| 62040 | Hpx | hemopexin | ENCODES a protein that exhibits heme transmembrane transporter activity (inferred); metal ion binding (inferred); INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 1 | 169344647 | 169352155 | Rat | 195 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62332 | Hpx | hemopexin | Predicted to enable heme binding activity. Acts upstream of or within several processes, including positive regulation of immune effector process; positive regulation of type II interferon-mediated signaling pathway; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to b e active in extracellular space. Is expressed in brain; embryo; liver; liver left lobe; and liver right lobe. Orthologous to human HPX (hemopexin). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 105240818 | 105249323 | Mouse | 208 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737150 | HPX | hemopexin | This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009] | 11 | 6431049 | 6440987 | Human | 206 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8854849 | Hpx | hemopexin | INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver In jury (ortholog); FOUND IN extracellular space (ortholog) | NW_004955414 | 22158654 | 22169133 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11870336 | HPX | hemopexin | ENCODES a protein that exhibits heme transmembrane transporter activity (inferred); metal ion binding (inferred); INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | 11 | 6558279 | 6572946 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12375915 | HPX | hemopexin | ENCODES a protein that exhibits amyloid-beta binding (inferred); heme transmembrane transporter activity (inferred); metal ion binding (inferred); INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response mediated by circul ating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN extracellular space (ortholog) | 21 | 29749913 | 29759176 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12495449 | Hpx | hemopexin | ENCODES a protein that exhibits heme transmembrane transporter activity (inferred); metal ion binding (inferred); INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | NW_004936842 | 485515 | 495684 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935230 | Hpx | hemopexin | ENCODES a protein that exhibits heme transmembrane transporter activity (inferred); metal ion binding (inferred); INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626163564 | Hpx | hemopexin | INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver In jury (ortholog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18472390 | HPX | hemopexin | ENCODES a protein that exhibits heme transmembrane transporter activity (inferred); metal ion binding (inferred); INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response mediated by circulating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13988747 | HPX | hemopexin | ENCODES a protein that exhibits heme transmembrane transporter activity (inferred); hyalurononglucosaminidase activity (inferred); hydrolase activity (inferred); INVOLVED IN heme metabolic process (ortholog); hemoglobin metabolic process (ortholog); positive regulation of humoral immune response med iated by circulating immunoglobulin (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); autoimmune disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH ammonia | | | | Pig | 29 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155236498 | hpx | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14372383 | hpx-2 | | | | | | Roundworm | | symbol | gene, null |
| 155245237 | hpx.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 11406 | Trf | transferrin | Predicted to enable iron chaperone activity; iron ion binding activity; and transferrin receptor binding activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of bone resorption; and positive regulation of metabolic process. Acts upstream of or within iron ion transport and response to bacterium. Located in clathrin-coated pit and cytoplasmic vesicle. Is expressed in several structures, including blood; brain; liver; placenta; and white fat. Used to study atransferrinemia. Human ortholog(s) of this gene implicated in anemia (multiple); atransferrinemia; gastrointestinal system disease; glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to human TF (transferrin). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 103086075 | 103107485 | Mouse | 529 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606568 | LBX1 | ladybird homeobox 1 | This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by Re fSeq, Jul 2008] | 10 | 101226994 | 101229463 | Human | 126 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1603306 | NKX1-1 | NK1 homeobox 1 | This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coord inated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017] | 4 | 1402932 | 1406442 | Human | 20 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1602108 | MSX2P1 | msh homeobox 2 pseudogene 1 | INTERACTS WITH aflatoxin B1; all-trans-retinoic acid; benzo[a]pyrene | 17 | 58156959 | 58159120 | Human | 11 | old_gene_symbol | gene, pseudo, PROVISIONAL [RefSeq] |
| 732278 | ECH1 | enoyl-CoA hydratase 1 | This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxi somal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008] | 19 | 38815422 | 38831794 | Human | 273 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352191 | VENTXP7 | VENT homeobox pseudogene 7 | Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the Vent homeobox gene family. [provided by RefSeq, J ul 2008] | 3 | 21405726 | 21406708 | Human | 5 | old_gene_symbol | gene, pseudo, PROVISIONAL [RefSeq] |
| 1354153 | VENTX | VENT homeobox | This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromos ome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008] | 10 | 133237855 | 133241928 | Human | 64 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
