HTR4 (5-hydroxytryptamine receptor 4) - Rat Genome Database

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Gene: HTR4 (5-hydroxytryptamine receptor 4) Chlorocebus sabaeus
Analyze
Symbol: HTR4
Name: 5-hydroxytryptamine receptor 4
RGD ID: 18768954
Description: ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); PARTICIPATES IN serotonin signaling pathway via receptors engaging G alphas protein family; ASSOCIATED WITH Anorexia (ortholog); anorexia nervosa (ortholog); atrial fibrillation (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12351,087,430 - 51,279,915 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2351,087,285 - 51,182,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603426,474,972 - 26,668,312 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HTR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12351,087,430 - 51,279,915 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2351,087,285 - 51,182,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603426,474,972 - 26,668,312 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HTR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385148,451,032 - 148,654,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5148,446,042 - 148,677,235 (-)EnsemblGRCh38hg38GRCh38
GRCh375147,830,595 - 148,034,090 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,810,788 - 148,013,934 (-)NCBINCBI36Build 36hg18NCBI36
Build 345147,841,291 - 148,013,909NCBI
Celera5143,909,957 - 144,112,979 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5142,977,652 - 143,180,200 (-)NCBIHuRef
CHM1_15147,263,294 - 147,466,440 (-)NCBICHM1_1
T2T-CHM13v2.05148,985,559 - 149,189,026 (-)NCBIT2T-CHM13v2.0
Htr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391862,456,618 - 62,636,098 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1862,457,275 - 62,629,648 (+)EnsemblGRCm39 Ensembl
GRCm381862,323,546 - 62,503,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1862,324,204 - 62,496,577 (+)EnsemblGRCm38mm10GRCm38
MGSCv371862,483,858 - 62,627,456 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361862,449,573 - 62,593,171 (+)NCBIMGSCv36mm8
Celera1863,595,586 - 63,739,634 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.1NCBI
Htr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81858,036,277 - 58,221,327 (+)NCBIGRCr8
mRatBN7.21855,765,981 - 55,949,921 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,766,725 - 55,949,321 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,859,595 - 58,004,005 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01858,573,357 - 58,718,297 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01856,389,844 - 56,534,835 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01857,637,013 - 57,820,317 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1857,654,290 - 57,819,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,863,669 - 57,046,345 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41858,417,163 - 58,468,888 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11858,489,392 - 58,542,436 (+)NCBI
Celera1853,929,187 - 54,054,080 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Htr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554155,685,309 - 5,802,409 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554155,745,056 - 5,802,409 (+)NCBIChiLan1.0ChiLan1.0
HTR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,683,697 - 144,013,085 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,823,246 - 142,152,592 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,918,925 - 144,208,779 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,889,969 - 150,097,024 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5149,889,969 - 150,108,357 (-)Ensemblpanpan1.1panPan2
HTR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1460,224,534 - 60,359,244 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl460,185,056 - 60,353,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,949,833 - 60,122,933 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0460,674,206 - 60,843,707 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl460,674,419 - 60,840,580 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1460,454,461 - 60,627,575 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0460,581,160 - 60,754,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0461,099,415 - 61,272,556 (+)NCBIUU_Cfam_GSD_1.0
Htr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213144,536,506 - 144,732,575 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365046,146,974 - 6,265,631 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365046,146,974 - 6,306,000 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2149,731,034 - 149,912,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12149,768,295 - 149,813,801 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22156,451,710 - 156,485,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Htr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247747,887,577 - 8,027,500 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247747,851,451 - 8,027,524 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 19
Low 11 13 23
Below cutoff 14 4 7

Sequence


RefSeq Acc Id: ENSCSAT00000009969   ⟹   ENSCSAP00000008072
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2351,087,285 - 51,182,200 (-)Ensembl
RefSeq Acc Id: XM_008014918   ⟹   XP_008013109
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12351,116,699 - 51,279,906 (-)NCBI
Vero_WHO_p1.0NW_02366603426,474,973 - 26,638,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008014919   ⟹   XP_008013110
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12351,119,315 - 51,279,905 (-)NCBI
Vero_WHO_p1.0NW_02366603426,474,972 - 26,637,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038006201   ⟹   XP_037862129
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603426,475,566 - 26,638,430 (+)NCBI
RefSeq Acc Id: XM_038006202   ⟹   XP_037862130
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603426,475,566 - 26,668,312 (+)NCBI
RefSeq Acc Id: XM_038006203   ⟹   XP_037862131
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603426,475,566 - 26,637,454 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008013109 (Get FASTA)   NCBI Sequence Viewer  
  XP_008013110 (Get FASTA)   NCBI Sequence Viewer  
  XP_037862129 (Get FASTA)   NCBI Sequence Viewer  
  XP_037862130 (Get FASTA)   NCBI Sequence Viewer  
  XP_037862131 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008072.1
RefSeq Acc Id: XP_008013109   ⟸   XM_008014918
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008013110   ⟸   XM_008014919
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RHI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000008072   ⟸   ENSCSAT00000009969
RefSeq Acc Id: XP_037862130   ⟸   XM_038006202
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RHI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037862129   ⟸   XM_038006201
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037862131   ⟸   XM_038006203
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011878 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009969.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 5HT4_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene HTR4 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR 4 UniProtKB/TrEMBL
  ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS 5HT4RECEPTR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0D9RHI3 ENTREZGENE, UniProtKB/TrEMBL