred) | NW_004936504 | 6146974 | 6306000 | Squirrel | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13896438 | HTR4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-activating serotonin receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN plasma membrane (ortholog) | | | | Pig | 57 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155237738 | htr4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18768954 | HTR4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN cytoplasm (inferred); endosome membrane (inferred); glutamatergic synapse (inferred) | | | | Green Monkey | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625941636 | Htr4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); identical protein binding (ortholog); serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-activating serot onin receptor signaling pathway (ortholog); G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); membrane (ortholog) | | | | Black Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915071 | Htr4 | 5-hydroxytryptamine receptor 4 | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); identical protein binding (ortholog); serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-activating serot onin receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250452 | htr4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861826 | htr4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864999 | htr4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861422 | htr4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468681 | htr4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468961 | htr4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857576 | htr4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1306242 | Htra4 | HtrA serine peptidase 4 | ENCODES a protein that exhibits endopeptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN proteolysis (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibe nzodioxine; 2,6-dinitrotoluene | 16 | 73704255 | 73717722 | Rat | 79 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12151727 | HTRA4 | HtrA serine peptidase 4 | ENCODES a protein that exhibits endopeptidase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); FOUND IN extracellular region (inferred) | 16 | 26558426 | 26568570 | Dog | 19 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |